Recombinant Human IL33, His-tagged
Cat.No. : | IL33-322H |
Product Overview : | Total 169 AA. MW: 19.2 kDa (calculated). N-Terminal His-tag, 10 extra AA (highlighted). |
- Specification
- Gene Information
- Related Products
Cat. No. : | IL33-322H |
Description : | IL33 is a cytokine belonging to the IL-1 superfamily. IL33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. This cytokine was previously named NF-HEV "nuclear factor (NF) in high endothelial venules, (HEVs) since it was originally identified in these specialized cells. IL-33 mediates its biological effects by interacting with the receptors ST2 (aka IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-μB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. The induction of type 2 cytokines by IL33 in vivo is believed to induce the severe pathological changes observed in mucosal organs following administration of IL33. |
Source : | E. coli |
Species : | Human |
Form : | Filtered (0,4 μm) and lyophilized in 0.5 mg/mL in 20 mM TRIS, 50 mM NaCl, Ph 7.5 |
Research topic : | Energy metabolism and body weight regulation |
Purity : | >95% |
Reconstitution : | Add deionized water to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
Applications : | Western blotting |
Quality Control Test : | BCA to determine quantity of the protein; SDS PAGE to determine purity of the protein. |
Sequences of amino acids : | MKHHHHHHAS SITGISPITE YLASLSTYND QSITFALEDE SYEIYVEDLK KDEKKDKVLL SYYESQHPSN ESGDGVDGKM LMVTLSPTKD FWLHANNKEH SVELHKCEKP LPDQAFFVLH NMHSNCVSFE CKTDPGVFIG VKDNHLALIK VDSSENLCTE NILFKLSET |
Storage : | Store lyophilized protein at -20°C. Lyophilized protein remains stable until the expiry date when stored at -20°C. Aliquot reconstituted protein to avoid repeated freezing/thawing cycles and store at -80°C for long term storage. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after one week at 4°C. |
Gene Name : | IL33 interleukin 33 [ Homo sapiens ] |
Official Symbol : | IL33 |
Synonyms : | IL33; interleukin 33; DVS27; NF-HEV; NFEHEV; C9orf26; DKFZp586H0523; RP11-575C20.2; DVS27-related protein; nuclear factor from high endothelial venules; chromosome 9 open reading frame 26 (NF-HEV); IL-1F11; IL-33; IL1F11; NFHEV; OTTHUMP00000021041; Interleukin-1 family member 11; Nuclear factor from high endothelial venules |
Gene ID : | 90865 |
mRNA Refseq : | NM_033439 |
Protein Refseq : | NP_254274 |
MIM : | 608678 |
UniProt ID : | O95760 |
Chromosome Location : | 9p24 |
Pathway : | cytosolic DNA-sensing pathway; Influenza A |
Function : | cytokine activity; protein binding |
Products Types
◆ Recombinant Protein | ||
Il33-1679M | Recombinant Mouse Il33 Protein, His-tagged | +Inquiry |
Il33-192M | Recombinant Active Mouse IL33 Protein, His-tagged(C-ter) | +Inquiry |
IL33-175M | Active Recombinant Mouse IL33 Protein | +Inquiry |
IL33-1917M | Recombinant Mouse IL33 Protein | +Inquiry |
IL33-2313H | Recombinant Human IL33 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
IL33-5226HCL | Recombinant Human IL33 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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Q&As (6)
Ask a questionIt can be used to detect immune cells such as macrophages and dendritic cells.
This protein applied in immunology, drug research, life science and other fields.
Regulates the activity of immune cells by binding to receptors to stimulate the production of inflammatory factors such as interferon and TNF-α.
IL33 can also be used to treat a variety of inflammatory diseases, such as inflammatory bowel disease, psoriasis and so on.
The preparation of IL33 requires first cloning the IL33 gene into the expression vector, and then the expression vector is expressed and purified in the cell culture medium.
Treating asthma with recombinant IL33 takes several weeks to several months to be effective, depending on the severity of the condition and the individual patient.
Customer Reviews (3)
Write a reviewGood solubility and is easy to operate and purify.
Effectively mimics the function of the target protein in vitro.
IL33 has a wide range of applications in the field of scientific research and is suitable for a variety of experimental design and research purposes.
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