Active Recombinant Human EPOR Protein, His&Avi tagged

• Cat.No.: EPOR-66H
• Product Overview: EpoR dimer protein contains an EpoR extracellular domain (UniProt# P19235) fused with a proprietary dimer motif followed by a tandem His-Avi tag at the C-terminus.

Specification

• Species: Human
• Source: HEK293T
• Tag: Avi&His
• Protein Length: 25-250 aa
• Description: Human erythropoietin receptor (EpoR), also known as EPO-R and CD131, is a transmembrane protein found on the surface of erythropoietin (Epo) responding cells. EpoR belongs to the type I cytokine receptor family. EpoR contains an extracellular domain with two fibronectin type II domains, a transmembrane domain, a juxtamembrane region, and a cytoplasmic region. It functions as a homodimer to form an active receptor complex upon ligand binding that is crucial for receptor activation and downstream signaling. EpoR dysregulation is involved in blood disorders including the development of erythroleukemia and familial erythrocytosis. Therefore, a recombinant protein mimicking the EpoR dimer conformation can be crucial for therapeutic discovery.
• Molecular Mass: 70 kDa
• Homodimer/Heterodimer: Homodimer
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for EpoR specific antibody and erythropoietin (Epo) ligand protein binding assays. Suggested Applications: ELISA for EpoR-specific antibody and erythropoietin (Epo) ligand protein binding assays. SPR & BLI for EpoR-specific antibody and Epo protein binding assays. Animal immunization, RUO.
• Storage: At -80 centigrade
• Storage Buffer: 0.22μm filtered PBS, pH 7.4
• Shipping: Frozen Dry Ice

Gene Information

• Gene Name 2: EPOR erythropoietin receptor [Homo sapiens (human)]
• Official Symbol 2: EPOR
• Synonyms 2: EPOR; erythropoietin receptor; EPO-R; MGC138358
• Gene ID 2: 2057
• mRNA Refseq 2: NM_000121
• Protein Refseq 2: NP_000112
• MIM 2: 133171
• UniProt ID 2: P19235