Recombinant Rat Interleukin 33

Cat.No. : Il33-286R
Product Overview : Recombinant rat IL-33 (aa 109-264) was expressed in E. coli, ~16kDa.
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Cat. No. : Il33-286R
Description : IL-33 is a new member of the IL-1 family. It is involved in T helper type 2 response via the activation of its receptor ST2 (IL-1RL1) driving the production of Th2-associated cytokines. The stimulation of ST2 by IL-33 induces the NF-κB and MAPK pathways. The human IL-33 protein is expressed with a prodomain (aa 1-111) which is cleaved by caspase-1 to produce the 18kDa mature protein (112-270).
Source : E. coli.
Purity : ≥95% (SDS-PAGE).
Concentration : 0.1mg/ml after reconstitution.
Formulation : Lyophilized. Contains PBS.
Endotoxin Content : <0.1EU/µg purified protein (LAL test; Bio Whittaker).
Reconstitution : Reconstitute with 100µl sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum.
Long Term Storage : -20°C.
Use/Stability : Stable for at least 6 months after receipt when stored at -20°C.
Handling : After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Gene Name : Il33 interleukin 33 [ Rattus norvegicus ]
Synonyms : interleukin 33; RGD1311155; Il33; interleukin-33; IL-33
Gene ID : 361749
mRNA Refseq : NM_001014166
Protein Refseq : NP_001014188
UniProt ID : Q66H70
Chromosome Location : 1q52
Pathway : Cytosolic DNA-sensing pathway
Function : cytokine activity; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Which immune cells can recombinant IL33 be used to detect? 05/28/2022

It can be used to detect immune cells such as macrophages and dendritic cells.

In what research fields can recombinant IL33 be applied? 09/24/2020

This protein applied in immunology, drug research, life science and other fields.

What is the action mechanism of IL33? 08/09/2020

Regulates the activity of immune cells by binding to receptors to stimulate the production of inflammatory factors such as interferon and TNF-α.

Besides treating asthma and hay fever, what other diseases can be treated with IL33? 07/28/2019

IL33 can also be used to treat a variety of inflammatory diseases, such as inflammatory bowel disease, psoriasis and so on.

How to prepare IL33? 03/25/2019

The preparation of IL33 requires first cloning the IL33 gene into the expression vector, and then the expression vector is expressed and purified in the cell culture medium.

How long does it take to treat asthma with IL33? 01/10/2019

Treating asthma with recombinant IL33 takes several weeks to several months to be effective, depending on the severity of the condition and the individual patient.

Customer Reviews (3)

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Reviews
10/16/2021

    Good solubility and is easy to operate and purify.

    05/03/2021

      Effectively mimics the function of the target protein in vitro.

      03/18/2020

        IL33 has a wide range of applications in the field of scientific research and is suitable for a variety of experimental design and research purposes.

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