Recombinant Human E2F1 Protein, GST-tagged
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| Cat.No. : | E2F1-3002H |
| Product Overview : | Human E2F1 full-length ORF (AAH50369.1, 1 a.a. - 437 a.a.) recombinant protein with GST-tag at N-terminal. |
| Description : | The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008] |
| Source : | Wheat Germ |
| Species : | Human |
| Tag : | GST |
| Molecular Mass : | 74.47 kDa |
| AA Sequence : | MALAGAPAGG PCAPALEALL GAGALRLLDS SQIVIISAAQ DASAPPAPTG PAAPAAGPCD PDLLLFATPQ APRPTPSAPR PALGRPPVKR RLDLETDHQY LAESSGPARG RGRHPGKGVK SPGEKSRYET SLNLTTKRFL ELLSHSADGV VDLNWAAEVL KVQKRRIYDI TNVLEGIQLI AKKSKNHIQW LGSHTTVGVG GRLEGLTQDL RQLQESEQQL DHLMNICTTQ LRLLSEDTDS QRLAYVTCQD LRSIADPAEQ MVMVIKAPPE TQLQAVDSSE NFQISLKSKQ GPIDVFLCPE ETVGGISPGK TPSQEVTSEE ENRATDSATI VSPPPSSPPS SLTTDPSQSL LSLEQEPLLS RMGSLRAPVD EDRLSPLVAA DSLLEHVRED FSGLLPEEFI SLSPPHEALD YHFGLEEGEG IRDLFDCDFG DLTPLDF |
| Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
| Notes : | Best use within three months from the date of receipt of this protein. |
| Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
| Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
| Gene Name : | E2F1 E2F transcription factor 1 [ Homo sapiens ] |
| Official Symbol : | E2F1 |
| Synonyms : | E2F1; E2F transcription factor 1; RBBP3; transcription factor E2F1; RBP3; PBR3; RBAP-1; RBBP-3; PRB-binding protein E2F-1; retinoblastoma-binding protein 3; retinoblastoma-associated protein 1; E2F-1; RBAP1; |
| Gene ID : | 1869 |
| mRNA Refseq : | NM_005225 |
| Protein Refseq : | NP_005216 |
| MIM : | 189971 |
| UniProt ID : | Q01094 |
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◆ Lysates
| E2F1-6743HCL | Recombinant Human E2F1 293 Cell Lysate | +Inquiry |
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E2F1E2F4E2F8E4F1E2F3E2F6E(Y)1E2F2E2F5E6E7E2F7E. coliE130306D19RikE030002O03RikE030019B06RikE130003G02RikE130012A19RikE130303B06RikE130308A19RikE130309D14RikE130309F12RikE130311K13RikE230008N13RikE230019M04RikE230025N22RikE130304F04RikE030032D13RikE030010A14RikE130203B14RikE330009J07RikE330014E10RikE330017A01RikE330034G19RikE430025E21Rik
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