Recombinant Human EPHA2 EPHA2-26740TH

Recombinant Human EPHA2

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Recombinant Human EPHA2

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Cat.No. : EPHA2-26740TH Optional Service: Optional requirements on this protein
Product Overview : Recombinant full length Human Eph receptor A2 with N terminal proprietary tag; Predicted MWt 135.30 kDa inclusive of tag.
Description : This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.
Protein length : 976 amino acids
Molecular Weight : 135.300kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Expressed in brain and glioma tissue and glioma cell lines (at protein level). Expressed most highly in tissues that contain a high proportion of epithelial cells, e.g., skin, intestine, lung, and ovary.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.Contains 2 fibronectin type-III domains.Contains 1 protein kinase domain.Contains 1 SAM (sterile alpha motif) domain.
Gene Name : EPHA2 EPH receptor A2 [ Homo sapiens ]
Official Symbol : EPHA2
Synonyms : EPHA2; EPH receptor A2; ECK, EphA2; ephrin type-A receptor 2;
Gene ID : 1969
mRNA Refseq : NM_004431
Protein Refseq : NP_004422
MIM : 176946
Uniprot ID : P29317
Chromosome Location : 1p36
Pathway : Arf6 signaling events, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Direct p53 effectors, organism-specific biosystem; EPHA forward signaling, organism-specific biosystem;
Function : ATP binding; ephrin receptor activity; nucleotide binding; protein binding; receptor activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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