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Recombinant Human FMR1 Protein, GST-tagged

Cat.No. : FMR1-4396H
Product Overview : Human FMR1 full-length ORF ( AAH38998.1, 1 a.a. - 297 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5 UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). [provided by RefSeq
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 58.41 kDa
AA Sequence : MEELVVEVRGSNGAFYKAFVKDVHE DSITVAFENNWQPDRQIPFHDVRFP PPVGYNKDINESDEVEVYSRANEKE PCCWWLAKVRMIKGEFYVIEYAACD ATYNEIVTIERLRSVNPNKPATKDT FHKIKLDVPEDLRQMCAKEAAHKDF KKAVGAFSVTYDPENYQLVILSINE VTSKRAHMLIDMHFRSLRTKLSLIM RNEEASKQLESSRQLASRFHEQFIV REDLMGLAIGTHGANIQQARKVPGV TAIDLDEDTCTFHIYGEDQDAVKKA RSFLEFAEDVIQVPRNLVGLKI
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : FMR1 fragile X mental retardation 1 [ Homo sapiens ]
Official Symbol : FMR1
Synonyms : FMR1; fragile X mental retardation 1; POF, POF1, premature ovarian failure 1; fragile X mental retardation protein 1; FMRP; FRAXA; MGC87458; protein FMR-1; fragile X mental retardation 1 protein; POF; POF1;
Gene ID : 2332
mRNA Refseq : NM_001185075
Protein Refseq : NP_001172004
MIM : 309550
UniProt ID : Q06787

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the impact of FMR1 mutations on behavioral and emotional regulation? 09/05/2022

Mutations in FMR1 can impact emotional and behavioral regulation, contributing to mood and behavioral disorders.

What role does FMR1 play in cognitive development and learning processes? 04/24/2022

FMR1 plays a critical role in cognitive development, influencing how the brain processes and stores information.

How does FMR1 deficiency lead to Fragile X syndrome and associated symptoms? 03/14/2022

FMR1 deficiency causes Fragile X syndrome, leading to intellectual disability and developmental delays.

How does FMR1 influence the development of autism spectrum disorders and related neurodevelopmental conditions? 01/03/2022

FMR1 is associated with autism spectrum disorders, affecting brain development and social-communication skills.

How does FMR1 (Fragile X Mental Retardation 1) gene regulate synaptic function and neuronal plasticity? 10/29/2020

FMR1 is key in regulating synaptic function and plasticity, essential for learning and memory.

How do alterations in FMR1 expression or function affect reproductive health, particularly in relation to Fragile X-associated disorders? 11/14/2019

Changes in FMR1 can affect reproductive health, particularly in carriers of Fragile X mutations, impacting fertility and genetic risks.

What are the mechanisms by which FMR1 modulates gene expression and protein synthesis in neurons? 02/27/2019

FMR1 modulates gene expression and protein synthesis in neurons, crucial for normal brain function.

Customer Reviews (3)

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Reviews
03/04/2019

    Efficient peptide synthesis, crucial for our peptide research projects.

    03/01/2019

      Precise mass spectrometry analysis, essential for our proteomics work.

      04/07/2018

        Exceptional protein engineering services, our trusted research partner.

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