INSR

  • Official Full Name

    Insulin Receptor

  • Overview

    This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. Mediates the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). Can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.
  • Synonyms

    CD220; CD220 antigen; HHF 5; INSR; INSR_HUMAN; Insulin receptor subunit beta; IR; Insulin Receptor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Crab-eating macaque
  • Homo sapiens (Human)
  • Human
  • Human
  • Monkey
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus monkey
  • E.coli
  • E.coli expression system
  • HEK293
  • Human Cell
  • Insect Cell
  • Mammalian cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • hFc
  • His
  • DDK|His
  • eGFP,Strep II,10His
  • Fc
  • GST
  • hIgG1
  • hIgG4
  • His (Fc)
  • Avi
  • His|GST
  • His|SUMO
  • N/A
  • N
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human INSR-294H Active Recombinant Human INSR Protein, His & GST-tagged Insect Cell His/GST
Human INSR-1416H Active Recombinant Human InsR, GST-tagged Sf9 Insect Cell GST 1011 aa-end
Human INSR-661H Active Recombinant Human INSR, His-tagged Mammalian cells His
Human INSR-108H Activated Recombinant Human INSR(1005-1310) Protein, N-His-tagged Sf21 His 1005-1310 aa
Human INSR-109H Active Recombinant Human INSR(1005-1311) Protein, N-His-tagged Sf21 His 1005-1310 aa
Human INSR-623H Recombinant Human INSR, His tagged HEK293 His Met 1-Lys 956
Human INSR-27625TH Recombinant Human INSR N/A
Human INSR-29493TH Recombinant Human INSR N/A
Human INSR-7894H Recombinant Human INSR protein, His-tagged E.coli His Pro622~Thr945 (Accession # P06213)
Human INSR-622H Recombinant Human INSR, His tagged HEK293 His Met 1-Lys 944
Human INSR-1260H Recombinant Human INSR Protein, His-SUMO-tagged E.coli His/SUMO
Human INSR-611H Recombinant Human Insulin Receptor, Fc Chimera HEK293 Fc 1151 amino acids
Human INSR-216H Recombinant Human INSR protein, DDK/His-tagged HEK293 DDK/His
Human INSR-331H Recombinant Human Insulin Receptor, GST-tagged, Active Sf9 Insect Cell GST
Human INSR-7893H Recombinant Human INSR protein, His-tagged E.coli His Thr1024~Phe1298
Human INSR-2648HCL Recombinant Human INSR cell lysate Human Cell N/A
Human INSR-474HCL Recombinant Human INSR cell lysate Insect Cell N/A
Human INSR-1220H Recombinant Human INSR Protein (Ser763-Lys956), N-His tagged E.coli N-His Ser763-Lys956
Human INSR-5093H Active Recombinant Human INSR Protein, GST-tagged Insect Cell GST
Human INSR-2565H Recombinant Human INSR protein(601-940 aa), N-SUMO & C-His-tagged E.coli N-SUMO & C-His 601-940 aa
Human INSR-29H Recombinant Human INSR protein, His-tagged HEK293 His His28-Lys944
Human INSR-5092H Recombinant Human INSR Protein, GST-tagged Wheat Germ GST
Human INSR-0997H Recombinant Human INSR Protein (M1-S1382), eGFP, Strep II, 10×His tagged Mammalian cell eGFP,Strep II,10His M1-S1382
Human INSR-497H Active Recombinant Human INSR Protein (Long Isoform) (Met1-Lys956), His-tagged, Biotinylated HEK293 His Met1-Lys956
Human INSR-4313H Recombinant Human INSR Protein (Met1-Ser758), C-His tagged Mammalian cells C-His Met1-Ser758
Human INSR-3163H Recombinant Human INSR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human INSR-2564H Recombinant Human INSR protein(601-750 aa), C-His-tagged E.coli C-His 601-750 aa
Human INSR-3163H-B Recombinant Human INSR Protein Pre-coupled Magnetic Beads HEK293
Human INSR-2566H Recombinant Human INSR protein(601-750 aa), C-hFc & C-His-tagged HEK293 C-hFc & C-His 601-750 aa
Mouse INSR-8242M Recombinant Mouse INSR Protein Mammalian Cell His
Mouse Insr-7895M Recombinant Mouse Insr protein, His-tagged E.coli His Leu1101~Ser1372 (Accession # P15208)
Mouse INSR-4564M Recombinant Mouse INSR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse INSR-4564M-B Recombinant Mouse INSR Protein Pre-coupled Magnetic Beads HEK293
Rat Insr-7896R Recombinant Rat Insr protein, His-tagged E.coli His Ser1114~Pro1382 (Accession # P15127)
Monkey INSR-1605R Recombinant Monkey INSR Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey INSR-1606R Recombinant Rhesus Monkey INSR Protein, hIgG4-tagged HEK293 hIgG4
Rhesus monkey INSR-1604R Recombinant Rhesus Monkey INSR Protein HEK293 N/A
Crab-eating macaque INSR-1605C Recombinant Crab-eating Macaque INSR Protein, Fc-tagged HEK293 Fc 32-956
Homo sapiens (Human) RFL3292HF Recombinant Full Length Human Insulin Receptor(Insr) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (28-758)
Mus musculus (Mouse) RFL36502MF Recombinant Full Length Mouse Insulin Receptor(Insr) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (28-748)
Rattus norvegicus (Rat) RFL30439RF Recombinant Full Length Rat Insulin Receptor(Insr) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (27-759)
Kit-1607 INSR Internalization Assay Kit N/A
Kit-1605 U2OS INSR Bioassay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

