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Recombinant Human EIF4A3 Protein, GST-tagged

Cat.No. : EIF4A3-2494H
Product Overview : Human DDX48 full-length ORF ( NP_055555.1, 1 a.a. - 411 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family. [provided by RefSeq, Jul 2008]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 73.3 kDa
AA Sequence : MATTATMATSGSARKRLLKEEDMTK VEFETSEEVDVTPTFDTMGLREDLL RGIYAYGFEKPSAIQQRAIKQIIKG RDVIAQSQSGTGKTATFSISVLQCL DIQVRETQALILAPTRELAVQIQKG LLALGDYMNVQCHACIGGTNVGEDI RKLDYGQHVVAGTPGRVFDMIRRRS LRTRAIKMLVLDEADEMLNKGFKEQ IYDVYRYLPPATQVVLISATLPHEI LEMTNKFMTDPIRILVKRDELTLEG IKQFFVAVEREEWKFDTLCDLYDTL TITQAVIFCNTKRKVDWLTEKMREA NFTVSSMHGDMPQKERESIMKEFRS GASRVLISTDVWARGLDVPQVSLII NYDLPNNRELYIHRIGRSGRYGRKG VAINFVKNDDIRILRDIEQYYSTQI DEMPMNVADLI
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : EIF4A3 eukaryotic translation initiation factor 4A3 [ Homo sapiens ]
Official Symbol : EIF4A3
Synonyms : EIF4A3; eukaryotic translation initiation factor 4A3; DDX48, DEAD (Asp Glu Ala Asp) box polypeptide 48 , eukaryotic translation initiation factor 4A, isoform 3; eukaryotic initiation factor 4A-III; EIF4AIII; KIAA0111; NMP 265; hNMP 265; eIF4A-III; eIF-4A-III; DEAD box protein 48; nuclear matrix protein 265; ATP-dependent RNA helicase DDX48; ATP-dependent RNA helicase eIF4A-3; DEAD (Asp-Glu-Ala-Asp) box polypeptide 48; eukaryotic initiation factor 4A-like NUK-34; eukaryotic translation initiation factor 4A, isoform 3; DDX48; NUK34; NMP265; eIF4AIII; MGC10862; DKFZp686O16189;
Gene ID : 9775
mRNA Refseq : NM_014740
Protein Refseq : NP_055555
MIM : 608546
UniProt ID : P38919

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Are there specific RNA targets or motifs recognized by EIF4A3, and what is their functional significance? 11/16/2022

Specific RNA targets or motifs recognized by EIF4A3 include splice sites and exon junctions, with functional significance in maintaining mRNA integrity.

In which cellular compartments is EIF4A3 predominantly localized? 03/09/2022

EIF4A3 is predominantly localized in the nucleus and cytoplasm of cells, contributing to its involvement in RNA-related processes.

How does EIF4A3 contribute to the regulation of RNA metabolism, including splicing and translation? 10/05/2020

EIF4A3 contributes to the regulation of RNA metabolism by participating in splicing, translation initiation, and mRNA surveillance.

Are there therapeutic implications or potential targets related to EIF4A3 in diseases involving RNA metabolism? 04/29/2019

There are potential therapeutic implications related to EIF4A3 in diseases involving RNA metabolism, making it a target for drug development.

How does EIF4A3 influence the balance between mRNA quality control and translation efficiency? 03/15/2018

EIF4A3 influences the balance between mRNA quality control, including nonsense-mediated decay, and translation efficiency.

What is the primary function of eukaryotic translation initiation factor 4A3 (EIF4A3) in cellular processes? 02/22/2018

Eukaryotic translation initiation factor 4A3 (EIF4A3) primarily functions in cellular processes, playing a role in RNA metabolism, including splicing and translation.

What diseases or conditions are associated with dysregulation or abnormal expression of EIF4A3? 09/10/2017

Dysregulation or abnormal expression of EIF4A3 is associated with conditions such as cancer and neurodegenerative disorders.

Customer Reviews (3)

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Reviews
04/30/2022

    The product's user-friendly features facilitated seamless collaboration among team members with different expertise levels.

    03/10/2019

      The product's established reputation in the scientific community provided assurance of its reliability.

      07/25/2018

        It's batch-to-batch consistency was a key factor in the success of our long-term research projects.

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