IL37
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Official Full Name
interleukin 37
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Background
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. -
Synonyms
interleukin 1 family, member 7 (zeta); Interleukin-1-related protein; FIL1Z; FIL1 zeta; IL-1 zeta; IL-1H4; IL-1RP1; IL-1X protein; IL1H4; IL1RP1; interleukin 1 family member 7; FIL1; interleukin 1, zeta; FIL1(ZETA); interleukin-1 family member 7; Interleukin-1 homolog 4; interleukin-1 superfamily z; Interleukin-1 zeta; IL-1X; IL-37; IL1F7; IL-1F7; interleukin-23; OTTHUMP00000162032; OTTHUMP00000162033; OTTHUMP00000162034; OTTHUMP00000162035; OTTHUMP00000162036; IL-1F7b (IL-1H4, IL-1H, IL-1RP1); IL1F7 (canonical product IL-1F7b); interleukin 37; IL37; IL-1H;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL37 Related Articles
- IL37 Related Research Area
IL37 involved in several pathways and played different roles in them. We selected most pathways IL37 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IL37 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
IL37 has several biochemical functions, for example, cytokine activity, interleukin-1 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL37 itself. We selected most functions IL37 had, and list some proteins which have the same functions with IL37. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | CMTM6;CCL38A.4;GDF7;BMP7;WNT7A;SPP1;TNFSF15;GM13285;IL17C |
| interleukin-1 receptor binding | IL36B;IL1RAP;IL1RN;TRIP6;IL36G;IL36RN;IL37;IL1B;IL1F10 |
IL37 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL37 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL37.
SMAD3
- Q&As
- Reviews
Q&As (6)
Ask a questionThe safety and efficacy of recombinant IL37 in children have not been established and need to be validated in further studies.
The IL37 works by inhibiting the release of inflammatory mediators and regulating immune cell levels, thereby reducing the inflammatory response.
The length of treatment for IL37 varies depending on the severity of the disease and the patient's response, and generally requires long-term treatment.
At present, there is not enough evidence to show that IL37 can be used to prevent inflammatory diseases, and further studies are needed to verify it.
IL37 has anti-inflammatory and immunomodulatory effects, and may have a certain effect on allergic diseases, but further studies are needed to verify it.
IL37 is currently mainly administered by injection, and oral administration studies are still under way.
Customer Reviews (3)
Write a reviewIL-37 has low toxicity and can be used safely in both in vivo and in vitro applications. -
This is involved in regulating the balance of the immune response and can inhibit excessive immune activity, thereby maintaining the stability of the immune system. -
It can transmit signals by binding to its receptors and exert anti-inflammatory and immunomodulatory biological activity in a variety of cell types and tissues. -
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