Recombinant Human GALC Protein, GST-tagged

• Cat.No.: GALC-4676H
• Product Overview: Human GALC full-length ORF ( AAH36518, 27 a.a. - 669 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a lysosomal protein which hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Mutations in this gene have been associated with Krabbe disease, also known as globoid cell leukodystrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 96.47 kDa
• AA Sequence: YVLDDSDGLGREFDGIGAVSGGGAT SRLLVNYPEPYRSQILDYLFKPNFG ASLHILKVEIGGDGQTTDGTEPSHM HYALDGNYFRGYEWWLMKEAKKRNP NITLIGLPWSFPGWLGKGFDWPYVN LQLTAYYVVTWIVGAKRYHDLDIDY IGIWNERSYNANYIKILRKMLNYQG LQRVKIIASDNLWESISASMLLDAE LFKVVDVIGAHYPGTHSAKDAKLTG KKLWSSEDFSTLNSDMGAGCWGRIL NQNYINGYMTSTIAWNLVASYYEQL PYGRCGLMTAQEPWSGHYVVESPVW VSAHTTQFTQPGWYYLKTVGHLEKG GSYVALTDGLGNLTIIIETMSHKHS KCIRPFLPYFNVSQQFATFVLKGSF SEIPELQVWYTKLGKTSERFLFKQL DSLWLLDSDGSFTLSLHEDELFTLT TLTTGRKGSYPLPPKSQPFPSTYKD DFNVDYPFFSEAPNFADQTGVFEYF TNIEDPGEHHFTLRQVLNQRPITWA ADASNTISIIGDYNWTNLTTKCDVY IETPDTGGVFIAGRVNKGGILIRSA RGIFFWIFANGSYRVTGDLAGWIIY ALGRVEVTAKKWYTLTLTIKGHFAS GMLNDKSLWTDIPVNFPKNGWAAIG THSFEFAQFDNFRVEATR
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: GALC galactosylceramidase [ Homo sapiens ]
• Official Symbol: GALC
• Synonyms: GALC; galactosylceramidase; galactosylceramidase (Krabbe disease); galactocerebrosidase; Krabbe disease; GALCERase; galactosylceraminidase; galactocerebroside beta-galactosidase; galactosylceramide beta-galactosidase
• Gene ID: 2581
• mRNA Refseq: NM_000153
• Protein Refseq: NP_000144
• MIM: 606890
• UniProt ID: P54803