IFNGR1

  • Official Full Name

    IFNGR1 interferon gamma receptor 1

  • Overview

    It reacts with CD119, the alpha chain of the interferon gamma (IFN-gamma) receptor. This receptor is expressed by mouse leukocytes, endothelial, and epithelial cells, but not by mature erythrocytes. This antibody recognizes an epitope (susceptible to certain fixatives) in the ligand-binding site of the receptor. It can block the binding of mouse IFN-gamma; therefore, it can inhibit IFN-gamma mediated effects including the activation of mouse macrophages for tumor cell killing. IFN-gamma has been reported to induce the expression of Ly-6A/E antigen on cell lines and normal B lymphocytes, and the antibody is capable of inhibiting the IFN-gamma.induced expression of Ly-6A/E on the mouse B lymphoma line A20. The binding of the antibody to CD119 is inhibited by IFN-gamma. This antibody reportedly does not have any agonist effect.
  • Synonyms

    IFNGR1; interferon gamma receptor 1; IFNGR; CD119; CDw119; AVP, type 2; IFN-gamma-R1; CD119 antigen; IFN-gamma receptor 1; antiviral protein, type 2; immune interferon receptor 1; interferon-gamma receptor alpha chain; FLJ45734;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rhesus Macaque
  • Rhesus monkey
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • C
  • Fc
  • hFc
  • His
  • Myc
  • DDK
  • Fc|His
  • Flag
  • GST
  • hIgG1
  • hIgG4
  • His (Fc)
  • Avi
  • His|T7
  • human|IgG1|Fc
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IFNGR1-596 Active Recombinant Human Interferon Gamma Receptor 1 Sf9 Insect Cell N/A
Human IFNGR1-22H Active Recombinant Human Interferon Gamma Receptor 1, Fc Chimera HEK293 Fc
Human IFNGR1-2250H Active Recombinant Human IFNGR1 protein, His-tagged HEK293 His Met 1-Gly 245
Human IFNGR1-612H Recombinant Human IFNGR1, Fc-His tagged Human Cell Fc/His
Human IFNGR1-143H Recombinant Human IFNGR1 Mammalian Cell His
Human IFNGR1-57H Recombinant Human Interferon Gamma Receptor 1 Mammalian cells N/A
Human IFNGR1-28503TH Recombinant Human IFNGR1, Fc-tagged Fc
Human IFNGR1-116H Recombinant Human IFNGR1 protein E.coli N/A
Human IFNGR1-7038H Recombinant Human IFNGR1 protein, His & T7-tagged E.coli His/T7 Glu18~Gly245 (Accession # P15260)
Human IFNGR1-2646HCL Recombinant Human IFNGR1 cell lysate Human Cell N/A
Human IFNGR1-389H Recombinant Human IFNGR1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human IFNGR1-1151H Recombinant Human IFNGR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IFNGR1-1186H Recombinant Human IFNGR1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human IFNGR1-297H Recombinant Human IFNGR1 Protein, His-tagged HEK293 His 489
Human IFNGR1-062H Recombinant Human IFNGR1 Protein, C-His-tagged E.coli C-His
Human IFNGR1-298H Recombinant Human IFNGR1 Protein, Fc-tagged HEK293 Fc 489
Human IFNGR1-001H Recombinant Human IFNGR1 Protein, His-tagged Insect Cell His
Human IFNGR1-2405H Recombinant Human IFNGR1 Protein (Glu18-Ser245), C-His tagged Mammalian cells C-His Glu18-Ser245
Human IFNGR1-1061HFL Recombinant Full Length Human IFNGR1 Protein, C-Flag-tagged Mammalian cells Flag
Human IFNGR1-381H Recombinant Human IFNGR1 protein, Fc-tagged HEK293 human/IgG1/Fc 228
