IL10

  • Official Full Name

    interleukin 10

  • Background

    factor involved in the inhibition of cytokine synthesis [RGD, Feb 2006]
  • Synonyms

    IL10; interleukin 10; IL10X; interleukin-10; CSIF; IL-10; cytokine synthesis inhibitory factor;
    • Type:
    • Recombinant Proteins
    • GMP Proteins
    • Cell & Tissue Lysates
    • Transfected Stable Cell Lines
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Bovine
    • Cattle
    • Chicken
    • Cotton Rat
    • Cynomolgus
    • Dog
    • Equine
    • Feline
    • Goat
    • Horse
    • Human
    • Monkey
    • Mouse
    • Ovine
    • Pig
    • Porcine
    • Rabbit
    • Rat
    • Rhesus macaque
    • Rhesus Macaque
    • Rhesus monkey
    • Sheep
    • Zebrafish
    • Source :
    • CHO
    • E. coli
    • E.coli
    • HEK293
    • HEK293 cells
    • HEK293F
    • HEK293T
    • Human
    • Human Cell
    • Human cells
    • Insect Cell
    • Mammalian Cell
    • Nicotiana Benthamiana
    • Sf21 Insect Cell
    • Yeast
    • Tag :
    • C
    • terminal 10xHis
    • tagged
    • Fc
    • GST
    • His
    • His (Fc)
    • Avi
    • His(C
    • ter)
    • His|GST
    • His|Myc
    • His|T7
    • B2M
    • Myc
    • DDK
    • MYC
    • N/A
    • N
    • Strep II
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Bovine IL10-37B Recombinant Bovine IL-10 Yeast N/A
    Bovine IL10-5436B Recombinant Bovine IL10 protein, His-tagged Yeast His
    Cattle IL10-836C Recombinant Cattle IL10 protein, His & T7-tagged E.coli His/T7
    Cattle IL10-997C Recombinant Cattle IL10 Protein, His-tagged HEK293F N-His
    Chicken IL10-2288C Recombinant Chicken IL10 Protein, His-tagged HEK293F N-His
    Chicken IL10-999C Recombinant Chicken IL10 Protein, His&GST-tagged E.coli N-His&GST
    Chicken IL10-1232C Recombinant Chicken IL10 Mammalian Cell His
    Chicken IL10-246C Active Recombinant Chicken Interleukin 10 Yeast N/A
    Cotton Rat Il10-382C Active Recombinant Cotton Rat Il10 E.coli N/A
    Cynomolgus IL10-0292C Recombinant Cynomolgus IL10 protein, His-tagged HEK293 His
    Dog IL10-837D Recombinant Dog IL10 protein, His & GST-tagged E.coli His/GST
    Dog IL10-492D Recombinant Dog IL10 protein, His-tagged HEK293F His
    Equine IL10-103E Recombinant Equine IL-10 Yeast N/A
    Feline IL10-215F Active Recombinant Feline IL10 E.coli N/A
    Goat IL10-994G Recombinant Goat IL10 Protein, His-tagged E.coli N-His
    Horse IL10-838H Recombinant Horse IL10 protein, His & GST-tagged E.coli His/GST
    Human IL10-839H Recombinant Human IL10 protein, His & T7-tagged E.coli His/T7
    Human IL10-4326HG GMP Recombinant Human IL10 protein HEK293
    Human IL10-2033H Recombinant Human IL10 Protein, His-tagged HEK293 His
    Human IL10-301H Recombinant Human IL10 protein, His-Avi-tagged HEK293 His-Avi
    Human IL10-2486H Recombinant Human IL10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human IL10-060H Recombinant Human IL10 Protein E. coli
    Human IL10-28293TH Recombinant Human IL10 N/A
    Human IL10-02H Active Recombinant Human IL10 Protein, His-Tagged Insect Cell His
    Human IL10-29629TH Recombinant Human IL10 protein E.coli N/A
    Human IL10-46H Recombinant Human IL10 Protein E.coli
    Human IL10-12H Active Recombinant Human IL10 E.coli N/A
    Human IL10-28294TH Recombinant Human IL10 E.coli N/A
    Human IL10-14140H Recombinant Human IL10, GST-tagged E.coli GST
