- Human(14)
Recombinant Human IL1F7
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Cat.No. : | IL1F7-318H Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant Human IL-1F7 (Lys27-Asp192) produced in E. coli is a single, non-glycosylated, polypeptide chain containing 167 amino acids and having a molecular mass of 18.6 kDa. |
Description : | Human interleukin family 1, member 7 (hIL-1F7 / FIL1-zeta) is a member of the interleukin 1 cytokine family. Five alternatively spliced transcript variants encoding distinct isoforms have been reported with distinct expression profiles. The longest IL-1F7 transcript, referred to as IL1F7b or IL1F7 isoform 1, encodes a 218 a.a. residues proprotein containing a 45 a.a. propeptide which is cleaved to generate mature protein. IL-1F7b binds to IL-18 Rα with low affinity but does not exert any IL-18 agonistic or antagonistic effects. IL-1F7b also binds interleukin 18 binding protein (IL-18BP), an inhibitory binding protein of interleukin 18 (IL-18), and subsequently forms a complex with IL-18 receptor beta subunit, and through which it inhibits the activity of IL-18. |
Biological Activity : | As measured by its binding ability in a functional ELISA, immobilized rHuIL-1F7 at 1 μg/ml (100 μl/well) can bind rhIL-18 R/Fc Chimera with a linear range of 0.015~1 μg/mL. |
Purity : | Greater than 95% as determined by (a) Analysis by RP-HPLC; (b) Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel. |
Amino-Acid Sequence : | The sequence of the first five N-terminal amino acids was determined and was found to be Met-Lys-Asn-Leu-Asn. |
Endotoxin : | Less than 0.1ng/µg (1 IEU/µg) determined by LAL test. |
Form : | The protein was lyophilized after extensive dialysis against 20mM Phosphate buffer, pH7.4. |
Reconstitution : | It is recommended to quick spin followed by reconstitution of rHuIL-1F7 in PBS to a concentration no less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
Storage : | Lyophilized rHuIL-1F5 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution rHuIL-1F7 should be stored at 4°C between 2-7 days and for future use below -18°C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles. |
Gene Name : | IL1F7 interleukin 1 family, member 7 (zeta) [ Homo sapiens ] |
Official Symbol : | IL1F7 |
Synonyms : | IL1F7; interleukin 1 family, member 7 (zeta); FIL1; FIL1Z; IL1H4; IL-1F7; IL-1H4; IL1RP1; IL-1RP1; FIL1(ZETA); interleukin-1 family member 7 ; FIL1 zeta; IL-1 zeta; IL-1X protein; OTTHUMP00000162032; OTTHUMP00000162033; OTTHUMP00000162034; OTTHUMP00000162035; OTTHUMP00000162036; interleukin-1 zeta; interleukin 1, zeta; interleukin-1 homolog 4; interleukin-1 superfamily z; interleukin 1 family member 7; interleukin-1-related protein; IL-1F7b (IL-1H4, IL-1H, IL-1RP1); IL1F7 (canonical product IL-1F7b); Interleukin-1 zeta; Interleukin-1 homolog 4; Interleukin-1-related protein; IL-1X |
Gene ID : | 27178 |
mRNA Refseq : | NM_014439 |
Protein Refseq : | NP_055254 |
MIM : | 605510 |
UniProt ID : | Q9NZH6 |
Chromosome Location : | 2q12-q14.1 |
Function : | cytokine activity; interleukin-1 receptor antagonist activity; interleukin-1 receptor binding; protein binding |
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IL10IL10RAIL10RBIL11IL11RAIl11ra1IL12IL12AIL12BIL12RB1IL13IL13RA1IL13RA2IL15IL15RAIL16IL17AIL17BIl17cIL17DIl17fIL17RAIL17RDIL18IL18BPIL18R1IL18RAPIl19Il1aIl1bIL1F10IL1R1Il1r2IL1RAPIL1RAPL1IL1RAPL2IL1RL1IL1RL2Il1rnIL2Il20IL20RAIL21IL21RIL22IL22BPIL22RA1IL22RA2IL23AIL24Il25IL27IL27RAIL28AIl28bIL29IL2RAIL2RBIl2rgIL3IL31IL32Il33Il34IL3RAIL4IL4RIl4raIl5IL5RAIl6IL6RIl6raIL6STIl7IL7RIL8IL9IL36AIl12rb2IL17RBIL23RIL26IL31RAIL36BIL36GIL36RNIL37IL9RIL17RCIL17REIL28RAIL4I1IL20RBIL17RELIl11ra2IL27bIL7RAIl23a&Il12b
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