Human IFNGR1-1151H-B Recombinant Human IFNGR1 Protein Pre-coupled Magnetic Beads HEK293
Human IFNGR1-1591H Active Recombinant Human IFNGR1 protein, Fc-tagged HEK293 Fc Lys28-Lys436
Human IFNGR1-1590H Active Recombinant Human IFNGR1 protein, His-tagged HEK293 His Lys28-Lys436
Human IFNGR1-4253H Recombinant Human IFNGR1 Protein (Met1-Gly245), C-His tagged Mammalian cells C-His Met1-Gly245
Human IFNGR1-1204H Recombinant Human IFNGR1 Protein (Glu18-Gly245), N-His tagged E.coli N-His Glu18-Gly245
Mouse Ifngr1-7039M Recombinant Mouse Ifngr1 protein, GST-tagged E.coli GST Gly23~Asp253
Mouse Ifngr1-1748M Recombinant Mouse Interferon Gamma Receptor 1, Fc-tagged Mammalian cells Fc
Mouse Ifngr1-6953M Active Recombinant Mouse Ifngr1 protein, hFc-tagged HEK293 hFc Met1-Asp253
Mouse Ifngr1-6954M Active Recombinant Mouse Ifngr1 protein(Met1-Asp253), His-tagged HEK293 C-His Met1-Asp253
Mouse IFNGR1-1775MCL Recombinant Mouse IFNGR1 cell lysate Human Cell N/A
Mouse Ifngr1-5687M Recombinant Mouse Ifngr1 Protein (Ala26-Asp253), C-Fc tagged Mammalian cells C-Fc Ala26-Asp253
Mouse Ifngr1-1218M Recombinant Mouse Ifngr1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Ifngr1-1652M Recombinant Mouse Ifngr1 Protein, His-tagged E.coli N-His Gly23-Asp253
Mouse Ifngr1-60M-B Recombinant Mouse Ifngr1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ifngr1-5688M Recombinant Mouse Ifngr1 Protein (Ala26-Asp253), C-His tagged Mammalian cells C-His Ala26-Asp253
Mouse Ifngr1-60M Recombinant Mouse Ifngr1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse IFNGR1-1589M Active Recombinant Mouse IFNGR1 protein, His-tagged HEK293 His Glu27-Thr429
Rat IFNGR1-2347R Recombinant Rat IFNGR1 protein(Met1-Ser241), hFc-tagged HEK293 C-hFc Met1-Ser241
Rat Ifngr1-8732R Recombinant Rat Ifngr1, Fc tagged Human Cell N/A
Rat IFNGR1-1175RCL Recombinant Rat IFNGR1 cell lysate Human Cell N/A
Rhesus monkey IFNGR1-1550R Recombinant Rhesus Monkey IFNGR1 Protein HEK293 N/A
Rhesus monkey IFNGR1-1551R Recombinant Rhesus Monkey IFNGR1 Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey IFNGR1-1552R Recombinant Rhesus Monkey IFNGR1 Protein, hIgG4-tagged HEK293 hIgG4
Cynomolgus Monkey IFNGR1-1207C Active Recombinant Cynomolgus IFNGR1 Protein, Fc-tagged HEK293 Fc
Cynomolgus Monkey IFNGR1-105C Recombinant Cynomolgus IFNGR1, His tagged Human Cell His
Cynomolgus Monkey IFNGR1-1003CCL Recombinant Cynomolgus IFNGR1 cell lysate Human Cell N/A
Homo sapiens (Human) RFL22349HF Recombinant Full Length Human Interferon Gamma Receptor 1(Ifngr1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (18-489)
Mus musculus (Mouse) RFL15391MF Recombinant Full Length Mouse Interferon Gamma Receptor 1(Ifngr1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (26-477)
Rhesus Macaque IFNGR1-2208R Recombinant Rhesus monkey IFNGR1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque IFNGR1-2029R Recombinant Rhesus Macaque IFNGR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque IFNGR1-2029R-B Recombinant Rhesus Macaque IFNGR1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish IFNGR1-7671Z Recombinant Zebrafish IFNGR1 Mammalian Cell His
Chicken IFNGR1-3852C Recombinant Chicken IFNGR1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • IFNGR1 Related Signal Pathway

