| Description : |
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
His |
| Form : |
Lyophilized |
| Molecular Mass : |
24.5 kDa |
| Protein Length : |
825 |
| AA Sequence : |
MGWLCSGLLFPVSCLVLLQVASSGN MKVLQEPTCVSDYMSISTCEWKMNG PTNCSTELRLLYQLVFLLSEAHTCI PENNGGAGCVCHLLMDDVVSADNYT LDLWAGQQLLWKGSFKPSEHVKPRA PGNLTVHTNVSDTLLLTWSNPYPPD NYLYNHLTYAVNIWSENDPADFRIY NVTYLEPSLRIAASTLKSGISYRAR VRAWAQCYNTTWSEWSPSTKWHNSY REPFEQHLLLGVSVSCIVILAVCLL CYVSITKIKKEWWDQIPNPARSRLV AIIIQDAQGSQWEKRSRGQEPAKCP HWKNCLTKLLPCFLEHNMKRDEDPH KAAKEMPFQGSGKSAWCPVEISKTV LWPESISVVRCVELFEAPVECEEEE EVEEEKGSFCASPESSRDDFQEGRE GIVARLTESLFLDLLGEENGGFCQQ DMGESCLLPPSGSTSAHMPWDEFPS AGPKEAPPWGKEQPLHLEPSPPASP TQSPDNLTCTETPLVIAGNPAYRSF SNSLSQSPCPRELGPDPLLARHLEE VEPEMPCVPQLSEPTTVPQPEPETW EQILRRNVLQHGAAAAPVSAPTSGY QEFVHAVEQGGTQASAVVGLGPPGE AGYKAFSSLLASSAVSPEKCGFGAS SGEEGYKPFQDLIPGCPGDPAPVPV PLFTFGLDREPPRSPQSSHLPSSSP EHLGLEPGEKVEDMPKPPLPQEQAT DPLVDSLGSGIVYSALTCHLCGHLK QCHGQEDGGQTPVMASPCCGCCCGD RSSPPTTPLRAPDPSPGGVPLEASL CPASLAPSGISEKSKSSSSFHPAPG NAQSSSQTPKIVNFVSVGPTYMRVS |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
