Recombinant Human Fms-Related Tyrosine Kinase 3, GST-tagged
Cat.No. : | FLT3-1016H |
Product Overview : | Recombinant human FLT3 (571-993) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag. |
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Cat. No. : | FLT3-1016H |
Description : | FLT3 is a receptor tyrosine kinase that has been shown to play a role in proliferation and survival of hematopoietic progenitor cells as well as differentiation of early B lymphoid progenitors. FLT3 consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. FLT3 is the most frequently mutated gene in cases of acute myelogenous leukemia (AML). |
Applications : | Kinase Assay; Western Blot |
Molecular Weight : | 73 kDa |
Expression System : | Sf9 insect cells using baculovirus |
Species : | Human |
Form : | Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol. |
Specific Activity : | 70 nmol/min/mg |
Purity : | >75% |
Concentration : | 0.1 ug/ul |
Sequences : | 571-993 |
Storage : | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Pathways : | Cytokine-cytokine receptor interaction; Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Pathways in cancer |
Protein length : | 571-993 |
Gene Name : | FLT3 fms-related tyrosine kinase 3 [ Homo sapiens ] |
Official Symbol : | FLT3 |
Synonyms : | FLT3; fms-related tyrosine kinase 3; FLK2; STK1; CD135; FL cytokine receptor; FLT-3; STK-1; CD135 antigen; OTTHUMP00000018181; OTTHUMP00000214829; fetal liver kinase 2; fms-like tyrosine kinase 3; stem cell tyrosine kinase 1; FLT3 receptor tyrosine kinase; tyrosine-protein kinase receptor FLT3; growth factor receptor tyrosine kinase type III |
Gene ID : | 2322 |
mRNA Refseq : | NM_004119 |
Protein Refseq : | NP_004110 |
MIM : | 136351 |
UniProt ID : | P36888 |
Chromosome Location : | 13q12 |
Function : | ATP binding; nucleotide binding; phosphoinositide 3-kinase binding; protein binding; receptor activity; transferase activity; vascular endothelial growth factor receptor activity |
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◆ Lysates | ||
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewExcellent product, great price.
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Q&As (7)
Ask a questionFLT3 is frequently mutated in AML, contributing to uncontrolled cell growth and poor prognosis.
FLT3 is predominantly expressed in hematopoietic stem cells and progenitor cells.
It is essential for hematopoiesis, particularly in the proliferation of early progenitor cells.
Therapeutic strategies include FLT3 inhibitors, showing effectiveness in treating AML patients with FLT3 mutations.
FLT3 is a receptor tyrosine kinase that plays a crucial role in cell survival, proliferation, and differentiation.
It stimulates the proliferation and differentiation of hematopoietic stem cells, guiding their development into various blood cell types.
Common mutations include internal tandem duplications (ITD) and tyrosine kinase domain (TKD) mutations, leading to constitutive activation of FLT3.
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