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Recombinant Human EPHA2
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Cat.No. : | EPHA2-26740TH Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant full length Human Eph receptor A2 with N terminal proprietary tag; Predicted MWt 135.30 kDa inclusive of tag. |
Description : | This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders. |
Protein length : | 976 amino acids |
Molecular Weight : | 135.300kDa inclusive of tags |
Source : | Wheat germ |
Tissue specificity : | Expressed in brain and glioma tissue and glioma cell lines (at protein level). Expressed most highly in tissues that contain a high proportion of epithelial cells, e.g., skin, intestine, lung, and ovary. |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.Contains 2 fibronectin type-III domains.Contains 1 protein kinase domain.Contains 1 SAM (sterile alpha motif) domain. |
Gene Name : | EPHA2 EPH receptor A2 [ Homo sapiens ] |
Official Symbol : | EPHA2 |
Synonyms : | EPHA2; EPH receptor A2; ECK, EphA2; ephrin type-A receptor 2; |
Gene ID : | 1969 |
mRNA Refseq : | NM_004431 |
Protein Refseq : | NP_004422 |
MIM : | 176946 |
Uniprot ID : | P29317 |
Chromosome Location : | 1p36 |
Pathway : | Arf6 signaling events, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Direct p53 effectors, organism-specific biosystem; EPHA forward signaling, organism-specific biosystem; |
Function : | ATP binding; ephrin receptor activity; nucleotide binding; protein binding; receptor activity; |
◆ Recombinant Protein
EPHA2-2515H | Recombinant Human EPHA2 Protein (28-328 aa), His-Myc-tagged | +Inquiry |
Epha2-954M | Recombinant Mouse Epha2 Protein, MYC/DDK-tagged | +Inquiry |
EPHA2-2027H | Recombinant Human EPHA2 Protein, His-tagged | +Inquiry |
EPHA2-3378H | Recombinant Human EPHA2 Protein, GST-tagged | +Inquiry |
EPHA2-321H | Recombinant Human EPHA2 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
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◆ Lysates
EPHA2-2138MCL | Recombinant Mouse EPHA2 cell lysate | +Inquiry |
EPHA2-1072HCL | Recombinant Human EPHA2 cell lysate | +Inquiry |
EPHA2-001HCL | Recombinant Human EPHA2 cell lysate | +Inquiry |
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◆ Assay kits
Kit-0326 | EphA2 Kinase (Human) Assay/Inhibitor Screening Assay Kit | +Inquiry |
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