    Human IL10-372H Recombinant Human IL10 protein, His-tagged HEK293 His
    Human IL10-507H Active Recombinant Human IL10 HEK293 N/A
    Human IL10-326H Recombinant Human IL10, Fc-tagged CHO Fc
    Human IL10-588H Active Recombinant Human IL10, HIgG1 Fc-tagged, mutant CHO Fc
    Human IL10-28928TH Recombinant Human IL10, His-tagged E.coli His
    Human IL10-2079HCL Recombinant Human IL10 cell lysate Human Cell N/A
    Human IL10-566H Active Recombinant Human IL10, HIgG1 Fc-tagged CHO Fc
    Human IL10-267H Recombinant Human IL10, StrepII-tagged Human Cell Strep II
    Human IL10-599H Active Recombinant Human IL10, MIgG2a Fc-tagged CHO Fc
    Human IL10-1555H Recombinant human IL10, Active Nicotiana Benthamiana N/A
    Human IL10-217H Recombinant Human Interleukin 10 Sf21 Insect Cell N/A
    Human IL10-110H Recombinant Human Interleukin 10 HEK293 N/A
    Human IL10-40H Recombinant Human Interleukin 10 CHO N/A
    Human IL10-364H Recombinant Human Interleukin 10, His-tagged E.coli His
    Human IL10-4325HG GMP Recombinant Human IL10 protein E.coli N/A
    Human IL10-22HG Recombinant Human IL10 Protein (Ser19-Asn178), GMP Grade, Animal-Free E.coli
    Human IL10-478H Active Recombinant Human Interleukin 10 E.coli N/A
    Human IL10-530H Recombinant Human Interleukin 10, His-tagged Human His
    Human IL10-04HG Recombinant Human IL10 Protein (Ser19-Asn178), GMP Grade, Animal-Free E.coli
    Human IL10-16H Recombinant Human IL10 protein E.coli N/A
    Human IL10-626H Recombinant Human Interleukin 10 HEK293 N/A
    Human IL10-3025H Recombinant Human Interleukin-10, T7-tagged E.coli T7
    Human IL10-0021H Recombinant Human IL10 Protein HEK293 cells
    Human IL10-13H Recombinant Human IL10 Protein, Pre-aliquoted Insect Cell
    Human IL10-127H Recombinant Human IL10 Protein E.coli
    Human IL10-499H Recombinant Human IL10 Protein
    Human IL10-93H Recombinant Human IL10 Protein Human Cell
    Human IL10-24H Recombinant Human IL10 Protein, Animal Free Human cells
    Human IL10-262I Recombinant Human IL10 Protein CHO
    Human IL10-135H Human Interleukin-10 (rDNA derived) Reference standard N/A
    Human IL10-2627H Recombinant Human IL10 protein, His-tagged HEK293 His
    Human IL10-134H Recombinant Active Human IL10 Protein, His-tagged(C-ter) E.coli His(C-ter)
    Monkey IL10-4400M Recombinant Monkey IL10 Protein Yeast N/A
    Mouse Il10-2566M Recombinant Mouse Il10 protein, His-tagged E.coli His
    Mouse Il10-135M Recombinant Active Mouse IL10 Protein, His-tagged(C-ter) E.coli His(C-ter)
    Mouse Il10-214M Active Recombinant Mouse Il10 protein E.coli N/A
    Mouse Il10-01M Active Recombinant Mouse Il10 Protein, His-Tagged E.coli His
    Mouse Il10-3975M Recombinant Mouse Il10 protein, His-tagged E.coli His
    Mouse Il10-261I Recombinant Mouse Il10 Protein CHO
    Mouse IL10-500M Recombinant Mouse IL10 Protein
    Mouse IL10-128M Recombinant Mouse IL10 Protein E.coli
    Mouse Il10-328M Recombinant Mouse Il10, Fc-tagged CHO Fc
    Mouse IL10-115M Recombinant Mouse IL10 Protein E.coli
    Mouse IL10-001M Active Recombinant Mouse IL10, MIgG2a Fc-tagged CHO Fc
    Mouse Il10-029I Recombinant Mouse Il10 Protein (161 aa) E.coli
    Mouse IL10-002M Active Recombinant Mouse IL10, MIgG2a Fc-tagged, mutant CHO Fc
    Mouse Il10-995M Recombinant Mouse Il10 Protein, His-tagged HEK293F N-His
    Mouse Il10-17M Recombinant Mouse Il10 protein E.coli N/A
