Recombinant Human IL10 Protein
Cat.No. : | IL10-93H |
Product Overview : | Recombinant Human Interleukin-10 is produced by our Mammalian expression system and the target gene encoding Ser19-Asn178 is expressed. |
- Specification
- Gene Information
- Related Products
Description : | Interleukin 10(IL10), also known as cytokine synthesis inhibitory factor (CSIF),is a secreted protein and belongs to the IL-10 family. IL-10 is secreted by many activated hematopoietic cell types as well as hepatic stellate cells, keratinocytes, and placental cytotrophoblasts . IL-10 is an anti-inflammatory TH2 cytokine that has a critical role in limiting the immune response to pathogens to prevent host damage. As IL-10 in produced in several T helper populations, it is proposed that it provides a feedback loop to limit the effector functions of macrophages and DCs on T cells. Once expressed, IL-10 signals through the IL-10 receptor (IL-10R) to activate STAT3. As IL-10 is a strong inhibitor of inflammation, it has become a viable biomarker for various diseases and conditions as well as a therapeutic molecule for certain conditions. In addition to elevated levels in parasitic infection, high expression levels of IL-10 are also found in retroviral infections inducing immunodeficiency. The immunosuppressive properties of IL-10 suggest a possible clinical use of IL-10 in suppressing rejections of grafts after organ transplantations. |
Source : | Human Cells |
Species : | Human |
Form : | Lyophilized from a 0.2 um filtered solution of 20mM PB,150mM NaCl, pH7.4. |
AA Sequence : | Ser19-Asn178 |
Endotoxin : | Less than 0.1 ng/ug (1 EU/ug). |
Purity : | >95% |
Storage : | Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 centigrade for 2-7 days. Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months. |
Quality Statement : | Purity: Greater than 95% as determined by reducing SDS-PAGE. |
Shipping : | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
Gene Name : | IL10 interleukin 10 [ Homo sapiens (human) ] |
Official Symbol : | IL10 |
Synonyms : | Interleukin-10; IL-10; Cytokine synthesis inhibitory factor; RP11-262N9.1; MGC126450; MGC126451; CSIF; TGIF; GVHDS; IL10A |
Gene ID : | 3586 |
mRNA Refseq : | NM_000572.3 |
Protein Refseq : | NP_000563.1 |
MIM : | 124092 |
UniProt ID : | P22301 |
Products Types
◆ Recombinant Protein | ||
IL10-2288C | Recombinant Chicken IL10 Protein, His-tagged | +Inquiry |
Il10-083M | Active Recombinant Mouse Il10 Protein | +Inquiry |
IL10-499H | Recombinant Human IL10 Protein | +Inquiry |
Il10-261I | Active Recombinant Mouse Il10 Protein | +Inquiry |
IL10-2697H | Recombinant Human IL10 protein(19-178 aa), N-MBP & C-His-tagged | +Inquiry |
◆ Lysates | ||
IL10-2079HCL | Recombinant Human IL10 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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