Recombinant Human IL1RL1 Protein, Fc-tagged

• Cat.No.: IL1RL1-318H
• Product Overview: Recombinant human IL1RL1 protein with Fc tag was expressed in HEK293.

Specification

• Description: The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants.
• Source: HEK293
• Species: Human
• Tag: Fc
• Form: Lyophilized
• Molecular Mass: 61 kDa
• Protein length: 556
• AA Sequence: MGFWILAILTILMYSTAAKFSKQSW GLENEALIVRCPRQGKPSYTVDWYY SQTNKSIPTQERNRVFASGQLLKFL PAAVADSGIYTCIVRSPTFNRTGYA NVTIYKKQSDCNVPDYLMYSTVSGS EKNSKIYCPTIDLYNWTAPLEWFKN CQALQGSRYRAHKSFLVIDNVMTED AGDYTCKFIHNENGANYSVTATRSF TVKDEQGFSLFPVIGAPAQNEIKEV EIGKNANLTCSACFGKGTQFLAAVL WQLNGTKITDFGEPRIQQEEGQNQS FSNGLACLDMVLRIADVKEEDLLLQ YDCLALNLHGLRRHTVRLSRKNPID HHSIYCIIAVCSVFLMLINVLVIIL KMFWIEATLLWRDIAKPYKTRNDGK LYDAYVVYPRNYKSSTDGASRVEHF VHQILPDVLENKCGYTLCIYGRDML PGEDVVTAVETNIRKSRRHIFILTP QITHNKEFAYEQEVALHCALIQNDA KVILIEMEALSELDMLQAEALQDSL QHLMKVQGTIKWREDHIANKRSLNS KFWKHVRYQMPVPSKIPRKASSLTP LAAQKQ
• Purity: > 98%
• Applications: WB; ELISA; FACS; FC
• Stability: This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
• Storage: At -20 centigrade.
• Concentration: 1 mg/mL
• Storage Buffer: PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
• Reconstitution: Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.

Gene Information

• Gene Name: IL1RL1 interleukin 1 receptor-like 1 [ Homo sapiens (human) ]
• Official Symbol: IL1RL1
• Synonyms: IL1RL1; interleukin 1 receptor-like 1; interleukin-1 receptor-like 1; DER4; FIT 1; homolog of mouse growth stimulation expressed; IL33R; ST2; ST2L; ST2V; T1; growth stimulation-expressed; interleukin 1 receptor-related protein; homolog of mouse growth stimulation-expressed; FIT-1; MGC32623
• Gene ID: 9173
• mRNA Refseq: NM_003856
• Protein Refseq: NP_003847
• MIM: 601203
• UniProt ID: Q01638

Reviews

07/25/2019

High specificity in ELISA.

01/30/2017

Suitable for flow cytometry.

07/13/2016

Effective in allergy models.

Q&As

Are there any splice variants of IL1RL1?

IL1RL1 has multiple splice variants that differ in signaling capabilities.

What is the role of IL1RL1 in allergic responses?

IL1RL1 suppresses allergic responses by inhibiting mast cell activation.

Does IL1RL1 have a role in autoimmune diseases?

IL1RL1 is implicated in rheumatoid arthritis.

How does IL1RL1 affect cytokine production?

IL1RL1 increases the production of IL-4 and IL-13.

What is the subcellular localization of IL1RL1?

IL1RL1 is primarily membrane-bound.

Does IL1RL1 influence T-cell differentiation?

IL1RL1 promotes Th2 cell differentiation.

How does IL1RL1 interact with its ligands?

IL1RL1 binds to IL-33 and IL-36 to initiate signaling.

Is IL1RL1 expression altered in any cancers?

IL1RL1 expression is altered in lung and breast cancer.

What post-translational modifications occur on IL1RL1?

IL1RL1 undergoes glycosylation and phosphorylation.

How is IL1RL1 expression regulated in asthmatic conditions?

IL1RL1 expression is upregulated in asthmatic conditions.