Recombinant Human GDF15 Protein (Ala197-Ile308), His tagged
Cat.No. : | GDF15-3309H |
Product Overview : | Recombinant human GDF15 (Ala197-Ile308) protein fused with His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Growth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF) -β superfamily, as a novel antihypertrophic regulatory factor in the heart. GDF-15/GDF15 is not expressed in the normal adult heart but is induced in response to conditions that promote hypertrophy and dilated cardiomyopathy and it is expressed highly in liver. GDF-15/GDF15 has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF-15/GDF15 is synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein. GDF-15/GDF15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Molecular Mass : | 14.05 kDa |
Protein Length : | Ala197-Ile308 |
Purity : | >90 % as determined by SDS-PAGE. |
Notes : | For research use only. |
Storage : | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt. |
Storage Buffer : | Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5. |
Reconstitution : | Reconstitute in sterile water for a stock solution. |
Shipping : | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
Gene Name : | GDF15 growth differentiation factor 15 [ Homo sapiens (human) ] |
Official Symbol : | GDF15 |
Synonyms : | GDF15; growth differentiation factor 15; growth/differentiation factor 15; MIC 1; MIC1; NAG 1; PDF; PLAB; prostate differentiation factor; PTGFB; NRG-1; PTGF-beta; placental TGF-beta; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; macrophage inhibitory cytokine 1; placental bone morphogenetic protein; NSAID (nonsteroidal anti-inflammatory drug) -activated protein 1; MIC-1; NAG-1; GDF-15; |
Gene ID : | 9518 |
mRNA Refseq : | NM_004864 |
Protein Refseq : | NP_004855 |
MIM : | 605312 |
UniProt ID : | Q99988 |
Products Types
◆ Recombinant Protein | ||
GDF15-4822H | Recombinant Human GDF15 Protein, GST-tagged | +Inquiry |
GDF15-204H | Recombinant Human GDF15 protein(Ala197-Ile308), hFc-tagged | +Inquiry |
Gdf15-01M | Active Recombinant Mouse Gdf15 Protein, Fc-tagged | +Inquiry |
GDF15-2158R | Recombinant Rat GDF15 Protein, His (Fc)-Avi-tagged | +Inquiry |
GDF15-946H | Recombinant Human GDF15 Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
GDF15-27680TH | Active Native Human GDF15 Protein | +Inquiry |
◆ Lysates | ||
GDF15-2705HCL | Recombinant Human GDF15 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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