Recombinant Human Insulin Receptor, Fc Chimera
Cat.No. : | INSR-611H |
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Source : | HEK293 |
Species : | Human |
Tag : | Fc |
Form : | PBS, pH 7.4 |
Protein length : | 1151 amino acids |
AA Sequence : | MDIRNNLTRLHELENCSVIEGHLQI LLMFKTRPEDFRDLSFPKLIMITDY LLLFRVYGLESLKDLFPNLTVIRGS RLFFNYALVIFEMVHLKELGLYNLM NITRGSVRIEKNNELCYLATIDWSR ILDSVEDNYIVLNKDDNEECGDICP GTAKGKTNCPATVINGQFVERCWTH SHCQKVCPTICKSHGCTAEGLCCHS ECLGNCSQPDDPTKCVACRNFYLDG RCVETCPPPYYHFQDWRCVNFSFCQ DLHHKCKNSRRQGCHQYVIHNNKCI PECPSGYTMNSSNLLCTPCLGPCPK VCHLLEGEKTIDSVTSAQELRGCTV INGSLIINIRGGNNLAAELEANLGL IEEISGYLKIRRSYALVSLSFFRKL RLIRGETLEIGNYSFYALDNQNLRQ LWDWSKHNLTITQGKLFFHYNPKLC LSEIHKMEEVSGTKGRQERNDIALK TNGDQASCENELLKFSYIRTSFDKI LLRWEPYWPPDFRDLLGFMLFYKEA PYQNVTEFDGQDACGSNSWTVVDID PPLRSNDPKSQNHPGWLMRGLKPWT QYAIFVKTLVTFSDERRTYGAKSDI IYVQTDATNPSVPLDPISVSNSSSQ IILKWKPPSDPNGNITHYLVFWERQ AEDSELFELDYCLKGLKLPSRTWSP PFESEDSQKHNQSEYEDSAGECCSC PKTDSQILKELEESSFRKTFEDYLH NVVFVPRKTSSGTGAEDPRPSRKRR SLGDVGNVTVAVPTVAAFPNTSSTS VPTSPEEHRPFEKVVNKESLVISGL RHFTGYRIELQACNQDTPEERCSVA AYVSARTMPEAKADDIVGPVTHEIF ENNVVHLMWQEPKEPNGLIVLYEVS YRRYGDEELHLCVSRKHFALERGCR LRGLSPGNYSVRIRATSLAGNGSWT EPTYFYVTDYLDVPSNIAKIEGRMD PKSSDKTHTCPPCPAPELLGGPSVF LFPPKPKDTLMISRTPEVTCVVVDV SHEDPEVKFNWYVDGVEVHNAKTKP REEQYNSTYRVVSVLTVLHQDWLNG KEYKCKVSNKALPAPIEKTISKAKG QPREPQVYTLPPSRDELTKNQVSLT CLVKGFYPSDIAVEWESNGQPENNY KTTPPVLDSDGSFFLYSKLTVDKSR WQQGNVFSCSVMHEALHNHYTQKSL SLSPGK |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >80% by SDS-PAGE |
Storage : | Store at -20 ~ -80 centigrade. Avoid repeated freeze-thaw cycles. |
Gene Name : | INSR insulin receptor [Homo sapiens] |
Official Symbol : | INSR |
Synonyms : | INSR; insulin receptor; HHF5; CD220; EC 2.7.10.1; IR; CD220 antigen; Insulin receptor subunit alpha; Insulin receptor subunit beta |
Gene ID : | 3643 |
mRNA Refseq : | NM_000208 |
Protein Refseq : | NP_000199 |
MIM : | 147670 |
UniProt ID : | P06213 |
Products Types
◆ Recombinant Protein | ||
INSR-5092H | Recombinant Human INSR Protein, GST-tagged | +Inquiry |
INSR-5093H | Active Recombinant Human INSR Protein, GST-tagged | +Inquiry |
INSR-0997H | Recombinant Human INSR Protein (M1-S1382), eGFP, Strep II, 10×His tagged | +Inquiry |
INSR-2566H | Recombinant Human INSR protein(601-750 aa), C-hFc & C-His-tagged | +Inquiry |
INSR-2565H | Recombinant Human INSR protein(601-940 aa), N-SUMO & C-His-tagged | +Inquiry |
◆ Lysates | ||
INSR-2648HCL | Recombinant Human INSR cell lysate | +Inquiry |
INSR-474HCL | Recombinant Human INSR cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1607 | INSR Internalization Assay Kit | +Inquiry |
Kit-1605 | U2OS INSR Bioassay Kit | +Inquiry |
Related Gene
Suppression of the Insulin Receptors in Adult Schistosoma japonicum Impacts on Parasite Growth and Development: Further Evidence of Vaccine Potential
Journal: PLoS Neglected Tropical Diseases PubMed ID: 25961574 Data: 2015/5/11
Authors: Hong You, Geoffrey N. Gobert, Mark Pearson
Article Snippet:Recombinant human insulin receptor (HIR) (short isoform) extracellular domain (Met1-Lys 956) (Creative BioMart, Inc., USA) and recombinant SjLD1 and SjLD2 (expressed in E . coli ) [ ] (see below) were subjected to electrophoresis on 12% (w/v) SDS-PAGE gels (1μg in 10μl SDS-PAGE sample buffer) as described above and then blotted onto a nitrocellulose membrane.. Rabbit anti-HIR polyclonal antibody (1:300) (Creative BioMart, Inc, Shirley, NY, USA), produced in a rabbit immunized with purified human cell-derived recombinant HIR extracellular domain (Met1-Lys 956), and the rabbit anti-SjLD1 (1:50) and anti-SjLD2 (1:50) sera were used as primary antibodies.Rabbit anti-HIR polyclonal antibody (1:300) (Creative BioMart, Inc, Shirley, NY, USA), produced in a rabbit immunized with purified human cell-derived recombinant HIR extracellular domain (Met1-Lys 956), and the rabbit anti-SjLD1 (1:50) and anti-SjLD2 (1:50) sera were used as primary antibodies.
Results are shown for proteins recognised by anti-Sm-Pmy antibody (top panel), anti-SjLD1 (middle panel) and anti-SjLD2 (bottom panel) antibodies. The intensity of Sm-Pmy expression was evaluated so as to determine equal protein loading. The arrows indicate the diminished level of SjIR proteins relative to the luciferase treatment control in the first lane. The experiment was repeated twice with similar results obtained. B . Western blot analysis showing no immunological cross reactivity between recombinant
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewThe compatibility with a range of lab equipment streamlined experimental procedures, saving both time and effort.
The product's support in the form of educational resources positively impacted the learning curve for our researchers.
The proactive engagement with customer insights contributed to the product's ongoing relevance in the scientific community.
Q&As (7)
Ask a questionMalfunction or dysregulation of the insulin receptor (INSR) can lead to disturbances in metabolic health, contributing to conditions like diabetes.
INSR regulates glucose metabolism by facilitating the cellular uptake of glucose in response to insulin.
The insulin receptor (INSR) is prominently expressed in tissues such as the liver, muscle, and adipose tissue.
Genetic variations or mutations in the insulin receptor (INSR) are associated with certain metabolic disorders and insulin resistance.
In diabetes, the insulin receptor (INSR) contributes to the development of insulin resistance, impairing its normal signaling functions.
The insulin receptor (INSR) protein plays a crucial role in cellular processes, particularly in mediating the effects of insulin.
Upon insulin binding, the insulin receptor (INSR) activates downstream signaling pathways, including the PI3K-AKT pathway.
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