IL4R
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Official Full Name
interleukin 4 receptor
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Overview
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. -
Synonyms
IL4R; interleukin 4 receptor; interleukin-4 receptor subunit alpha; CD124; IL-4 receptor subunit alpha; interleukin-4 receptor alpha chain; IL4RA; IL-4RA;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus
- Cynomolgus monkey
- Cynomolgus/Rhesus macaque
- Homo sapiens (Human)
- Human
- Mus musculus (Mouse)
- Pig
- Rat
- A293 cells
- CHO
- E.coli
- E.coli expression system
- HEK293
- HEK293 cells
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- Fc
- Avi
- GST
- His
- SUMO
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
IL4R involved in several pathways and played different roles in them. We selected most pathways IL4R participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL4R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | CXCR4B;TGFBR1A;KITLG;ACVR2B;GM13306;TNFRSF13B;NT5C3;CCR6A;IFNA10 |
| PIK-Akt signaling pathway | GYS2;TCL1B4;FGF11;PIK3CG;PRLR;PPP2R5D;FGF2;KRAS;FGFR4 |
| Jak-STAT signaling pathway | GM2002;IL27RA;IL12B;THPO;PIK3R3;Ifna15;IFNW1;IFNG;FHL1B |
| Hematopoietic cell lineage | IL1R1;KIT;CD24;HLA-DRA;HLA-DRB4;CD5;GP5;FLT3;CSF3R |
| Inflammatory bowel disease (IBD) | Il23a; Il12b;TLR4;IL18;IL5;IL17F;STAT6;IL23;IL21R;HLA-DOB |
IL4R has several biochemical functions, for example, interleukin-4 receptor activity, protein binding, receptor signaling protein activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL4R itself. We selected most functions IL4R had, and list some proteins which have the same functions with IL4R. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-4 receptor activity | |
| protein binding | ZUFSP;NETO2;CRYBA1;COMMD8;ETNK1;PPP2CA;NUB1;VAMP3;TTC19 |
| receptor signaling protein activity | DCLK1;DOK5;DOK4;RAF1B;TYROBP;cgr2b;KLK1B3;RGS12;FCAR |
IL4R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL4R here. Most of them are supplied by our site. Hope this information will be useful for your research of IL4R.
IL4; IL2RG; STAT6; IL13RA1
Gene Family
Research Area
Related articles
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewEasy to attach to the surface of cells or materials.
It has growth factor activity to promote cell growth and proliferation.
In animals or humans caused by the prone production of antibodies.
Q&As (6)
Ask a questionIL4R is a synthetic protein that mimics the IL-4 signaling pathway in nature and binds to the IL-4 receptor in cells, which can be used to study the IL-4 signaling pathway and related diseases.
Common IL4R production technologies include prokaryotic expression systems and mammalian cell expression systems.
This protein is used in tumor immunotherapy, which can promote anti-tumor immune response and enhance the anti-tumor effect of cytotoxic T lymphocytes.
It is mainly used in immunology, drug research and other fields. It is also widely used in vaccines, biotechnology, cancer treatment and so on.
IL4R is used to treat severe pheochromocytome-induced aerodoritis and was approved by the FDA as the first drug to treat this disease.
IL4R cannot generally be administered orally, and needs to be administered by injection or intravenous drip.
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