    Mouse Il10-642M Recombinant Mouse Il10 protein E.coli N/A
    Mouse Il10-082M Recombinant Mouse Il10 Protein E.coli
    Mouse Il10-501M Recombinant Mouse Il10 protein, His-tagged HEK293 His
    Mouse Il10-083M Recombinant Mouse Il10 Protein E.coli
    Mouse Il10-084M Recombinant Mouse Il10 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Il10-840M Recombinant Mouse Il10 protein, His & T7-tagged E.coli His/T7
    Ovine IL10-33O Recombinant Ovine IL10 Protein Yeast
    Pig IL10-136P Recombinant Active Pig IL10 Protein, His-tagged(C-ter) E.coli His(C-ter)
    Pig IL10-996P Recombinant Pig IL10 Protein, His&GST-tagged E.coli N-His&GST
    Pig IL10-79P Recombinant Porcine Interleukin 10 E.coli N/A
    Pig IL10-569P Recombinant Pig IL10 protein E.coli N/A
    Pig Il10-17S Recombinant Swine Il10 Yeast N/A
    Porcine IL10-01P Active GMP Recombinant Porcine IL10 Protein, His-Tagged E.coli His
    Rabbit IL10-1761R Recombinant Rabbit IL10 protein, His-tagged E.coli His
    Rabbit IL10-513R Recombinant Rabbit IL10 protein, His-tagged HEK293F His
    Rat IL10-001R Active Recombinant Rat IL10, HIgG1 Fc-tagged CHO Fc
    Rat Il10-371I Recombinant Rat Il10 Protein (161 aa) E.coli
    Rat Il10-484R Recombinant Rat Il10 protein, His-tagged HEK293F His
    Rat IL10-129R Recombinant Rat IL10 Protein E.coli
    Rat Il10-006I Recombinant Rat Il10 Protein (160 aa) E.coli
    Rat IL10-2678R Recombinant Rat IL10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat Il10-260I Recombinant Rat Il10 Protein CHO
    Rat Il10-554R Recombinant Rat Il10 protein E.coli N/A
    Rat IL10-2678R-B Recombinant Rat IL10 Protein Pre-coupled Magnetic Beads HEK293
    Rat Il10-1657R Recombinant Rat Il10 Protein, His-tagged E.coli N-His
    Rat Il10-18R Recombinant Rat Il10 protein E.coli N/A
    Rat Il10-841R Recombinant Rat Il10 protein, His & T7-tagged E.coli His/T7
    Rat IL10-3023R Recombinant Rat IL10 Protein Mammalian Cell His
    Rhesus macaque IL10-2232R Recombinant Rhesus macaque IL10 protein, C-terminal 10xHis-tagged-tagged Insect Cell C-terminal 10xHis-tagged
    Rhesus macaque IL10-22R Recombinant Rhesus macaque IL10 Protein, His-tagged Yeast His
    Rhesus Macaque IL10-2049R-B Recombinant Rhesus Macaque IL10 Protein Pre-coupled Magnetic Beads HEK293
    Rhesus macaque IL10-1297R Recombinant Rhesus macaque IL10 protein, Fc-tagged HEK293 Fc
    Rhesus macaque IL10-3090R Recombinant Rhesus macaque IL10 protein, His-B2M-tagged E.coli His-B2M
    Rhesus macaque IL10-23R Recombinant Rhesus macaque IL10 Protein, His/Myc-tagged Insect Cell His/Myc
    Rhesus Macaque IL10-2049R Recombinant Rhesus Macaque IL10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque IL10-2228R Recombinant Rhesus monkey IL10 Protein, His-tagged Mammalian Cell His
    Rhesus monkey IL10-21R Recombinant Rhesus monkey IL10 protein, His/GST-tagged E.coli His/GST
    Rhesus monkey IL10-20R Recombinant Rhesus monkey IL10 protein, His-tagged E.coli His
    Sheep IL10-5769S Recombinant Sheep IL10 protein, His-tagged Yeast His
    Zebrafish il10-998Z Recombinant Zebrafish il10 Protein, His-tagged E.coli N-His
    Zebrafish IL10-2921Z Recombinant Zebrafish IL10 Mammalian Cell His
    Zebrafish il10-15Z Recombinant Zebrafish il10 protein Yeast N/A
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL10 Related Articles
    • IL10 Related Gene Family
    • IL10 Related Signal Pathway

