Recombinant Human IL33 Protein
Cat.No. : | IL33-110H |
Product Overview : | Recombinant Human Interleukin-33 is produced by our E.coli expression system and the target gene encoding Ser112-Thr270 is expressed. |
- Specification
- Gene Information
- Related Products
Description : | Interleukin-33 (IL-33) was initially discovered as a nuclear factor NF-HEV abundantly expressed in high endothelial venules. It is a 30-32 kD pro-inflammatory protein with intracellular and extracellular activities and a chromatin-associated cytokine of the IL-1 family with high sequence and structural similarity to IL-1 and IL-18. IL-33 is highly and selectively expressed by high endothelial venule endothelial cells (HEVECs) in human tonsils, Peyers's patches, and lymph nodes. It contains a bipartite nuclear localization signal at the C-terminus, and is targeted to the nucleus when ectopically expressed in human umbilical vein endothelial cells (HUVECs) and HeLa cells. The C-terminal fragment, corresponding to mature IL-33, binds and triggers signaling. IL-33 mediates its biological effects via Toll-interleukin 1 (IL-1) receptor (TIR) domain-containing receptor ST2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines from in vitro polarized T(H)2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs. Human IL-33 is 270 amino acids in length. |
Source : | E. coli |
Species : | Human |
Form : | Lyophilized from a 0.2 um filtered solution of 20mM TrisHCl, 150mM NaCl, pH 7.5. |
AA Sequence : | Ser112-Thr270 |
Endotoxin : | Less than 0.1 ng/ug (1 EU/ug). |
Purity : | >90% |
Storage : | Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 centigrade for 2-7 days. Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months. Always centrifuge tubes before opening. Do not mix by vortex or pipetting |
Reconstitution : | It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Quality Statement : | Purity: greater than 90% as determined by reducing SDS-PAGE. |
Shipping : | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
Gene Name : | IL33 interleukin 33 [ Homo sapiens (human) ] |
Official Symbol : | IL33 |
Synonyms : | Interleukin-33; IL-33; Interleukin-1 Family Member 11; IL-1F11; Nuclear Factor From High Endothelial Venules; NF-HEV; IL33; C9orf26; IL1F11; NFHEV; DVS27; IL1F11; NFEHEV |
Gene ID : | 90865 |
mRNA Refseq : | NM_001199640.2 |
Protein Refseq : | NP_001186569.1 |
MIM : | 608678 |
UniProt ID : | O95760 |
Products Types
◆ Recombinant Protein | ||
IL33-2313H | Recombinant Human IL33 Protein, His-tagged | +Inquiry |
IL33-312H | Active Recombinant Human IL33 Protein (Ser112-Thr270), C-His tagged, Animal-free, Carrier-free | +Inquiry |
IL33-356I | Active Recombinant Human IL33 Protein (159 aa) | +Inquiry |
IL33-1917M | Recombinant Mouse IL33 Protein | +Inquiry |
Il33-5186M | Active Recombinant Mouse Il33 Protein | +Inquiry |
◆ Lysates | ||
IL33-5226HCL | Recombinant Human IL33 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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