Recombinant Rat Il21 Protein, His-tagged

• Cat.No.: Il21-1672R
• Product Overview: Recombinant Rat Il21 Protein (Met1-Ser146) with N-His tag was expressed in E. coli.

Specification

• Description: Predicted to enable interleukin-2 receptor binding activity. Predicted to be involved in several processes, including lymphocyte activation involved in immune response; positive regulation of immune effector process; and tyrosine phosphorylation of STAT protein. Predicted to act upstream of or within positive regulation of cytokine production; positive regulation of lymphocyte activation; and positive regulation of tyrosine phosphorylation of STAT protein. Predicted to be located in extracellular space. Biomarker of periodontal disease. Human ortholog(s) of this gene implicated in asthma; common variable immunodeficiency; hepatocellular carcinoma; and systemic lupus erythematosus. Orthologous to human IL21 (interleukin 21).
• Source: E. coli
• Species: Rat
• Tag: His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 17.1 kDa
  Accurate Molecular Mass: 21 kDa
• Protein length: Met1-Ser146
• Purity: > 97%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: Il21 interleukin 21 [ Rattus norvegicus (Norway rat) ]
• Official Symbol: Il21
• Synonyms: IL21; interleukin 21; interleukin-21; IL-21
• Gene ID: 365769
• mRNA Refseq: NM_001108943
• Protein Refseq: NP_001102413
• UniProt ID: A3QPB9

Reviews

08/19/2022

With the IL21 protein at hand, I am excited to embark on my scientific journey with confidence and optimism.

01/30/2022

I am confident that incorporating the IL21 protein into my research will yield accurate and reliable results, enabling deeper insights into cellular processes

04/23/2019

Their expertise and guidance will undoubtedly prove valuable in overcoming hurdles and maximizing the potential of this protein in my research endeavors.

Q&As

In which types of cancer has IL21 protein shown promising results?

IL21 has demonstrated efficacy in preclinical and clinical studies for various cancers, including melanoma, renal cell carcinoma, and lymphoma.

Are there any side effects associated with IL21 therapy?

Common side effects may include fatigue, fever, and flu-like symptoms. However, the severity and type of side effects can vary among individuals.

Can IL21 be used as a standalone treatment for cancer?

IL21 is often investigated in combination with other cancer therapies to enhance its effectiveness, and it has shown promise in combination treatments.

Are there any ongoing clinical trials exploring the use of IL21 in autoimmune conditions?

Yes, several clinical trials are investigating the efficacy and safety of IL21 in autoimmune diseases, such as rheumatoid arthritis and lupus.

How does IL21 influence the development of memory T cells?

IL21 promotes the differentiation and survival of memory T cells, contributing to the long-term immune response against pathogens.