IL4R Protein

IL4R

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IL4R

Official Full Name interleukin 4 receptor
Background This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.
Synonyms IL4R; interleukin 4 receptor; interleukin-4 receptor subunit alpha; CD124; IL-4 receptor subunit alpha; interleukin-4 receptor alpha chain; IL4RA; IL-4RA
    • Species :
    • Cynomolgus/Rhesus macaque
    • Homo sapiens (Human)
    • Human
    • Mus musculus (Mouse)
    • Pig
    • Rat
    • Source :
    • A293 cells
    • CHO
    • E.coli
    • E.coli expression system
    • HEK293
    • HEK293 cells
    • Human Cell
    • In Vitro Cell Free System
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Yeast
    • Tag :
    • Fc
    • Fc/Avi
    • GST
    • His
    • Avi
    • SUMOstar
    • human
    • IgG1
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL4R-588H Active Recombinant Human IL4R Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi Inquiry
    Human IL4R-051H Active Recombinant Human IL4R protein, Fc/Avi-tagged, Biotinylated HEK293 cells Fc/Avi Inquiry
    Human IL4R-1238H Recombinant Human Interleukin 4 Receptor A293 cells N/A Inquiry
    Human IL4R-1645H Recombinant Human Interleukin 4 Receptor Mammalian cells N/A Inquiry
    Human IL4R-284H Recombinant Human Interleukin 4 Receptor, His-tagged Mammalian Cell His Inquiry
    Human IL4R-28641TH Recombinant Human IL4R, Fc-tagged Fc Inquiry
    Human IL4R-586H Recombinant Human Interleukin 4 Receptor HEK293 N/A Inquiry
    Human IL4R-587H Recombinant Human IL4R protein, His-tagged HEK293 His Inquiry
    Rat Il4r-2131R Recombinant Rat Il4r protein, His-tagged E.coli His Inquiry
    Rat Il4r-379R Recombinant Rat Il4r, Fc tagged Human Cell Fc Inquiry
    Cynomolgus/Rhesus macaque IL4R-18C Recombinant Cynomolgus/Rhesus macaque IL4R protein, His-tagged HEK293 His Inquiry
    Cynomolgus/Rhesus macaque IL4R-19C Recombinant Cynomolgus/Rhesus macaque IL4R protein, Fc-tagged HEK293 human/IgG1/Fc Inquiry
    Human IL4R-2719HCL Recombinant Human IL4R cell lysate Human Cell N/A Inquiry
    Rat IL4R-1051RCL Recombinant Rat IL4R cell lysate Human Cell N/A Inquiry
    Human IL4R-01H Recombinant Human IL4R Protein CHO Inquiry
    Human IL4R-2321H Recombinant Human IL4R Protein, His-tagged E.coli N-His Inquiry
    Human IL4R-2883H Recombinant Human IL4R protein, His-tagged E.coli His Inquiry
    Human IL4R-301368H Recombinant Human IL4R protein, GST-tagged E.coli GST Inquiry
    Human IL4R-5681HF Recombinant Full Length Human IL4R Protein In Vitro Cell Free System Inquiry
    Pig IL4R-5796P Recombinant Pig IL4R protein, His-tagged Yeast His Inquiry
    Mus musculus (Mouse) RFL13636MF Recombinant Full Length Mouse Interleukin-4 Receptor Subunit Alpha(Il4R) Protein, His-Tagged E.coli expression system His Inquiry
    Homo sapiens (Human) RFL28517HF Recombinant Full Length Human Interleukin-4 Receptor Subunit Alpha(Il4R) Protein, His-Tagged E.coli expression system His Inquiry
    Human IL4R-2037H Recombinant Human IL4R Protein, His-tagged HEK293 His Inquiry
    Human IL4R-390H Recombinant Human IL4R protein, Fc-tagged HEK293 human/IgG1/Fc Inquiry
    Human IL4R-5179H Recombinant Human IL4R Protein, GST-tagged Wheat Germ GST Inquiry
    Human IL4R-5180H Recombinant Human IL4R Protein Wheat Germ N/A Inquiry
    Human IL4R-587HB Recombinant Human IL4R protein, His-tagged, Biotinylated HEK293 His Inquiry
    Pig IL4R-2388P Recombinant Pig IL4R Protein (33-240 aa), His-tagged E.coli His Inquiry
    Pig IL4R-2437P Recombinant Pig IL4R Protein (33-240 aa), His-sumostar-tagged Yeast His/SUMOstar Inquiry

    IL4R involved in several pathways and played different roles in them. We selected most pathways IL4R participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL4R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction TNFRSF9A; IL17A; CCL3L1; TNFSF18; CCL26; TSLP; KITLGA; TNFSF15; IL15RA; IL23R
    PIK-Akt signaling pathway GNG10; GNG5; DDIT4; PHLPP2; IL7R; FGF11; Gh; SGK1; ITGA9; GNG3
    Jak-STAT signaling pathway AKT1; IL13; IL28RA; IL24; HRASB; GRB2; IL9R; LEP; IL12B; IL29
    Hematopoietic cell lineage IL7R; IL1B; CD8B; ITGA4; GP5; EPOR; CSF3R; CD34; HLA-DRB3; CD5
    Inflammatory bowel disease (IBD) NFATC1; TBX21; HLA-DQB1; STAT4; IL2RG; IFNGR1; IL12A; HLA-DRA; Il23a; Il12b; TGFB3

    IL4R has several biochemical functions, for example, interleukin-4 receptor activity, protein binding, receptor signaling protein activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL4R itself. We selected most functions IL4R had, and list some proteins which have the same functions with IL4R. You can find most of the proteins on our site.

    Function Related Protein
    interleukin-4 receptor activity IL4R
    protein binding KIAA0101; GPN1; FSHR; PEX13; APLP1; EPB41B; GGPS1; USP15; SFTPD; HNRNPR
    receptor signaling protein activity SMAD1; IL1RL1; Siglece; BAG1; CD19; PLCG1; BAG4; cgr2b; DCLK1; ADRB1

    IL4R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL4R here. Most of them are supplied by our site. Hope this information will be useful for your research of IL4R.

    IL4; IL2RG; STAT6; IL13RA1

    Biedermann, T; Werfel, T; et al. Status quo and prospects for systemic therapy of atopic dermatitis. Biologics ante portas. HAUTARZT 66:108-113(2015).
    Krabben, A; Huizinga, TWJ; et al. Biomarkers for Radiographic Progression in Rheumatoid Arthritis. CURRENT PHARMACEUTICAL DESIGN 21:147-169(2015).

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