Recombinant Human IMPDH1 Protein, GST-tagged

• Cat.No.: IMPDH1-5140H
• Product Overview: Human IMPDH1 full-length ORF ( NP_899066.1, 1 a.a. - 563 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 86.8 kDa
• AA Sequence: MEGPLTPPPLQGGGAAAVPEPGARQ HPGHETAAQRYSARLLQAGYEPESM ADYLISGGTGYVPEDGLTAQQLFAS ADGLTYNDFLILPGFIDFIADEVDL TSALTRKITLKTPLISSPMDTVTEA DMAIAMALMGGIGFIHHNCTPEFQA NEVRKVKKFEQGFITDPVVLSPSHT VGDVLEAKMRHGFSGIPITETGTMG SKLVGIVTSRDIDFLAEKDHTTLLS EVMTPRIELVVAPAGVTLKEANEIL QRSKKGKLPIVNDCDELVAIIARTD LKKNRDYPLASKDSQKQLLCGAAVG TREDDKYRLDLLTQAGVDVIVLDSS QGNSVYQIAMVHYIKQKYPHLQVIG GNVVTAAQAKNLIDAGVDGLRVGMG CGSICITQEVMACGRPQGTAVYKVA EYARRFGVPIIADGGIQTVGHVVKA LALGASTVMMGSLLAATTEAPGEYF FSDGVRLKKYRGMGSLDAMEKSSSS QKRYFSEGDKVKIAQGVSGSIQDKG SIQKFVPYLIAGIQHGCQDIGARSL SVLRSMMYSGELKFEKRTMSAQIEG GVHGLHSYEKRLY
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: IMPDH1 IMP (inosine 5-monophosphate) dehydrogenase 1 [ Homo sapiens ]
• Official Symbol: IMPDH1
• Synonyms: IMPDH1; IMP (inosine 5-monophosphate) dehydrogenase 1; IMP (inosine monophosphate) dehydrogenase 1 , retinitis pigmentosa 10 (autosomal dominant) , RP10; inosine-5-monophosphate dehydrogenase 1; LCA11; sWSS2608; IMPD 1; IMPDH 1; IMPDH-I; IMP dehydrogenase 1; IMP (inosine monophosphate) dehydrogenase 1; IMPD; RP10; IMPD1; DKFZp781N0678
• Gene ID: 3614
• mRNA Refseq: NM_000883
• Protein Refseq: NP_000874
• MIM: 146690
• UniProt ID: P20839