Description : |
The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function of huntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of hematopoietic malignancies. Two transcript variants encoding different isoforms have been found for this gene. |
Protein length : |
1037 amino acids |
Molecular Weight : |
140.140kDa inclusive of tags |
Source : |
Wheat germ |
Tissue specificity : |
Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer. |
Form : |
Liquid |
Purity : |
Proprietary Purification |
Storage buffer : |
pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
Storage : |
Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : |
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQ TVSINKAINTQEVAVKEKHARTCILGTHHEKGAQTFWSVV NRLPLSSNAVLCWKFCHVFHKLLRDGHPNVLKDSLRYRNE LSDMSRMWGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFP GNLQMSDRQLDEAGESDVNNFFQLTVEMFDYLECELNLFQ TVFNSLDMSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTV KLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQ YFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEASS PDSEPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPF NFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQR VVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDEL RRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQ NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERI SDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSA QSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQD TQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALN QLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLA CPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADS LTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKI KAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATAR IEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVA SKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVG WGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAA SKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQI EETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQK LGELRKKHYELAGVAEGWEEGTEASPPTLQEVVTEKE |
Sequence Similarities : |
Belongs to the SLA2 family.Contains 1 ENTH (epsin N-terminal homology) domain.Contains 1 I/LWEQ domain. |