| Description : |
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Fc |
| Form : |
Lyophilized |
| Molecular Mass : |
43.3 kDa |
| Protein Length : |
574 |
| AA Sequence : |
MRDPGAAAPLSSLGLCALVLALLGA LSAGAGAQPYHGEKGISVPDHGFCQ PISIPLCTDIAYNQTILPNLLGHTN QEDAGLEVHQFYPLVKVQCSPELRF FLCSMYAPVCTVLDQAIPPCRSLCE RARQGCEALMNKFGFQWPERLRCEN FPVHGAGEICVGQNTSDGSGGPGGG PTAYPTAPYLPDLPFTALPPGASDG RGRPAFPFSCPRQLKVPPYLGYRFL GERDCGAPCEPGRANGLMYFKEEER RFARLWVGVWSVLCCASTLFTVLTY LVDMRRFSYPERPIIFLSGCYFMVA VAHVAGFLLEDRAVCVERFSDDGYR TVAQGTKKEGCTILFMVLYFFGMAS SIWWVILSLTWFLAAGMKWGHEAIE ANSQYFHLAAWAVPAVKTITILAMG QVDGDLLSGVCYVGLSSVDALRGFV LAPLFVYLFIGTSFLLAGFVSLFRI RTIMKHDGTKTEKLEKLMVRIGVFS VLYTVPATIVLACYFYEQAFREHWE RTWLLQTCKSYAVPCPPGHFPPMSP DFTVFMIKYLMTMIVGITTGFWIWS GKTLQSWRRFYHRLSHSSKGETAV |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