    IL10 involved in several pathways and played different roles in them. We selected most pathways IL10 participated on our site, such as African trypanosomiasis, Allograft Rejection, Amoebiasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    African trypanosomiasisVCAM1;IL1B;THOP1;TLR9;IL18;IL10;IL12B;IL6;ICAM1
    Allograft RejectionIL12B;HLA-G;MICA;GZMB;Fasl;HLA-A;HLA-E;HLA-DQA2;H2-AB1
    AmoebiasisSERPINB2;PRKCG;RAB7A;FN1;CXCL1;COL4A4;ARG2;IL1R2;COL3A1
    AsthmaHLA-DRB4;CD40LG;FCER1G;TNF;EPX;HLA-DMB;IL4;HLA-DRB3;H2-AB1
    Autoimmune thyroid diseaseCGA;CTLA4;IFN-a;IL10;OSTN
    Chagas disease (American trypanosomiasis)SMAD3;MAP2K4;Fasl;CCL2;CFLAR;CD3E;TRAF6;PIK3R5;IL1B
    Cytokine-cytokine receptor interactionIFNA5;IL8L1;EDA2R;IL2RA;IFNA3;VEGFC;IL17RA;CNTF;GM10591

    IL10 has several biochemical functions, for example, cytokine activity, growth factor activity, interleukin-10 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL10 itself. We selected most functions IL10 had, and list some proteins which have the same functions with IL10. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activityBMP6;FAM3C;TNFB;BMP2B;IL29;SP100;GDF11;CMTM1;CXCL9
    growth factor activityCECR1;GRN;HDGFRP3;GDF7;LFT2;GDF11;BMP15;GPI;MSTN
    interleukin-10 receptor binding

    IL10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL10 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL10.

    IL10RA; A2M

    Markwick, LJL; Riva, A; et al. Blockade of PD1 and TIM3 Restores Innate and Adaptive Immunity in Patients With Acute Alcoholic Hepatitis. GASTROENTEROLOGY 148:590-+(2015).
    Shibahara, I; Saito, R; et al. OX40 ligand expressed in glioblastoma modulates adaptive immunity depending on the microenvironment: a clue for successful immunotherapy. MOLECULAR CANCER 14:-(2015).
    • Q&As
    • Reviews

    Q&As (10)

    Ask a question
    What state-of-the-art experimental strategies, including advanced imaging techniques, are implemented to meticulously assess the in vivo efficacy of IL-10-based therapies across a spectrum of inflammatory disorders? 02/12/2022

    Cutting-edge imaging techniques, alongside in vivo disease models, allow for precise assessment of therapeutic effects and tissue responses to IL-10-based treatments.

    How are advanced methods like single-cell RNA sequencing and flow cytometry harnessed to investigate the immunomodulatory impact of IL-10 across distinct immune cell subtypes? 02/10/2022

    Advanced technologies, including single-cell RNA sequencing and flow cytometry, enable a granular analysis of IL-10's impact on diverse immune cell subpopulations.

    Could you elaborate on the intricate experimental methodologies applied to unravel the influence of genetic polymorphisms within IL-10 and its receptor on disease susceptibility? 10/26/2021

    Genotyping studies and genetic association analyses help correlate variations in IL-10 and its receptor with disease susceptibility across diverse populations.

    How do researchers leverage advanced immunomonitoring tools to comprehensively evaluate the safety profiles of IL-10-based interventions in various clinical trial phases? 05/25/2021

    Advanced immunomonitoring tools, including multiplex cytokine assays and immune cell phenotyping, provide comprehensive safety evaluations of IL-10 interventions in clinical trials.

    How do researchers employ in vitro models to elucidate the mechanisms underlying IL-10's anti-inflammatory effects on immune cells? 12/03/2020

    In vitro models involve exposing immune cells to IL-10 and assessing changes in cytokine secretion and cell activation markers to uncover its anti-inflammatory mechanisms.

    What sophisticated experimental techniques are utilized to dissect the intricate signaling pathways downstream of IL-10 activation? 08/26/2020

    State-of-the-art techniques such as phosphoproteomics, mass spectrometry, and protein-protein interaction assays provide insights into the intricate signaling cascades activated by IL-10.

    Could you explain the multifaceted experimental strategies employed to determine the optimal dosage and administration routes for IL-10 in diverse animal models? 03/24/2019

    Dose-response studies in animal models coupled with outcome measures like cytokine profiles and immune cell phenotypes help determine the optimal IL-10 dosage and administration routes.

    What innovative experimental designs are employed to explore potential synergies between IL-10 and other cytokines, unraveling complex interplay in immune regulation? 11/23/2018

    Experimental designs encompass co-stimulation experiments, coupled with functional assays and high-dimensional analysis, to elucidate synergistic effects involving IL-10 and other cytokines.

    Can you elaborate on the comprehensive approaches scientists use to assess the tissue-specific expression patterns of IL-10 receptors in both normal and pathological conditions? 11/05/2018

    Techniques like RT-PCR, immunohistochemistry, and spatial transcriptomics are employed to characterize IL-10 receptor expression patterns in specific tissues and disease contexts.

    How are cutting-edge techniques such as CRISPR/Cas9 gene editing utilized to dissect the regulatory roles of IL-10 in complex autoimmune disease models? 02/22/2018

    CRISPR/Cas9 gene editing is used to create knockout or overexpression models, combined with functional assays, to decipher IL-10's regulatory roles in autoimmune disease pathways.

    Customer Reviews (3)

    Write a review
    Reviews
    09/27/2022

      Effective in anti-inflammatory assays. -

      01/09/2019

        High purity levels. -

        04/15/2017

          Stable under long-term storage. -

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