Recombinant Human ESR1 Protein ESR1-014H

Recombinant Human ESR1 Protein


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Recombinant Human ESR1 Protein

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Cat.No. : ESR1-014H
Product Overview : Recombinant Human ESR1 protein without tag was expressed in E.coli
Description : This gene encodes an estrogen receptor and ligand-activated transcription factor. The canonical protein contains an N-terminal ligand-independent transactivation domain, a central DNA binding domain, a hinge domain, and a C-terminal ligand-dependent transactivation domain. The protein localizes to the nucleus where it may form either a homodimer or a heterodimer with estrogen receptor 2. The protein encoded by this gene regulates the transcription of many estrogen-inducible genes that play a role in growth, metabolism, sexual development, gestation, and other reproductive functions and is expressed in many non-reproductive tissues. The receptor encoded by this gene plays a key role in breast cancer, endometrial cancer, and osteoporosis. This gene is reported to have dozens of transcript variants due to the use of alternate promoters and alternative splicing, however, the full-length nature of many of these variants remain uncertain.
Source : E. coli
Species : Human
Form : Lyophilized powder
Stability : ≥ 1 year
Storage : 4 centigrade
Shipping : Wet ice in continental US, may vary elsewhere.
Gene Name : ESR1 estrogen receptor 1 [ Homo sapiens (human) ]
Official Symbol : ESR1
Synonyms : ESR1; estrogen receptor 1; ER; ESR; Era; ESRA; ESTRR; NR3A1; estrogen receptor; E2 receptor alpha; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; nuclear receptor subfamily 3 group A member 1; oestrogen receptor alpha
Gene ID : 2099
mRNA Refseq : NM_000125
Protein Refseq : NP_000116
MIM : 133430
UniProt ID : P03372

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