IFNGR1 involved in several pathways and played different roles in them. We selected most pathways IFNGR1 participated on our site, such as Cytokine-cytokine receptor interaction, HIF- signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFNGR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCXCR5;CXCL12A;IFNA12;CCL7;CCL18;CCL4;BMPR1B;GM2002;IL24
HIF- signaling pathwayEGLN1;PRKCB;ENO1;IFNGR1;CAMK2A;PIK3CB;NOX1;NOX3;INS1
Osteoclast differentiationIKBKG;TGFBR1;LCK;CYBA;ACP5;LILRA5;CYBB;TNF;MAPK3
Jak-STAT signaling pathwayIL7;PIK3R1;IFNGR1;STAT3;CSH;STAT5A;IFNA2;IL2RGA;IFNG
Natural killer cell mediated cytotoxicityIFNA17;ITGB2L;BID;LCP2;KLRC2;Raet1c;TNF;RAC1;KIR2DS3
Salmonella infectionMYD88;DYNC1LI2;PFN2L;IL1A;MAPK13;ROCK1;MAPK10;ACTB2;ROCK2A
LeishmaniasisITGB2L;TRAF6;IFNG;TLR4;IRAK1;IL4;TGFB1;HLA-DPB1;IRAK4
Chagas disease (American trypanosomiasis)PIK3CG;TNF;SMAD2;CD3E;IKBKB;IFNB1;MAPK11;TRAF6;PLCB3
ToxoplasmosisPIK3CG;BAD;IL12A;HLA-DRA;MAP3K7;PIK3CB;ITGB1;LAMC1;TNF
TuberculosisRAB5B;NOS2;PPP3R2;SRC;CASP10;IFNA17;H2-AB1;NFYC;CALM1
MeaslesTACR1;PIK3CG;MAP3K7;Fasl;EIF2AK4;IFNB1;IRAK1;OAS2;CD3E; CD3D
Influenza ANFKBIB;RELA;EIF2AK2;IL12A;TLR4;IFN-a;PIK3CD;TNFRSF10A;HLA-DQA1
Herpes simplex infectionGTF2IRD1;PPP1CB;STAT1A;SRSF2;PPP1CAA;IFNPHI1;MAP3K7;SKP2;IFNA7
Inflammatory bowel disease (IBD)IL18R1;TGFB2;IL12A;HLA-DQA2;STAT6;Il23a; Il12b;TLR2;H2-AB1;IFNG

IFNGR1 has several biochemical functions, for example, cytokine binding, interferon-gamma receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFNGR1 itself. We selected most functions IFNGR1 had, and list some proteins which have the same functions with IFNGR1. You can find most of the proteins on our site.

Function Related Protein
cytokine bindingIL31RA;NRP2;LIFR;IFNGR1;KITB;NOG;ELANE;CD74;Fzd4
interferon-gamma receptor activityIFNGR1;IFNGR2
protein bindingPDGFRA;SF3B3;HLX;PIP5K1B;NTSR1;BCL2;HLCS;NRIP2;CRADD

IFNGR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFNGR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IFNGR1.

STAT1; IFNG; c-fos promoter region; NFKB1; purL; fruB; Stat3

Gene Family

Cytokines

Research Area

Related articles

Ciftdogan, DY; Onay, H; et al. IFNG and IFNGR1 gene polymorphisms in children with nonresponse to the hepatitis B vaccine. FUTURE VIROLOGY 9:123-130(2014).
Lee, SH; Carrero, JA; et al. Identifying the Initiating Events of Anti-Listeria Responses Using Mice with Conditional Loss of IFN-gamma Receptor Subunit 1 (IFNGR1). JOURNAL OF IMMUNOLOGY 191:4223-4234(2013).
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