EPOR
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Official Full Name
Erythropoietin Receptor
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Overview
This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants. -
Synonyms
EPOR; erythropoietin receptor; EPO-R; MGC138358;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Dog
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- Human
- Human Cell
- In Vitro Cell Free System
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Rabbit
- Wheat Germ
- C
- His
- Fc
- GST
- Avi
- SUMO
- GB1
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
- EPOR Related Signal Pathway
EPOR involved in several pathways and played different roles in them. We selected most pathways EPOR participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPOR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | Flt3l;IRX1;TNFSF13;VEGFC;CLCF1;CCR6;MET;PRLRA;PRL |
| PIK-Akt signaling pathway | MAPK1;YWHAH;IKBKG;ITGA3;IFNA6;RAF1;VEGFA;FN1;PIK3R1 |
| Jak-STAT signaling pathway | IRX1;IFNB1;STAT1;IFNA2;HRAS;CCND2A;PTPN11B;LEP;IFNA12 |
| Hematopoietic cell lineage | ITGAM;Fcer2a;TFRC;Il6ra;HLA-DRA;CD36;CD2;MS4A1;FCER2 |
EPOR has several biochemical functions, for example, erythropoietin receptor activity, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EPOR itself. We selected most functions EPOR had, and list some proteins which have the same functions with EPOR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| erythropoietin receptor activity | |
| identical protein binding | RYR2;RASSF3;SERPINA1A;MMP9;CLDN16;PLDN;AGXT2L1;C1S;CLDN8 |
| protein binding | PLD3;CDCA7L;LAMA4;PER3;GATA1;WRN;GYG1;DLG4;TRIP4 |
EPOR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPOR here. Most of them are supplied by our site. Hope this information will be useful for your research of EPOR.
PTPN6; PTPN1; Cish; INPP5D
Research Area
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