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Recombinant Human IL17RB, hIgG-His-tagged

Cat.No. : IL17RB-41H
Product Overview : Recombinant human IL17RB, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
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Description : IL17RB, also known as Interleukin-17 receptor B, is a cytokine receptor. This receptor specifically binds to IL17B and IL17E (IL25), but does not bind to IL17(A) or IL17C. It has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. It was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.
Source : Insect cell
Species : Human
Tag : hIgG-His
Form : Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.
Molecular Mass : 57.2kDa (514aa), Reducing conditions 50-70KDa (SDS-PAGE under reducing conditions.)
AA Sequence : REPTVQCGSE TGPSPEWMLQ HDLIPGDLRD LRVEPVTTSV ATGDYSILMN VSWVLRADAS IRLLKATKIC VTGKSNFQSY SCVRCNYTEA FQTQTRPSGG KWTFSYIGFP VELNTVYFIG AHNIPNANMN EDGPSMSVNF TSPGCLDHIM KYKKKCVKAG SLWDPNITAC KKNEETVEVN FTTTPLGNRY MALIQHSTII GFSQVFEPHQ KKQTRASVVI PVTGDSEGAT VQLTPYFPTC GSDCIRHKGT VVLCPQTGVP FPLDNNKSKP GGWLPVEPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSRDELT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGKHH HHHH
Endotoxin : < 1.0 eu per 1 microgram of protein (determined by lal
Purity : >85% by SDS - PAGE
Storage : Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration : 0.25mg/ml (determined by Bradford assay)
Gene Name : IL17RB interleukin 17 receptor B [ Homo sapiens ]
Official Symbol : IL17RB
Synonyms : IL17RB; interleukin 17 receptor B; IL17BR, interleukin 17B receptor; interleukin-17 receptor B; CRL4; EVI27; IL17RH1; IL-17RB; IL-17Rh1; IL-17B receptor; IL-17 receptor B; cytokine receptor CRL4; IL-17 receptor homolog 1; cytokine receptor-like 4; interleukin 17B receptor; interleukin-17B receptor; interleukin 17 receptor homolog 1; IL17BR; MGC5245;
Gene ID : 55540
mRNA Refseq : NM_018725
Protein Refseq : NP_061195
MIM : 605458
UniProt ID : Q9NRM6
Chromosome Location : 3p21.1
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;
Function : cytokine receptor activity; receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Can you elaborate on the techniques employed to study the role of IL17RB in tissue-specific inflammation and immune cell recruitment? 11/17/2021

Animal models, flow cytometry, and tissue-specific knockout strategies uncover IL17RB's involvement in inflammation and cell recruitment.

How do researchers manipulate IL17RB expression and function in cellular and animal models to understand its contribution to autoimmune diseases? 07/10/2021

CRISPR/Cas9, siRNA, and gene editing techniques manipulate IL17RB to investigate its role in autoimmune disease pathogenesis.

Could you explain how patient samples and clinical data are utilized to investigate the correlation between IL17RB expression and disease severity in various inflammatory disorders? 01/06/2020

Biomarker analysis, patient stratification, and clinical correlation studies investigate IL17RB's association with disease severity.

What molecular and cellular assays are employed to explore the interaction between IL17RB and other immune receptors or cytokines? 09/15/2019

Co-receptor binding assays, protein-protein interaction studies, and functional rescue experiments reveal IL17RB's interaction partners.

What experimental strategies are used to dissect the involvement of IL17RB in tissue repair processes, such as wound healing and fibrosis? 05/23/2019

In vitro wound healing assays, fibroblast activation studies, and tissue regeneration models probe IL17RB's contribution to tissue repair.

What techniques are used to study the impact of IL17RB inhibition or activation on immune responses and inflammation in experimental settings? 07/29/2018

Blocking antibodies, receptor activation assays, and cytokine profiling reveal IL17RB's impact on immune responses.

How is the potential of IL17RB as a therapeutic target evaluated in preclinical studies, and what challenges exist in translating these findings into clinical applications? 12/31/2017

Animal models, therapeutic antibody studies, and safety assessments evaluate IL17RB-targeted therapies and clinical translation challenges.

How is the ligand binding affinity of IL17RB to different IL17 family members determined experimentally? 12/02/2017

Surface plasmon resonance, ELISA, and competitive binding assays determine IL17RB's affinity for various IL17 family members.

How do researchers investigate the role of IL17RB in cancer and tumor microenvironment modulation, and what experimental models are commonly used? 08/23/2017

Tumor xenograft models, immune cell infiltration assays, and gene expression analysis explore IL17RB's role in cancer biology.

What experimental methods are used to investigate the downstream signaling pathways activated by IL17RB, and how are these pathways integrated with other immune responses? 04/18/2017

Phosphorylation assays, gene expression profiling, and co-immunoprecipitation studies elucidate IL17RB-mediated signaling networks.

Customer Reviews (3)

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Reviews
10/07/2022

    High stability.

    06/23/2022

      Good for flow cytometry.

      05/20/2017

        Potent in anti-viral assays.

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