Recombinant Mouse Il17a
Cat.No. : | Il17a-12M |
Product Overview : | Mouse IL-17A was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified. |
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Description : | IL-17A is a member of the IL-17 family, which is comprised of 6 members [IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F]. IL-17 family members are involved in numerous immune regulatory functions, including inducing and mediating proinflammatory responses and allergic responses. IL-17 induces the production of many other cytokines (IL-6, G-CSF, GM-CSF, IL-1beta, TGF-beta, and TNF-alpha), chemokines, including IL-8 (CXCL8), GRO-alpha (CXCL1) and MCP-1 (CCL2) and prostaglandins from many cell types (fibroblasts, endothelial cells, epithelial cells, keratinocytes and macrophages). |
Source : | Yeast |
Species : | Mouse |
Form : | Lyophilized. Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein. |
Molecular Mass : | Mouse IL-17A has a predicted molecular weight of 15.0 kDa. |
AA Sequence : | AAIIPQSSAC PNTEAKDFLQ NVKVNLKVFN SLGAKVSSRR PSDYLNRSTS PWTLHRNEDP DRYPSVIWEA QCRHQRCVNA EGKLDHHMNS VLIQQEILVL KREPESCPFT FRVEKMLVGV GCTCVASIVR QAA (133) |
Purity : | >95% as visualized by SDS-PAGE analysis. |
Applications : | The Mouse IL-17A protein can be used in cell culture, as a IL-17A ELISA Standard, and as a Western Blot Control. |
Storage : | Stable for up to twelve months from date of receipt at -20?C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20?C. Avoid repeated freeze/thaw cycles. |
Tag : | Non |
Gene Name : | Il17a interleukin 17A [ Mus musculus (house mouse) ] |
Official Symbol : | Il17a |
Synonyms : | Il17a; Il17; Ctla8; IL-17; Ctla-8; IL-17A; interleukin 17A; interleukin-17A; cytotoxic T-lymphocyte-associated antigen 8 |
Gene ID : | 16171 |
mRNA Refseq : | NM_010552 |
Protein Refseq : | NP_034682 |
UniProt ID : | Q62386 |
Chromosome Location : | 1; 1 A |
Pathway : | Cytokine-cytokine receptor interaction; Inflammatory bowel disease (IBD); Rheumatoid arthritis |
Function : | cytokine activity |
Products Types
◆ Recombinant Protein | ||
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IL17A-48H | Recombinant Human IL17A Protein | +Inquiry |
IL17A-5633H | Recombinant Human IL17A protein, His-tagged | +Inquiry |
IL17A-440R | Active Recombinant Rabbit IL17 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
IL17A-001HCL | Recombinant Human IL17A cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewGood for receptor studies.
Effective in Th17 differentiation.
High bioactivity in various tissue types.
Q&As (10)
Ask a questionAnimal models, such as experimental autoimmune encephalomyelitis, explore IL17A's role in autoimmunity.
Inducing IL17A expression in T cells involves culturing them with specific cytokines.
Studying IL17A's influence on tissue-specific inflammation in humans involves analyzing patient samples.
Neutralizing antibodies block IL17A's effects in cell cultures or animal models.
Multiplex cytokine assays use fluorescent beads to measure IL17A and other cytokines simultaneously.
IL17RA signaling is triggered by IL17A binding and is studied through downstream phosphorylation assays.
Methods like transepithelial electrical resistance (TEER) assay evaluate IL17A's effect on barrier function.
Inflammatory models, like airway inflammation assays, examine IL17A's impact on neutrophil recruitment.
Flow cytometry or intracellular staining help identify IL17A-producing cell subsets within tissues.
Experimental designs combine cancer cell lines with IL17A stimulation to investigate its pro-tumor effects.
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