Recombinant Swine IL21
Cat.No. : | IL21-103S |
Product Overview : | Swine IL-21 was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified. |
- Specification
- Gene Information
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Description : | IL-21 is a member of the type I cytokine family, which includes IL-2 and IL-15. IL-21 signals through the common gamma-chain and a unique IL-21 receptor. The IL-21 receptor is expressed in cells lymphoid-lineage and regulates the proliferation and differentiation of T and B lymphocytes. Studies suggest that IL-21 is a key component of CD4 T cell help that is required for maintaining the CD8+ T cell responses and inducing B cell antibody response. IL-21 also promotes the development of Th17 and Tfh cells, modulates the cytotoxic activity and survival of NK and CD8+ T cells, and suppresses the maturation of dendritic cells. It is also implicated in the development of autoimmune disease and has antitumor activity. |
Source : | Yeast |
Species : | Swine |
Form : | Lyophilized without carrier protein. |
Molecular Mass : | Swine IL-21 has a predicted molecular weight of 15.0 kDa. |
AA Sequence : | HKSSFQGQDR LLIRLRQLID TVDQLKNYVH DLDPELLPAP EDVQRHCEQS AFSCFQKVEL KSANTGDNEK IINVLIKQLK RKLPPTNAGR RQKHGLTCPT CDSYEKKPIK EFLERLKSLI QKMIHQHLS |
Purity : | >95% as visualized by SDS-PAGE analysis. |
Applications : | The Swine IL-21 protein can be used in cell culture, as an IL-21 ELISA Standard, and as a Western Blot Control. |
Storage : | Stable for up to twelve months from date of receipt at -20?C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20?C. Avoid repeated freeze/thaw cycles. |
Reconstitution : | Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein. |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionIL21 has demonstrated efficacy in preclinical and clinical studies for various cancers, including melanoma, renal cell carcinoma, and lymphoma.
Common side effects may include fatigue, fever, and flu-like symptoms. However, the severity and type of side effects can vary among individuals.
IL21 is often investigated in combination with other cancer therapies to enhance its effectiveness, and it has shown promise in combination treatments.
Yes, several clinical trials are investigating the efficacy and safety of IL21 in autoimmune diseases, such as rheumatoid arthritis and lupus.
IL21 promotes the differentiation and survival of memory T cells, contributing to the long-term immune response against pathogens.
Customer Reviews (3)
Write a reviewWith the IL21 protein at hand, I am excited to embark on my scientific journey with confidence and optimism.
I am confident that incorporating the IL21 protein into my research will yield accurate and reliable results, enabling deeper insights into cellular processes
Their expertise and guidance will undoubtedly prove valuable in overcoming hurdles and maximizing the potential of this protein in my research endeavors.
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