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Recombinant Human IFNGR1, Fc-tagged

Cat.No. : IFNGR1-28503TH
Product Overview : Recombinant fragment, corresponding to the extracellular domain (amino acids 18-245) of Human IFNGR1 fused to the Fc region of Human IgG1 (aa 93-330). The chimeric protein was expressed in modified Human 293 cells.
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Description : This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection.
Conjugation : Fc
Biological activity : The ED50 of IFNGR1 (Fc Chimera) is typically 0.05-0.1 μg/ml as measured by its ability to neutralize IFN gamma mediated cytotoxicity using the HT-29 colorectal adenocarcinoma cell line.
Form : Lyophilised:It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not reco
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 10% Trehalose, 1% Human serum albumin
Storage : Store at +4°C.
Sequences of amino acids : Theoretical sequence: EMGTADLGPSSVPTPTNVTIESYNM NPIVYWEYQIMPQ VPVFTVEVKNYGVKNSEWIDACINI SHHYCNISDHVGD PSNSLWVRVKARVGQKESAYAKSEE FAVCRDGKIGPPK LDIRKEEKQIMIDIFHPSVFVNGDE QEVDYDPETTCYI RVYNVYVRMNGSEIQYKILTQKEDD CDEIQCQLAIPVSSLNSQYCVSAEG VLHVWGVTTEKSKEVCITIFNSSIK GGS SNTKVDKKVEPKSCDKTHTCPPCPA PELLGGPSVFLFP PKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGV EVHNAKTKPREEQYNSTYRVVSVLT VLHQDWLNGKEYK CKVSNKALPAPIEKTISKAKGQPRE PQVYTLPPSRDELTKNQVSLTCLVK GFYPSDIAVEWESNGQPENNYKTTP PVL DSDGSFFLYSKLTVDKSRWQQGNVF SCSVMHEALHNHY TQKSLSLSPGK
Sequence Similarities : Belongs to the type II cytokine receptor family.Contains 2 fibronectin type-III domains.Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Protein length : 18-245
Gene Name : IFNGR1 interferon gamma receptor 1 [ Homo sapiens ]
Official Symbol : IFNGR1
Synonyms : IFNGR1; interferon gamma receptor 1; IFNGR; CD119;
Gene ID : 3459
mRNA Refseq : NM_000416
Protein Refseq : NP_000407
MIM : 107470
Uniprot ID : P15260
Chromosome Location : 6q23-q24
Pathway : Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;
Function : cytokine binding; interferon-gamma receptor activity; receptor activity;

Not For Human Consumption!

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