Recombinant Human HIP1

• Cat.No.: HIP1-28314TH
• Product Overview: Recombinant full length Human Huntingtin Interacting Protein HIP1 with N terminal proprietary tag; Predicted MWt 140.14 kDa.

Specification

• Species: Human
• Source: Wheat Germ
• Tag: Non
• Protein Length: 1037 amino acids
• Description: The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function of huntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of hematopoietic malignancies. Two transcript variants encoding different isoforms have been found for this gene.
• Molecular Weight: 140.140kDa inclusive of tags
• Tissue specificity: Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQ TVSINKAINTQEVAVKEKHARTCILGTHHEKGAQTFWSVV NRLPLSSNAVLCWKFCHVFHKLLRDGHPNVLKDSLRYRNE LSDMSRMWGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFP GNLQMSDRQLDEAGESDVNNFFQLTVEMFDYLECELNLFQ TVFNSLDMSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTV KLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQ YFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEASS PDSEPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPF NFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQR VVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDEL RRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQ NHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERI SDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSA QSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQD TQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALN QLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLA CPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADS LTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKI KAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATAR IEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVA SKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVG WGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAA SKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQI EETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQK LGELRKKHYELAGVAEGWEEGTEASPPTLQEVVTEKE
• Sequence Similarities: Belongs to the SLA2 family.Contains 1 ENTH (epsin N-terminal homology) domain.Contains 1 I/LWEQ domain.

Gene Information

• Gene Name: HIP1 huntingtin interacting protein 1 [ Homo sapiens ]
• Official Symbol: HIP1
• Synonyms: HIP1; huntingtin interacting protein 1; huntingtin-interacting protein 1; ILWEQ
• Gene ID: 3092
• mRNA Refseq: NM_001243198
• Protein Refseq: NP_001230127
• MIM: 601767
• Uniprot ID: O00291
• Chromosome Location: 7q11.23
• Pathway: Coregulation of Androgen receptor activity, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Huntingtons disease, organism-specific biosystem; Huntingtons disease, conserved biosystem
• Function: actin binding; clathrin binding; phosphatidylinositol binding; protein binding; structural constituent of cytoskeleton