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Recombinant Human Human PIK3CB, His-tagged

Cat.No. : PIK3R1-31096TH
Product Overview : Recombinant full-length Human PIK3CB and PIK3R1 were co-expressed by baculovirus in Sf9 insect cells using an N-terminal His tag on both proteins, MWt 111 and86kDa respectively.
  • Specification
  • Gene Information
  • Related Products
Description : Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms.
Conjugation : HIS
Biological activity : The Specific activity of PIK3R1-31096TH was determined to be 16.3 nmol/min/mg.
Form : Liquid
Storage buffer : Preservative: 150mM ImidazoleConstituents: 25% Glycerol, 50mM Sodium phosphate, 300mM Sodium chloride, 2mM DTT, 0.1mM PMSF, pH 7.0
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Gene Name : PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [ Homo sapiens ]
Official Symbol : PIK3R1
Synonyms : PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); phosphatidylinositol 3-kinase regulatory subunit alpha; GRB1; p85; p85 ALPHA;
Gene ID : 5295
mRNA Refseq : NM_001242466
Protein Refseq : NP_001229395
MIM : 171833
Uniprot ID : P27986
Chromosome Location : 5q13.1
Pathway : 3-phosphoinositide biosynthesis, conserved biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adaptive Immune System, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, organism-specific biosystem;
Function : 1-phosphatidylinositol binding; ErbB-3 class receptor binding; insulin binding; insulin receptor binding; insulin receptor substrate binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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