IL21
-
Official Full Name
interleukin 21
-
Background
A novel cytokine related to IL2 and IL15 was recently identified and designated IL21. IL21 has been found to be a powerful growth factor for naive B cells. The receptor for IL21 (IL21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL21 signaling. Both IL21R and the gc are necessary for the IL21 function. IL21 and its receptor activate JAKSTAT signaling pathway. IL21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL21 plays a role in the proliferation and maturation of NK, B and T cell populations. -
Synonyms
IL21; interleukin 21; interleukin-21; IL-21; Il21;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL21 Related Articles
- IL21 Related Research Area
IL21 involved in several pathways and played different roles in them. We selected most pathways IL21 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with IL21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | CCL4L1;NGFR;EDAR;CCR9;IL21R;CSF2;IL2RG;CD70;GHRA |
| Jak-STAT signaling pathway | CNTF;IFNAR1;IFNPHI1;IL6ST;IL20RB;BCL2L1;BCL2A;SOCS6B;HRASB |
| Inflammatory bowel disease (IBD) | RORC;IL23;HLA-DOA;IL12B;RELA;HLA-DRB4;HLA-DRA;STAT6;Il2 |
IL21 has several biochemical functions, for example, cytokine activity, cytokine receptor binding, interleukin-2 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL21 itself. We selected most functions IL21 had, and list some proteins which have the same functions with IL21. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | TNFSF8;Gm13290;TGFB1;CD70;IFNA1;IFNE;GRN;KITLG;INHBAA |
| cytokine receptor binding | IFNA13;IFNW1;MIF;IL17A/F1;IL15L;IFN-a;IFNPHI3;IFNA8;IL17F |
| interleukin-2 receptor binding | GATA3;TIMM50;Il2;IL21;ECM1 |
IL21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL21 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL21.
PARP2; DGKA
- Q&As
- Reviews
Ask a Question for All IL21 Products
Required fields are marked with *
My Review for All IL21 Products
Required fields are marked with *