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Recombinant Human IL1RL1 Protein, DDK/His-tagged

Cat.No. : IL1RL1-535H
Product Overview : Recombinant Human IL1RL1(Lys19 – Phe328), transcript variant 2, fused with DDK/His tag at C-terminal was expressed in HEK293 cells.
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Description : The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants.
Source : HEK293 cells
Tag : DDK/His
Form : 1 x PBS, pH7.4, 10% glycerol.
Molecular Mass : 35 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : IL1RL1 interleukin 1 receptor-like 1 [ Homo sapiens ]
Official Symbol : IL1RL1
Synonyms : IL1RL1; interleukin 1 receptor-like 1; interleukin-1 receptor-like 1; DER4; FIT 1; homolog of mouse growth stimulation expressed; IL33R; ST2; ST2L; ST2V; T1; growth stimulation-expressed; interleukin 1 receptor-related protein; homolog of mouse growth stimulation-expressed; FIT-1; MGC32623;
Gene ID : 9173
mRNA Refseq : NM_003856
Protein Refseq : NP_003847
MIM : 601203
UniProt ID : Q01638

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Are there any splice variants of IL1RL1? 02/20/2022

IL1RL1 has multiple splice variants that differ in signaling capabilities.

What is the role of IL1RL1 in allergic responses? 11/15/2021

IL1RL1 suppresses allergic responses by inhibiting mast cell activation.

Does IL1RL1 have a role in autoimmune diseases? 10/09/2021

IL1RL1 is implicated in rheumatoid arthritis.

How does IL1RL1 affect cytokine production? 11/21/2020

IL1RL1 increases the production of IL-4 and IL-13.

What is the subcellular localization of IL1RL1? 08/13/2020

IL1RL1 is primarily membrane-bound.

Does IL1RL1 influence T-cell differentiation? 02/29/2020

IL1RL1 promotes Th2 cell differentiation.

How does IL1RL1 interact with its ligands? 01/17/2020

IL1RL1 binds to IL-33 and IL-36 to initiate signaling.

Is IL1RL1 expression altered in any cancers? 05/09/2018

IL1RL1 expression is altered in lung and breast cancer.

What post-translational modifications occur on IL1RL1? 03/28/2017

IL1RL1 undergoes glycosylation and phosphorylation.

How is IL1RL1 expression regulated in asthmatic conditions? 08/23/2016

IL1RL1 expression is upregulated in asthmatic conditions.

Customer Reviews (3)

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Reviews
07/25/2019

    High specificity in ELISA.

    01/30/2017

      Suitable for flow cytometry.

      07/13/2016

        Effective in allergy models.

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