Recombinant Human FGF19 Protein, His-tagged
Cat.No. : | FGF19-132H |
Product Overview : | Recombinant Human FGF19 fused with His tag at N-terminal was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Lyophilized from a 0.2 µM filtered solution of PBS, pH 7.4 |
Molecular Mass : | 23.5kD |
AA Sequence : | MGSSHHHHHHSSGLVPRGSHMFSDA GPHVHYGWGDPIRLRHLYTSGPHGL SSCFLRIRADGVVDCARGQSAHSLL EIKAVALRTVAIKGVHSVRYLCMGA DGKMQGLLQYSEEDCAFEEEIRPDG YNVYRSEKHRLPVSLSSAKQRQLYK NRGFLPLSHFLPMLPMVPEEPEDLR GHLESDMFSSPLETDSMDPFGLVTG LEAVRSPSFEK |
Endotoxin : | Endotoxin level is <0.1 ng/µg of protein (<1EU/µg). |
Purity : | >95% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Gene Name : | FGF19 fibroblast growth factor 19 [ Homo sapiens ] |
Official Symbol : | FGF19 |
Synonyms : | FGF19; fibroblast growth factor 19; FGF-19; |
Gene ID : | 9965 |
mRNA Refseq : | NM_005117 |
Protein Refseq : | NP_005108 |
MIM : | 603891 |
UniProt ID : | O95750 |
Products Types
◆ Recombinant Protein | ||
FGF19-1484H | Recombinant Human FGF19 Protein, His-tagged | +Inquiry |
FGF19-4109H | Recombinant Human FGF19 Protein, GST-tagged | +Inquiry |
FGF19-1485H | Recombinant Human FGF19 Protein, His-tagged | +Inquiry |
FGF19-7336H | Recombinant Human FGF19 protein(Phe27-Lys216) | +Inquiry |
FGF19-75H | Recombinant Active Human FGF19 Protein, His-tagged(C-ter) | +Inquiry |
◆ Lysates | ||
FGF19-6244HCL | Recombinant Human FGF19 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionFGF19 expression is regulated by bile acids and other factors. Its secretion and activity are influenced by nutrient availability, signaling pathways, and interactions with bile acid receptors.
Targeting FGF19 holds therapeutic potential for metabolic disorders. Challenges include achieving tissue-specific effects and understanding the long-term consequences of manipulating FGF19 signaling.
FGF19 regulates bile acid synthesis in the liver and influences the enterohepatic circulation, impacting metabolic health by modulating lipid and glucose metabolism.
FGF19 influences gut hormone secretion, including the release of glucagon-like peptide-1 (GLP-1). This regulation contributes to its metabolic effects, such as enhanced insulin sensitivity and reduced food intake.
Dysregulation of FGF19 is implicated in metabolic diseases, including obesity and NAFLD. Altered FGF19 signaling may contribute to aberrant bile acid and lipid metabolism in these conditions.
Customer Reviews (3)
Write a reviewTop-notch protein quality! It's our go-to for reliable and reproducible results.
This product simplifies our research. It's a reliable tool that we can count on.
If you're in the lab, you need this product. It streamlines processes and is a lab necessity.
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