Recombinant Human IL21, StrepII-tagged
Cat.No. : | IL21-292H |
Product Overview : | Purified, full-length human recombinant IL21 protein (amino acids 23-155, 133 a.a.) with StrepII tag, produced in human cells. Predicted molecular weight: 15.5 kDa. (Accession NP_001193935; UniProt Q9HBE4) |
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Description : | IL21 is a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. |
Source : | Human Cells |
Species : | Human |
Tag : | StrepII |
Form : | Lyophilized from sterile 0.2μm filtered solution in 0.3X PBS with 10% Trehalose (carrier-free) |
Protein length : | 23-155, 133 a.a. |
AA Sequence : | QGQDRHMIRMRQLIDIVDQLKNYVN DLVPEFLPAPEDVETNCEWSAFSCF QKAQLKSANTGNNERIINVSIKKLK RKPPSTNAGRRQKHRLTCPSCDSYE KKPPKEFLERFKSLLQKMIHQHLSS RTHGSEDS |
Endotoxin : | <0.1 eu per μg protein by lal |
Purity : | 90% by SDS-PAGE |
Storage : | 12 months at -20°C as supplied; 1 month at 4°C after reconstitution. Avoid freeze/thaw cycles. |
Reconstitution : | Centrifuge the vial prior to opening. Reconstitute in PBS to a concentration of 0.1 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for up to 1 month. |
Gene Name : | IL21 interleukin 21 [ Homo sapiens ] |
Official Symbol : | IL21 |
Synonyms : | IL21; interleukin 21; interleukin-21; IL 21; Za11; interleukin-21 isoform; IL-21; |
Gene ID : | 59067 |
mRNA Refseq : | NM_001207006 |
Protein Refseq : | NP_001193935 |
MIM : | 605384 |
UniProt ID : | Q9HBE4 |
Chromosome Location : | 4q26-q27 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem; |
Function : | cytokine activity; cytokine receptor binding; interleukin-2 receptor binding; |
Products Types
◆ Recombinant Protein | ||
IL21-4336R | Recombinant Rabbit IL21 Protein | +Inquiry |
Il21-265M | Active Recombinant Mouse Il21 Protein (His18-Ser146), C-His tagged, Animal-free, Carrier-free | +Inquiry |
il21-4335S | Recombinant Salmon il21 Protein | +Inquiry |
IL21-16H | Active Recombinant Human IL21 Protein, Fc-Avi-tagged, Biotinylated | +Inquiry |
Il21-10M | Active Recombinant Mouse Il21 Protein | +Inquiry |
◆ Lysates | ||
IL21-001RCL | Recombinant Rat IL21 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionIL21 has demonstrated efficacy in preclinical and clinical studies for various cancers, including melanoma, renal cell carcinoma, and lymphoma.
Common side effects may include fatigue, fever, and flu-like symptoms. However, the severity and type of side effects can vary among individuals.
IL21 is often investigated in combination with other cancer therapies to enhance its effectiveness, and it has shown promise in combination treatments.
Yes, several clinical trials are investigating the efficacy and safety of IL21 in autoimmune diseases, such as rheumatoid arthritis and lupus.
IL21 promotes the differentiation and survival of memory T cells, contributing to the long-term immune response against pathogens.
Customer Reviews (3)
Write a reviewWith the IL21 protein at hand, I am excited to embark on my scientific journey with confidence and optimism.
I am confident that incorporating the IL21 protein into my research will yield accurate and reliable results, enabling deeper insights into cellular processes
Their expertise and guidance will undoubtedly prove valuable in overcoming hurdles and maximizing the potential of this protein in my research endeavors.
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