Recombinant Human HIP1 Protein, GST-tagged

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Recombinant Human HIP1 Protein, GST-tagged

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Cat.No. : HIP1-4755H
Product Overview : Human HIP1 full-length ORF ( NP_005329.3, 1 a.a. - 1037 a.a.) recombinant protein with GST-tag at N-terminal.
Description : The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function of huntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of hematopoietic malignancies. An alternative splice variant of this gene has been described but its full length sequence has not been determined. [provided by RefSeq
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 142.6 kDa
AA Sequence : MDRMASSMKQVPNPL PKVLSRRGVGAGLEA AERESFERTQTVSIN KAINTQEVAVKEKHA RTCILGTHHEKGAQT FWSVVNRLPLSSNAV LCWKFCHVFHKLLRD GHPNVLKDSLRYRNE LSDMSRMWGHLSEGY GQLCSIYLKLLRTKM EYHTKNPRFPGNLQM SDRQLDEAGESDVNN FFQLTVEMFDYLECE LNLFQTVFNSLDMSR SVSVTAAGQCRLAPL IQVILDCSHLYDYTV KLLFKLHSCLPADTL QGHRDRFMEQFTKLK DLFYRSSNLQYFKRL IQIPQLPENPPNFLR ASALSEHISPVVVIP AEASSPDSEPVLEKD DLMDMDASQQNLFDN KFDDIFGSSFSSDPF NFNSQNGVNKDEKDH LIERLYREISGLKAQ LENMKTESQRVVLQL KGHVSELEADLAEQQ HLRQQAADDCEFLRA ELDELRRQREDTEKA QRSLSEIERKAQANE QRYSKLKEKYSELVQ NHADLLRKNAEVTKQ VSMARQAQVDLEREK KELEDSLERISDQGQ RKTQEQLEVLESLKQ ELATSQRELQVLQGS LETSAQSEANWAAEF AELEKERDSLVSGAA HREEELSALRKELQD TQLKLASTEESMCQL AKDQRKMLLVGSRKA AEQVIQDALNQLEEP PLISCAGSADHLLST VTSISSCIEQLEKSW SQYLACPEDISGLLH SITLLAHLTSDAIAH GATTCLRAPPEPADS LTEACKQYGRETLAY LASLEEEGSLENADS TAMRNCLSKIKAIGE ELLPRGLDIKQEELG DLVDKEMAATSAAIE TATARIEEMLSKSRA GDTGVKLEVNERILG CCTSLMQAIQVLIVA SKDLQREIVESGRGT ASPKEFYAKNSRWTE GLISASKAVGWGATV MVDAADLVVQGRGKF EELMVCSHEIAASTA QLVAASKVKADKDSP NLAQLQQASRGVNQA TAGVVASTISGKSQI EETDNMDFSSMTLTQ IKRQEMDSQVRVLEL ENELQKERQKLGELR KKHYELAGVAEGWEE GTEASPPTLQEVVTE KE
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Quality Control Testing :

12.5% SDS-PAGE Stained with Coomassie Blue.

Gene Name : HIP1 huntingtin interacting protein 1 [ Homo sapiens ]
Official Symbol : HIP1
Synonyms : HIP1; huntingtin interacting protein 1; huntingtin-interacting protein 1; ILWEQ; HIP-I; huntingtin-interacting protein I; MGC126506;
Gene ID : 3092
mRNA Refseq : NM_001243198
Protein Refseq : NP_001230127
MIM : 601767
UniProt ID : O00291

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