| Description : |
This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
His |
| Form : |
Lyophilized |
| Molecular Mass : |
45.5 kDa |
| Protein Length : |
465 |
| AA Sequence : |
MFLATLYFALPLLDLLLSAEVSGGD RLDCVKASDQCLKEQSCSTKYRTLR QCVAGKETNFSLASGLEAKDECRSA MEALKQKSLYNCRCKRGMKKEKNCL RIYWSMYQSLQGNDLLEDSPYEPVN SRLSDIFRVVPFISDVFQQVEHIPK GNNCLDAAKACNLDDICKKYRSAYI TPCTTSVSNDVCNRRKCHKALRQFF DKVPAKHSYGMLFCSCRDIACTERR RQTIVPVCSYEEREKPNCLNLQDSC KTNYICRSRLADFFTNCQPESRSVS SCLKENYADCLLAYSGLIGTVMTPN YIDSSSLSVAPWCDCSNSGNDLEEC LKFLNFFKDNTCLKNAIQAFGNGSD VTVWQPAFPVQTTTATTTTALRVKN KPLGPAGSENEIPTHVLPPCANLQA QKLKSNVSGNTHLCISNGNYEKEGL GASSHITTKSMAAPPSCGLSPLLVL VVTALSTLLSLTETS |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
