Recombinant Rat Interleukin 33
Cat.No. : | Il33-286R |
Product Overview : | Recombinant rat IL-33 (aa 109-264) was expressed in E. coli, ~16kDa. |
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Cat. No. : | Il33-286R |
Description : | IL-33 is a new member of the IL-1 family. It is involved in T helper type 2 response via the activation of its receptor ST2 (IL-1RL1) driving the production of Th2-associated cytokines. The stimulation of ST2 by IL-33 induces the NF-κB and MAPK pathways. The human IL-33 protein is expressed with a prodomain (aa 1-111) which is cleaved by caspase-1 to produce the 18kDa mature protein (112-270). |
Source : | E. coli. |
Purity : | ≥95% (SDS-PAGE). |
Concentration : | 0.1mg/ml after reconstitution. |
Formulation : | Lyophilized. Contains PBS. |
Endotoxin Content : | <0.1EU/µg purified protein (LAL test; Bio Whittaker). |
Reconstitution : | Reconstitute with 100µl sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum. |
Long Term Storage : | -20°C. |
Use/Stability : | Stable for at least 6 months after receipt when stored at -20°C. |
Handling : | After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
Tag : | Non |
Gene Name : | Il33 interleukin 33 [ Rattus norvegicus ] |
Synonyms : | interleukin 33; RGD1311155; Il33; interleukin-33; IL-33 |
Gene ID : | 361749 |
mRNA Refseq : | NM_001014166 |
Protein Refseq : | NP_001014188 |
UniProt ID : | Q66H70 |
Chromosome Location : | 1q52 |
Pathway : | Cytosolic DNA-sensing pathway |
Function : | cytokine activity; protein binding |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewGood solubility and is easy to operate and purify.
Effectively mimics the function of the target protein in vitro.
IL33 has a wide range of applications in the field of scientific research and is suitable for a variety of experimental design and research purposes.
Q&As (6)
Ask a questionIt can be used to detect immune cells such as macrophages and dendritic cells.
This protein applied in immunology, drug research, life science and other fields.
Regulates the activity of immune cells by binding to receptors to stimulate the production of inflammatory factors such as interferon and TNF-α.
IL33 can also be used to treat a variety of inflammatory diseases, such as inflammatory bowel disease, psoriasis and so on.
The preparation of IL33 requires first cloning the IL33 gene into the expression vector, and then the expression vector is expressed and purified in the cell culture medium.
Treating asthma with recombinant IL33 takes several weeks to several months to be effective, depending on the severity of the condition and the individual patient.
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