Recombinant Human IL17A, StrepII-tagged

Cat.No. : IL17A-288H
Product Overview : Purified, full-length human recombinant IL17A protein (amino acids 24-155, 132 a.a.) with StrepII tag, produced in human cells. Predicted molecular weight: 30.2 kDa. (Accession NP_002181.1; UniProt Q16552)
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Description : IL17A is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Source : Human Cells
Species : Human
Tag : StrepII
Form : Lyophilized from sterile 0.2μm filtered solution in 0.3X PBS with 10% Trehalose (carrier-free)
Protein length : 24-155, 132 a.a.
AA Sequence : GITIPRNPGCPNSEDKNFPRTVMVN LNIHNRNTNTNPKRSSDYYNRSTSP WNLHRNEDPERYPSVIWEAKCRHLG CINADGNVDYHMNSVPIQQEILVLR REPPHCPNSFRLEKILVSVGCTCVT PIVHHVA
Endotoxin : <0.1 eu per μg protein by lal
Purity : ~50% by SDS-PAGE
Storage : 12 months at -20°C as supplied; 1 month at 4°C after reconstitution. Avoid freeze/thaw cycles.
Reconstitution : Centrifuge the vial prior to opening. Reconstitute in PBS to a concentration of 0.1 mg/ml
Gene Name : IL17A interleukin 17A [ Homo sapiens ]
Official Symbol : IL17A
Synonyms : IL17A; interleukin 17A; CTLA8, IL17, interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8); interleukin-17A; cytotoxic T lymphocyte associated protein 8; IL 17; IL 17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; cytotoxic T-lymphocyte-associated serine esterase 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); IL17; CTLA8; IL-17; IL-17A;
Gene ID : 3605
mRNA Refseq : NM_002190
Protein Refseq : NP_002181
MIM : 603149
UniProt ID : Q16552
Chromosome Location : 6p12
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; IL23-mediated signaling events, organism-specific biosystem; IL27-mediated signaling events, organism-specific biosystem; Rheumatoid arthritis, organism-specific biosystem; Rheumatoid arthritis, conserved biosystem;
Function : cytokine activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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12/16/2018

    Good for receptor studies.

    03/05/2018

      Effective in Th17 differentiation.

      03/08/2017

        High bioactivity in various tissue types.

        Q&As (10)

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        Could you explain the role of IL17A in autoimmune disease progression using animal models? 05/22/2022

        Animal models, such as experimental autoimmune encephalomyelitis, explore IL17A's role in autoimmunity.

        Can you detail the protocols for inducing IL17A expression in T cells in vitro? 01/02/2021

        Inducing IL17A expression in T cells involves culturing them with specific cytokines.

        What strategies elucidate IL17A's impact on tissue-specific inflammation in human samples? 02/17/2020

        Studying IL17A's influence on tissue-specific inflammation in humans involves analyzing patient samples.

        Can you elaborate on the use of neutralizing antibodies in blocking IL17A's effects? 06/12/2019

        Neutralizing antibodies block IL17A's effects in cell cultures or animal models.

        How does one perform a multiplex cytokine assay to quantify IL17A along with other cytokines? 12/13/2018

        Multiplex cytokine assays use fluorescent beads to measure IL17A and other cytokines simultaneously.

        How is the IL17A receptor (IL17RA) signaling pathway activated and studied? 11/23/2018

        IL17RA signaling is triggered by IL17A binding and is studied through downstream phosphorylation assays.

        What are the methods to investigate the impact of IL17A on epithelial barrier integrity? 08/09/2018

        Methods like transepithelial electrical resistance (TEER) assay evaluate IL17A's effect on barrier function.

        How is IL17A's contribution to neutrophil recruitment assessed in inflammatory models? 06/25/2018

        Inflammatory models, like airway inflammation assays, examine IL17A's impact on neutrophil recruitment.

        What techniques are used to analyze IL17A-producing cell populations within a tissue? 06/22/2018

        Flow cytometry or intracellular staining help identify IL17A-producing cell subsets within tissues.

        What experimental design is employed to understand IL17A's involvement in cancer development? 03/23/2018

        Experimental designs combine cancer cell lines with IL17A stimulation to investigate its pro-tumor effects.

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