IL10
-
Official Full Name
interleukin 10
-
Background
factor involved in the inhibition of cytokine synthesis [RGD, Feb 2006] -
Synonyms
IL10; interleukin 10; IL10X; interleukin-10; CSIF; IL-10; cytokine synthesis inhibitory factor;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL10 Related Articles
- IL10 Related Gene Family
- IL10 Related Signal Pathway
IL10 involved in several pathways and played different roles in them. We selected most pathways IL10 participated on our site, such as African trypanosomiasis, Allograft Rejection, Amoebiasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
African trypanosomiasis | VCAM1;IL1B;THOP1;TLR9;IL18;IL10;IL12B;IL6;ICAM1 |
Allograft Rejection | IL12B;HLA-G;MICA;GZMB;Fasl;HLA-A;HLA-E;HLA-DQA2;H2-AB1 |
Amoebiasis | SERPINB2;PRKCG;RAB7A;FN1;CXCL1;COL4A4;ARG2;IL1R2;COL3A1 |
Asthma | HLA-DRB4;CD40LG;FCER1G;TNF;EPX;HLA-DMB;IL4;HLA-DRB3;H2-AB1 |
Autoimmune thyroid disease | CGA;CTLA4;IFN-a;IL10;OSTN |
Chagas disease (American trypanosomiasis) | SMAD3;MAP2K4;Fasl;CCL2;CFLAR;CD3E;TRAF6;PIK3R5;IL1B |
Cytokine-cytokine receptor interaction | IFNA5;IL8L1;EDA2R;IL2RA;IFNA3;VEGFC;IL17RA;CNTF;GM10591 |
IL10 has several biochemical functions, for example, cytokine activity, growth factor activity, interleukin-10 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL10 itself. We selected most functions IL10 had, and list some proteins which have the same functions with IL10. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
cytokine activity | BMP6;FAM3C;TNFB;BMP2B;IL29;SP100;GDF11;CMTM1;CXCL9 |
growth factor activity | CECR1;GRN;HDGFRP3;GDF7;LFT2;GDF11;BMP15;GPI;MSTN |
interleukin-10 receptor binding |
IL10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL10 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL10.
IL10RA; A2M
- Q&As
- Reviews
Q&As (10)
Ask a questionCutting-edge imaging techniques, alongside in vivo disease models, allow for precise assessment of therapeutic effects and tissue responses to IL-10-based treatments.
Advanced technologies, including single-cell RNA sequencing and flow cytometry, enable a granular analysis of IL-10's impact on diverse immune cell subpopulations.
Genotyping studies and genetic association analyses help correlate variations in IL-10 and its receptor with disease susceptibility across diverse populations.
Advanced immunomonitoring tools, including multiplex cytokine assays and immune cell phenotyping, provide comprehensive safety evaluations of IL-10 interventions in clinical trials.
In vitro models involve exposing immune cells to IL-10 and assessing changes in cytokine secretion and cell activation markers to uncover its anti-inflammatory mechanisms.
State-of-the-art techniques such as phosphoproteomics, mass spectrometry, and protein-protein interaction assays provide insights into the intricate signaling cascades activated by IL-10.
Dose-response studies in animal models coupled with outcome measures like cytokine profiles and immune cell phenotypes help determine the optimal IL-10 dosage and administration routes.
Experimental designs encompass co-stimulation experiments, coupled with functional assays and high-dimensional analysis, to elucidate synergistic effects involving IL-10 and other cytokines.
Techniques like RT-PCR, immunohistochemistry, and spatial transcriptomics are employed to characterize IL-10 receptor expression patterns in specific tissues and disease contexts.
CRISPR/Cas9 gene editing is used to create knockout or overexpression models, combined with functional assays, to decipher IL-10's regulatory roles in autoimmune disease pathways.
Customer Reviews (3)
Write a reviewEffective in anti-inflammatory assays. -
High purity levels. -
Stable under long-term storage. -
Ask a Question for All IL10 Products
Required fields are marked with *
My Review for All IL10 Products
Required fields are marked with *