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Recombinant Human EPOR Protein, Fc/His-tagged

Cat.No. : EPOR-2045H
Product Overview : Recombinant Human EPO Receptor/EPOR Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Ala25-Pro250) of human EPO Receptor/EPOR (Accession #NP_000112.1) fused with an Fc, 6×His tag at the C-terminus.
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  • Gene Information
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Description : The erythropoietin receptor (EpoR) is a protein that in humans is encoded by the EPOR gene. EpoR is a 52kDa peptide with a single carbohydrate chain resulting in a n approximately 56-57 kDa protein found on the surface of EPO responding cells. It is a member of the cytokine receptor family. EpoR pre-exists as dimers which upon binding of a 30 kDa ligand erythropoietin (Epo), changes its homodimerized state. These conformational changes result in the autophosphorylation of Jak2 kinases that are pre-associated with the receptor (i.e., EpoR does not possess intrinsic kinase activity and depends on Jak2 activity). At present, the most well-established function of EpoR is to promote proliferation and rescue of erythroid (red blood cell) progenitors from apoptosis.
Source : HEK293
Species : Human
Tag : Fc/His
Form : Lyophilized from sterile PBS, pH 7.4, 5 % trehalose, 5 % mannitol.
Protein length : Ala25-Pro250
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : > 90% as determined by SDS-PAGE
Stability : Samples are stable for up to twelve months from date of receipt at -70ºC.
Storage : Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : EPOR erythropoietin receptor [ Homo sapiens ]
Official Symbol : EPOR
Synonyms : EPOR; erythropoietin receptor; EPO-R; MGC138358;
Gene ID : 2057
mRNA Refseq : NM_000121
Protein Refseq : NP_000112
MIM : 133171
UniProt ID : P19235

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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