• Official Full Name

    interleukin 37

  • Overview

    The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported.
  • Synonyms

    interleukin 1 family, member 7 (zeta); Interleukin-1-related protein; FIL1Z; FIL1 zeta; IL-1 zeta; IL-1H4; IL-1RP1; IL-1X protein; IL1H4; IL1RP1; interleukin 1 family member 7; FIL1; interleukin 1, zeta; FIL1(ZETA); interleukin-1 family member 7; Interleukin-1 homolog 4; interleukin-1 superfamily z; Interleukin-1 zeta; IL-1X; IL-37; IL1F7; IL-1F7; interleukin-23; OTTHUMP00000162032; OTTHUMP00000162033; OTTHUMP00000162034; OTTHUMP00000162035; OTTHUMP00000162036; IL-1F7b (IL-1H4, IL-1H, IL-1RP1); IL1F7 (canonical product IL-1F7b); interleukin 37; IL37; IL-1H;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • E.coli
  • HEK293
  • Human Cells
  • Mammalian cells
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • Met
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL37-853H Active Recombinant Human IL37 E.coli Met Lys27-Asp192
Human IL1F7-318H Recombinant Human IL1F7 E.coli N/A
Human IL37-7843H Recombinant Human IL37 E.coli N/A
Human IL1F7-159H Recombinant Human Interleukin 1 Family, Member 7, His-tagged E.coli His
Human IL37-370H Recombinant Human IL37, His-tagged E.coli His
Human IL1F7-14171H Recombinant Human IL1F7, GST-tagged E.coli GST 1-218a.a.
Human IL37-142H Recombinant Human IL37 protein E.coli N/A
Human IL37-753H Recombinant Human IL37 protein E.coli N/A Lys 27-Asp 192
Human IL37-5237HCL Recombinant Human IL1F7 293 Cell Lysate HEK293 N/A
Human IL37-159H Recombinant Human IL37 protein, His-tagged E.coli His Val46-Asp218
Human IL37-108H Recombinant Human IL37 Protein E.coli
Human IL37-151H Recombinant Human IL37 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human IL37-0188H Recombinant Human IL37 protein, His-tagged E.coli His Lys27-Asp192
Human IL37-949HFL Recombinant Full Length Human IL37 Protein, C-Flag-tagged Mammalian cells Flag
Human IL37-3514H Recombinant Human IL37 Protein (Val46-Asp218), His tagged E.coli His Val46-Asp218
Human IL37-201H Recombinant Active Human IL37 Protein, His-tagged(C-ter) E.coli His(C-ter)
Human IL37-1175H Recombinant Human IL37 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IL37-1175H-B Recombinant Human IL37 Protein Pre-coupled Magnetic Beads HEK293
Human IL37-124H Active Recombinant Human IL37 Protein (Lys53-Asp218), C-His tagged, Animal-free, Carrier-free E.coli C-His Lys53-Asp218
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

IL37 involved in several pathways and played different roles in them. We selected most pathways IL37 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IL37 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

IL37 has several biochemical functions, for example, cytokine activity, interleukin-1 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL37 itself. We selected most functions IL37 had, and list some proteins which have the same functions with IL37. You can find most of the proteins on our site.

Function Related Protein
cytokine activityFGF2;GDF6B;IL18;BMP7A;Cxcl15;IFNA4;IL26;GREM1A;IFNW1
interleukin-1 receptor bindingIL1A;TRIP6;IRAK1;TLR5;IL1RN;IL36B;IRAK4;IL36G;IL37

IL37 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL37 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL37.


Research Area

Related articles

Hu, ZL; Chen, ZY; et al. Expression, purification of IL-38 in Escherichia coli and production of polyclonal antibodies. PROTEIN EXPRESSION AND PURIFICATION 107:76-82(2015).
Lee, KW; Kim, DK; et al. Immune modulation by Bacillus subtilis-based direct-fed microbials in commercial broiler chickens. ANIMAL FEED SCIENCE AND TECHNOLOGY 200:76-85(2015).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Can IL37 be used in children? 12/22/2022

The safety and efficacy of recombinant IL37 in children have not been established and need to be validated in further studies.

What is the action mechanism of IL37? 03/01/2022

The IL37 works by inhibiting the release of inflammatory mediators and regulating immune cell levels, thereby reducing the inflammatory response.

How long is the course of IL37? 10/13/2021

The length of treatment for IL37 varies depending on the severity of the disease and the patient's response, and generally requires long-term treatment.

Can IL37 be used to prevent inflammatory diseases? 08/04/2020

At present, there is not enough evidence to show that IL37 can be used to prevent inflammatory diseases, and further studies are needed to verify it.

Is IL37 suitable for the treatment of allergic diseases? 07/04/2019

IL37 has anti-inflammatory and immunomodulatory effects, and may have a certain effect on allergic diseases, but further studies are needed to verify it.

Can IL37 be taken orally? 05/30/2019

IL37 is currently mainly administered by injection, and oral administration studies are still under way.

Customer Reviews (3)

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    IL37 has a long half-life and is able to maintain stability and reliability during experiments.


      When using IL37 protein for experiments, it can meet specific experimental requirements and research purposes.


        IL37 products have a complete range of specifications and are suitable for experimental designs of different sizes and needs.

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