• Official Full Name

    interleukin 4 receptor

  • Background

    This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.
  • Synonyms

    IL4R; interleukin 4 receptor; interleukin-4 receptor subunit alpha; CD124; IL-4 receptor subunit alpha; interleukin-4 receptor alpha chain; IL4RA; IL-4RA;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Cynomolgus
    • Cynomolgus monkey
    • Cynomolgus/Rhesus macaque
    • Human
    • Pig
    • Rat
    • Source :
    • A293 cells
    • CHO
    • E.coli
    • HEK293
    • HEK293 cells
    • Human Cell
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Yeast
    • Tag :
    • C
    • His
    • Fc
    • Avi
    • GST
    • His (Fc)
    • His|Avi
    • His|SUMOstar
    • human|IgG1|Fc
    • N/A
    • N
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Cynomolgus IL4R-18C Recombinant Cynomolgus IL4R protein, His-tagged HEK293 His
    Cynomolgus monkey IL4R-329C Recombinant Cynomolgus monkey IL4R Protein, His-tagged HEK293 His
    Cynomolgus monkey IL4R-330C Recombinant Cynomolgus monkey IL4R Protein, Fc-tagged HEK293 Fc
    Cynomolgus/Rhesus macaque IL4R-19C Recombinant Cynomolgus/Rhesus macaque IL4R protein, Fc-tagged HEK293 human/IgG1/Fc
    Human IL4R-588H Active Recombinant Human IL4R Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi
    Human IL4R-331H Recombinant Human IL4R Protein, His-tagged HEK293 His
    Human IL4R-068H Recombinant Human IL4R Protein, C-His-tagged E.coli C-His
    Human IL4R-5179H Recombinant Human IL4R Protein, GST-tagged Wheat Germ GST
    Human IL4R-2883H Recombinant Human IL4R protein, His-tagged E.coli His
    Human IL4R-28641TH Recombinant Human IL4R, Fc-tagged Fc
    Human IL4R-284H Recombinant Human Interleukin 4 Receptor, His-tagged Mammalian Cell His
    Human IL4R-2037H Recombinant Human IL4R Protein, His-tagged HEK293 His
    Human IL4R-2719HCL Recombinant Human IL4R cell lysate Human Cell N/A
    Human IL4R-5180H Recombinant Human IL4R Protein Wheat Germ N/A
    Human IL4R-587H Recombinant Human IL4R protein, His-tagged HEK293 His
    Human IL4R-01H Recombinant Human IL4R Protein CHO
    Human IL4R-1238H Recombinant Human Interleukin 4 Receptor A293 cells N/A
    Human IL4R-587HB Recombinant Human IL4R protein, His-tagged, Biotinylated HEK293 His
    Human IL4R-390H Recombinant Human IL4R protein, Fc-tagged HEK293 human/IgG1/Fc
    Human IL4R-301368H Recombinant Human IL4R protein, GST-tagged E.coli GST
    Human IL4R-586H Recombinant Human Interleukin 4 Receptor HEK293 N/A
    Human IL4R-051H Active Recombinant Human IL4R protein, Fc/Avi-tagged, Biotinylated HEK293 cells Fc/Avi
    Human IL4R-1645H Recombinant Human Interleukin 4 Receptor Mammalian cells N/A
    Human IL4R-2321H Recombinant Human IL4R Protein, His-tagged E.coli N-His
    Human IL4R-177I Recombinant Human IL4R Protein HEK293
    Human IL4R-4443H Recombinant Human IL4R Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human IL4R-4443H-B Recombinant Human IL4R Protein Pre-coupled Magnetic Beads HEK293
    Pig IL4R-2388P Recombinant Pig IL4R Protein (33-240 aa), His-tagged E.coli His
    Pig IL4R-2437P Recombinant Pig IL4R Protein (33-240 aa), His-sumostar-tagged Yeast His/SUMOstar
    Pig IL4R-5796P Recombinant Pig IL4R protein, His-tagged Yeast His
    Rat Il4r-2131R Recombinant Rat Il4r protein, His-tagged E.coli His
    Rat IL4R-1051RCL Recombinant Rat IL4R cell lysate Human Cell N/A
    Rat Il4r-379R Recombinant Rat Il4r, Fc tagged Human Cell Fc
    Rat Il4r-2198R Recombinant Rat Il4r protein, His-tagged HEK293 His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL4R Related Articles
    • IL4R Related Gene Family
    • IL4R Related Research Area

