IL4R
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Official Full Name
interleukin 4 receptor
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Background
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. -
Synonyms
IL4R; interleukin 4 receptor; interleukin-4 receptor subunit alpha; CD124; IL-4 receptor subunit alpha; interleukin-4 receptor alpha chain; IL4RA; IL-4RA;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL4R Related Articles
- IL4R Related Gene Family
- IL4R Related Research Area
IL4R involved in several pathways and played different roles in them. We selected most pathways IL4R participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL4R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | ACVR1BA;IFNAR2;IL6;VEGFB;BMPR1BA;CCL15;CD40LG;CXCL14;CCR10 |
| PIK-Akt signaling pathway | GSK3B;PPP2CA;COL27A1;RAC1;EIF4E1B;IL3RA;FGF1;FGFR4;ATF4 |
| Jak-STAT signaling pathway | GHR;PRLR;IL28RA;GFAP;HRAS;AKT3A;IFNA16;IL-15RA;IRX1 |
| Hematopoietic cell lineage | IL4;IL4R;CD3D;TNF;CD8B1;CD3G;HLA-DRB1;CSF3;CR1 |
| Inflammatory bowel disease (IBD) | Il4ra;Il23a;TGFB3;IL12RB1;IFNG;STAT6;HLA-DQA1;IL23;FOXP3 |
IL4R has several biochemical functions, for example, interleukin-4 receptor activity, protein binding, receptor signaling protein activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL4R itself. We selected most functions IL4R had, and list some proteins which have the same functions with IL4R. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-4 receptor activity | |
| protein binding | SIL1;MYOC;LACTB2;RAPGEF4;FLVCR1;C22orf23;CALB1;MYH7B;CDK4 |
| receptor signaling protein activity | TRAIP;RGS12B;CD3E;DOK4;RGS14;RAF1B;BAG4;IL1RL1;DOK1 |
IL4R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL4R here. Most of them are supplied by our site. Hope this information will be useful for your research of IL4R.
IL4; IL2RG; STAT6; IL13RA1
- Q&As
- Reviews
Q&As (6)
Ask a questionIL4R is a synthetic protein that mimics the IL-4 signaling pathway in nature and binds to the IL-4 receptor in cells, which can be used to study the IL-4 signaling pathway and related diseases.
Common IL4R production technologies include prokaryotic expression systems and mammalian cell expression systems.
This protein is used in tumor immunotherapy, which can promote anti-tumor immune response and enhance the anti-tumor effect of cytotoxic T lymphocytes.
It is mainly used in immunology, drug research and other fields. It is also widely used in vaccines, biotechnology, cancer treatment and so on.
IL4R is used to treat severe pheochromocytome-induced aerodoritis and was approved by the FDA as the first drug to treat this disease.
IL4R cannot generally be administered orally, and needs to be administered by injection or intravenous drip.
Customer Reviews (3)
Write a reviewIn production, microorganisms such as Escherichia coli are often used as hosts for protein production, and there are often a large number of exogenous proteases and other background qualities in these host cells. Therefore, corresponding processing methods such as fusion of green fluorescent protein should be considered to avoid non-specific enzyme degradation of IL4R. -
When producing IL4R, it is necessary to pay attention to the purity of the protein, and the separation technology such as chromatography and identification methods such as SDS-PAGE are usually used for accurate purity identification. -
The biological function of IL4R, namely activity, is an important index to evaluate its quality, which can be identified by cell culture experiment, ELISA and other methods. -
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