Active Recombinant Human IL37 Protein (Lys53-Asp218), C-His tagged, Animal-free, Carrier-free

• Cat.No.: IL37-124H
• Product Overview: Recombinant Human IL37 Protein (Lys53-Asp218) with C-His tag was expressed in E. coli and Animal-free as well as Carrier-free.

Specification

• Description: Interleukin-37 (IL-37) consists of 192 amino acids. IL-37 is a member of the interleukin-1 cytokine family. The primary function is binding to the interleukin-18 receptor (IL18R1 /IL-1Rrp) and then becoming a subunit to inhibit the activity of IL-18. This behavior often occurs between various immune responses. It also significantly affects the negative regulation of tumor necrosis factor production.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized
• Bio-activity: Measure by its ability to induce IL-8 secretion in human PBMCs. The ED50 for this effect is < 0.9 μg/mL.
• Molecular Mass: The protein has a calculated MW of 19.49 kDa.
  The protein migrates as 22 kDa under reducing condition (SDS-PAGE analysis).
• Protein Length: Lys53-Asp218
• Endotoxin: < 0.1 EU/μg of the protein by the LAL method.
• Purity: >95% as determined by SDS-PAGE analysis.
• Storage: This product is stable after storage at:
  -20 centigrade for 12 months in lyophilized state from date of receipt.
  -20 or -80 centigrade for 1 month under sterile conditions after reconstitution.
  Avoid repeated freeze/thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 8.0.
• Reconstitution: It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
• Shipping: The product is shipped with polar packs. Upon receipt, store it immediately at -20 centigrade or lower for long term storage.

Gene Information

• Gene Name: IL37 interleukin 37 [ Homo sapiens (human) ]
• Official Symbol: IL37
• Synonyms: IL37; interleukin 37; IL1F7, interleukin 1 family, member 7 (zeta); interleukin-37; FIL1; FIL1(ZETA); FIL1Z; IL 1F7; IL 1H4; IL 1RP1; interleukin 1; zeta; interleukin 1 homolog 4; interleukin 1 related protein; FIL1 zeta; IL-1 zeta; IL-1X protein; interleukin-23; interleukin 1, zeta; interleukin-1 homolog 4; interleukin-1 superfamily z; interleukin 1 family member 7; interleukin-1-related protein; IL-1F7b (IL-1H4, IL-1H, IL-1RP1); IL1F7 (canonical product IL-1F7b); IL-1H; IL-37; IL1F7; IL1H4; IL-1F7; IL-1H4; IL1RP1; IL-1RP1
• Gene ID: 27178
• mRNA Refseq: NM_014439
• Protein Refseq: NP_055254
• MIM: 605510
• UniProt ID: Q9NZH6

Reviews

01/16/2021

IL37 has a long half-life and is able to maintain stability and reliability during experiments.

02/28/2020

When using IL37 protein for experiments, it can meet specific experimental requirements and research purposes.

03/15/2019

IL37 products have a complete range of specifications and are suitable for experimental designs of different sizes and needs.

Q&As

Can IL37 be used in children?

The safety and efficacy of recombinant IL37 in children have not been established and need to be validated in further studies.

What is the action mechanism of IL37?

The IL37 works by inhibiting the release of inflammatory mediators and regulating immune cell levels, thereby reducing the inflammatory response.

How long is the course of IL37?

The length of treatment for IL37 varies depending on the severity of the disease and the patient's response, and generally requires long-term treatment.

Can IL37 be used to prevent inflammatory diseases?

At present, there is not enough evidence to show that IL37 can be used to prevent inflammatory diseases, and further studies are needed to verify it.

Is IL37 suitable for the treatment of allergic diseases?

IL37 has anti-inflammatory and immunomodulatory effects, and may have a certain effect on allergic diseases, but further studies are needed to verify it.

Can IL37 be taken orally?

IL37 is currently mainly administered by injection, and oral administration studies are still under way.