    IL4R involved in several pathways and played different roles in them. We selected most pathways IL4R participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL4R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionACVR1BA;IFNAR2;IL6;VEGFB;BMPR1BA;CCL15;CD40LG;CXCL14;CCR10
    PIK-Akt signaling pathwayGSK3B;PPP2CA;COL27A1;RAC1;EIF4E1B;IL3RA;FGF1;FGFR4;ATF4
    Jak-STAT signaling pathwayGHR;PRLR;IL28RA;GFAP;HRAS;AKT3A;IFNA16;IL-15RA;IRX1
    Hematopoietic cell lineageIL4;IL4R;CD3D;TNF;CD8B1;CD3G;HLA-DRB1;CSF3;CR1
    Inflammatory bowel disease (IBD)Il4ra;Il23a;TGFB3;IL12RB1;IFNG;STAT6;HLA-DQA1;IL23;FOXP3

    IL4R has several biochemical functions, for example, interleukin-4 receptor activity, protein binding, receptor signaling protein activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL4R itself. We selected most functions IL4R had, and list some proteins which have the same functions with IL4R. You can find most of the proteins on our site.

    Function Related Protein
    interleukin-4 receptor activity
    protein bindingSIL1;MYOC;LACTB2;RAPGEF4;FLVCR1;C22orf23;CALB1;MYH7B;CDK4
    receptor signaling protein activityTRAIP;RGS12B;CD3E;DOK4;RGS14;RAF1B;BAG4;IL1RL1;DOK1

    IL4R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL4R here. Most of them are supplied by our site. Hope this information will be useful for your research of IL4R.

    IL4; IL2RG; STAT6; IL13RA1

    Biedermann, T; Werfel, T; et al. Status quo and prospects for systemic therapy of atopic dermatitis. Biologics ante portas. HAUTARZT 66:108-113(2015).
    Krabben, A; Huizinga, TWJ; et al. Biomarkers for Radiographic Progression in Rheumatoid Arthritis. CURRENT PHARMACEUTICAL DESIGN 21:147-169(2015).
    • Q&As
    • Reviews

    Q&As (6)

    Ask a question
    How about function of IL4R? 10/15/2022

    IL4R is a synthetic protein that mimics the IL-4 signaling pathway in nature and binds to the IL-4 receptor in cells, which can be used to study the IL-4 signaling pathway and related diseases.

    What is the production technology of IL4R? 02/23/2022

    Common IL4R production technologies include prokaryotic expression systems and mammalian cell expression systems.

    Which application of IL4R in tumor therapy? 01/26/2022

    This protein is used in tumor immunotherapy, which can promote anti-tumor immune response and enhance the anti-tumor effect of cytotoxic T lymphocytes.

    In what fields does IL4R have applications? 07/09/2021

    It is mainly used in immunology, drug research and other fields. It is also widely used in vaccines, biotechnology, cancer treatment and so on.

    Are there have application of IL4R in the treatment of asthma? 03/23/2021

    IL4R is used to treat severe pheochromocytome-induced aerodoritis and was approved by the FDA as the first drug to treat this disease.

    Can IL4R be administered orally? 05/08/2020

    IL4R cannot generally be administered orally, and needs to be administered by injection or intravenous drip.

    Customer Reviews (3)

    Write a review

      In production, microorganisms such as Escherichia coli are often used as hosts for protein production, and there are often a large number of exogenous proteases and other background qualities in these host cells. Therefore, corresponding processing methods such as fusion of green fluorescent protein should be considered to avoid non-specific enzyme degradation of IL4R. -


        When producing IL4R, it is necessary to pay attention to the purity of the protein, and the separation technology such as chromatography and identification methods such as SDS-PAGE are usually used for accurate purity identification. -


          The biological function of IL4R, namely activity, is an important index to evaluate its quality, which can be identified by cell culture experiment, ELISA and other methods. -

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