IL37
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Official Full Name
interleukin 37 -
Overview
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. -
Synonyms
interleukin 1 family, member 7 (zeta);Interleukin-1-related protein;FIL1Z;FIL1 zeta;IL-1 zeta;IL-1H4;IL-1RP1;IL-1X protein;IL1H4;IL1RP1;interleukin 1 family member 7;FIL1;interleukin 1, zeta;FIL1(ZETA);interleukin-1 family member 7;Interleukin-1 homolog 4;interleukin-1 superfamily z;Interleukin-1 zeta;IL-1X;IL-37;IL1F7;IL-1F7;interleukin-23;OTTHUMP00000162032;OTTHUMP00000162033;OTTHUMP00000162034;OTTHUMP00000162035;OTTHUMP00000162036;IL-1F7b (IL-1H4, IL-1H, IL-1RP1);IL1F7 (canonical product IL-1F7b);interleukin 37;IL37;IL-1H
Recombinant Proteins
- Human
- E.coli
- HEK293
- Human Cells
- Mammalian Cells
- GST
- His
- Non
- Avi
- Fc
- Flag
Involved Pathway
IL37 involved in several pathways and played different roles in them. We selected most pathways IL37 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IL37 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
IL37 has several biochemical functions, for example, cytokine activity,interleukin-1 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL37 itself. We selected most functions IL37 had, and list some proteins which have the same functions with IL37. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-1 receptor binding | IL1B,TRIP6,IL1RAP,TLR9,TLR5,IL36A,IL1A,IL36B,IL36G,IL36RN |
| cytokine activity | IFNPHI2,Kitl,Fasl,OSTN,IFNA4,GDF6B,INHBA,IFNA8,Il2,IFNA10 |
Interacting Protein
IL37 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL37 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL37.
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References
- Lee, KW; Kim, DK; et al. Immune modulation by Bacillus subtilis-based direct-fed microbials in commercial broiler chickens. ANIMAL FEED SCIENCE AND TECHNOLOGY 200:76-85(2015).
- Hu, ZL; Chen, ZY; et al. Expression, purification of IL-38 in Escherichia coli and production of polyclonal antibodies. PROTEIN EXPRESSION AND PURIFICATION 107:76-82(2015).
