Recombinant Human FMR1 protein, MYC/DDK-tagged

• Cat.No.: FMR1-446H
• Product Overview: Recombinant Human FMR1 fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 71 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: FMR1 fragile X mental retardation 1 [ Homo sapiens ]
• Official Symbol: FMR1
• Synonyms: FMR1; fragile X mental retardation 1; POF, POF1, premature ovarian failure 1; fragile X mental retardation protein 1; FMRP; FRAXA; MGC87458; protein FMR-1; fragile X mental retardation 1 protein; POF; POF1
• Gene ID: 2332
• mRNA Refseq: NM_002024
• Protein Refseq: NP_002015
• MIM: 309550
• UniProt ID: Q06787
• Chromosome Location: Xq27.3
• Pathway: RNA transport, organism-specific biosystem; RNA transport, conserved biosystem
• Function: RNA binding; RNA binding; mRNA binding; protein binding