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| Cat.No.: | EPOR-2045H |
| Product Overview: | Recombinant Human EPO Receptor/EPOR Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Ala25-Pro250) of human EPO Receptor/EPOR (Accession #NP_000112.1) fused with an Fc, 6×His tag at the C-terminus. |
| Description: | The erythropoietin receptor (EpoR) is a protein that in humans is encoded by the EPOR gene. EpoR is a 52kDa peptide with a single carbohydrate chain resulting in a n approximately 56-57 kDa protein found on the surface of EPO responding cells. It is a member of the cytokine receptor family. EpoR pre-exists as dimers which upon binding of a 30 kDa ligand erythropoietin (Epo), changes its homodimerized state. These conformational changes result in the autophosphorylation of Jak2 kinases that are pre-associated with the receptor (i.e., EpoR does not possess intrinsic kinase activity and depends on Jak2 activity). At present, the most well-established function of EpoR is to promote proliferation and rescue of erythroid (red blood cell) progenitors from apoptosis. |
| Source: | HEK293 |
| Species: | Human |
| Tag : | Fc/His |
| Form: | Lyophilized from sterile PBS, pH 7.4, 5 % trehalose, 5 % mannitol. |
| Protein length: | Ala25-Pro250 |
| Endotoxin: | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Purity: | > 90% as determined by SDS-PAGE |
| Stability: | Samples are stable for up to twelve months from date of receipt at -70ºC. |
| Storage: | Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Reconstitution: | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents. |
| Gene Name: | EPOR erythropoietin receptor [ Homo sapiens ] |
| Official Symbol: | EPOR |
| Synonyms: | EPOR; erythropoietin receptor; EPO-R; MGC138358; |
| Gene ID: | 2057 |
| mRNA Refseq: | NM_000121 |
| Protein Refseq: | NP_000112 |
| MIM: | 133171 |
| UniProt ID: | P19235 |
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