Recombinant Human IL37 protein, His-tagged

• Cat.No.: IL37-159H
• Product Overview: Recombinant Human IL37 (Val46-Asp218) protein was fused to His-tag at N-terminus and expressed in E.coli.

Specification

• Description: Interleukin-1 family member 7 (IL1F7b) ,a member of the IL-1 family, is aslo known as interleukin-37, interleukin-1 homolog 4 (IL-1H4), interleukin-1 zeta (IL-1 zeta) and interleukin-1-related protein, which can interact with SMAD3 and bind to IL18R1, but not to IL1R1, with lower affinity than IL18. IL1F7b is a suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Therefore,IL1F7b can suppress, or reduce, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spare anti-inflammatory cytokines. Furthermore,IL1F7b can also inhibit dendritic cell activation.
• Source: E.coli
• Species: Human
• Tag: His
• Predicted N Terminal: Val46
• Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose.
• Molecular Mass: The protein has a calculated MW of 20.3 kDa. The protein migrates as 20.3 kDa under reducing (R) condition (SDS-PAGE).
• Protein length: Val46-Asp218
• Endotoxin: Less than 1.0 EU per μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
  Please avoid repeated freeze-thaw cycles.
  This product is stable after storage at:
  -20 to -70 centigrade for 12 months in lyophilized state;
  -70 centigrade for 3 months under sterile conditions after reconstitution.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: IL37
• Official Symbol: IL37
• Synonyms: FIL1; FIL1Z; IL-1H; IL-37; IL1F7; IL1H4; IL-1F7; IL-1H4; IL1RP1; IL-1RP1; FIL1(ZETA)
• Gene ID: 27178
• mRNA Refseq: NM_014439.3
• Protein Refseq: NP_055254.2
• MIM: 605510
• UniProt ID: Q9NZH6

Reviews

01/16/2021

IL37 has a long half-life and is able to maintain stability and reliability during experiments.

02/28/2020

When using IL37 protein for experiments, it can meet specific experimental requirements and research purposes.

03/15/2019

IL37 products have a complete range of specifications and are suitable for experimental designs of different sizes and needs.

Q&As

Can IL37 be used in children?

The safety and efficacy of recombinant IL37 in children have not been established and need to be validated in further studies.

What is the action mechanism of IL37?

The IL37 works by inhibiting the release of inflammatory mediators and regulating immune cell levels, thereby reducing the inflammatory response.

How long is the course of IL37?

The length of treatment for IL37 varies depending on the severity of the disease and the patient's response, and generally requires long-term treatment.

Can IL37 be used to prevent inflammatory diseases?

At present, there is not enough evidence to show that IL37 can be used to prevent inflammatory diseases, and further studies are needed to verify it.

Is IL37 suitable for the treatment of allergic diseases?

IL37 has anti-inflammatory and immunomodulatory effects, and may have a certain effect on allergic diseases, but further studies are needed to verify it.

Can IL37 be taken orally?

IL37 is currently mainly administered by injection, and oral administration studies are still under way.