Recombinant Mouse Il17a

Cat.No. : Il17a-12M
Product Overview : Mouse IL-17A was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
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Description : IL-17A is a member of the IL-17 family, which is comprised of 6 members [IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F]. IL-17 family members are involved in numerous immune regulatory functions, including inducing and mediating proinflammatory responses and allergic responses. IL-17 induces the production of many other cytokines (IL-6, G-CSF, GM-CSF, IL-1beta, TGF-beta, and TNF-alpha), chemokines, including IL-8 (CXCL8), GRO-alpha (CXCL1) and MCP-1 (CCL2) and prostaglandins from many cell types (fibroblasts, endothelial cells, epithelial cells, keratinocytes and macrophages).
Source : Yeast
Species : Mouse
Form : Lyophilized. Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.
Molecular Mass : Mouse IL-17A has a predicted molecular weight of 15.0 kDa.
AA Sequence : AAIIPQSSAC PNTEAKDFLQ NVKVNLKVFN SLGAKVSSRR PSDYLNRSTS PWTLHRNEDP DRYPSVIWEA QCRHQRCVNA EGKLDHHMNS VLIQQEILVL KREPESCPFT FRVEKMLVGV GCTCVASIVR QAA (133)
Purity : >95% as visualized by SDS-PAGE analysis.
Applications : The Mouse IL-17A protein can be used in cell culture, as a IL-17A ELISA Standard, and as a Western Blot Control.
Storage : Stable for up to twelve months from date of receipt at -20?C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20?C. Avoid repeated freeze/thaw cycles.
Tag : Non
Gene Name : Il17a interleukin 17A [ Mus musculus (house mouse) ]
Official Symbol : Il17a
Synonyms : Il17a; Il17; Ctla8; IL-17; Ctla-8; IL-17A; interleukin 17A; interleukin-17A; cytotoxic T-lymphocyte-associated antigen 8
Gene ID : 16171
mRNA Refseq : NM_010552
Protein Refseq : NP_034682
UniProt ID : Q62386
Chromosome Location : 1; 1 A
Pathway : Cytokine-cytokine receptor interaction; Inflammatory bowel disease (IBD); Rheumatoid arthritis
Function : cytokine activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
12/16/2018

    Good for receptor studies.

    03/05/2018

      Effective in Th17 differentiation.

      03/08/2017

        High bioactivity in various tissue types.

        Q&As (10)

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        Could you explain the role of IL17A in autoimmune disease progression using animal models? 05/22/2022

        Animal models, such as experimental autoimmune encephalomyelitis, explore IL17A's role in autoimmunity.

        Can you detail the protocols for inducing IL17A expression in T cells in vitro? 01/02/2021

        Inducing IL17A expression in T cells involves culturing them with specific cytokines.

        What strategies elucidate IL17A's impact on tissue-specific inflammation in human samples? 02/17/2020

        Studying IL17A's influence on tissue-specific inflammation in humans involves analyzing patient samples.

        Can you elaborate on the use of neutralizing antibodies in blocking IL17A's effects? 06/12/2019

        Neutralizing antibodies block IL17A's effects in cell cultures or animal models.

        How does one perform a multiplex cytokine assay to quantify IL17A along with other cytokines? 12/13/2018

        Multiplex cytokine assays use fluorescent beads to measure IL17A and other cytokines simultaneously.

        How is the IL17A receptor (IL17RA) signaling pathway activated and studied? 11/23/2018

        IL17RA signaling is triggered by IL17A binding and is studied through downstream phosphorylation assays.

        What are the methods to investigate the impact of IL17A on epithelial barrier integrity? 08/09/2018

        Methods like transepithelial electrical resistance (TEER) assay evaluate IL17A's effect on barrier function.

        How is IL17A's contribution to neutrophil recruitment assessed in inflammatory models? 06/25/2018

        Inflammatory models, like airway inflammation assays, examine IL17A's impact on neutrophil recruitment.

        What techniques are used to analyze IL17A-producing cell populations within a tissue? 06/22/2018

        Flow cytometry or intracellular staining help identify IL17A-producing cell subsets within tissues.

        What experimental design is employed to understand IL17A's involvement in cancer development? 03/23/2018

        Experimental designs combine cancer cell lines with IL17A stimulation to investigate its pro-tumor effects.

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