INSR involved in several pathways and played different roles in them. We selected most pathways INSR participated on our site, such as Ras signaling pathway, Rap signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with INSR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ras signaling pathwayGRIN2B;FGF2;GNG8;INSR;FGFR4;FGF18;ETS1;PLA2G3;PLA2G12B
Rap signaling pathwayINS2;FGF7;PIK3R3;CALM3;F2R;PRKD3;Kitl;VASP;ID1
cGMP-PKG signaling pathwayATP2B4;CALM1;ATP1B2;PRKCE;GUCY1A3;PIK3R1;PPP1CA;ATP1B3;PIK3CA
HIF- signaling pathwayPIK3CA;STAT3;TCEB2;EP300;MAP2K2;PLCG1;INS2;CAMK2A;EIF4E2
FoxO signaling pathwayCCND1;STK4;SMAD3;AGAP2;PRKAA1;PTENA;CAT;TGFBR2;MAPK9
Phospholipase D signaling pathwayLPAR5;LPAR2;GRM7;TSC2;INS2;SHC2;AGTR1A;CYTH2;PLCG1
PIK-Akt signaling pathwayVTN;FGF16;FGF18;KIT;PRLR;IL2RG;CCND1;YWHAE;LAMB1
AMPK signaling pathwayPRKAA2;PRKAB1;MLYCD;PPP2R5D;CCNA2;CREB3L2;Scd1;ELAVL1;CREB1
Adherens junctionWASLB;ACTB2;CTNNA1;FGFR1;CSNK2A2A;RAC3B;NLK;WASB;CTNND1
Insulin signaling pathwayPIK3CA;PRKCZ;PYGL;PPP1CBL;PHKG1;PPP1CB;PHKA2;PHKG1A;PIK3CD
Ovarian steroidogenesisIGF1R;HSD17B2;SCARB1;ALOX5;ACOT2;GDF9;GNAS;LHB;PRKACG
Regulation of lipolysis in adipocytesPRKG1;INSR;FABP4;PNPLA2;PLIN1;TSHR;NPR1;PIK3CA;PRKACA
Type II diabetes mellitusPIK3CD;INS-IGF2;PRKCD;MAPK9;MAPK3;PIK3CB;MTOR;SOCS1;HK1
Insulin resistancePRKAA2;IRS1;PRKCD;PRKCBA;IKBKB;CREB3L3A;PPP1R3B;SOCS3B;PCK1
Non-alcoholic fatty liver disease (NAFLD)RAC1;PIK3CD;PIK3CA;NDUFA10;NDUFA11;RELA;BAX;NDUFA4;COX7B2
Aldosterone-regulated sodium reabsorptionKCNJ1;ALPHA-ENAC;PDPK1;INS2;ATP1A2;INS1;PRKCB;INS;PIK3CG

INSR has several biochemical functions, for example, ATP binding, GTP binding, PTB domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INSR itself. We selected most functions INSR had, and list some proteins which have the same functions with INSR. You can find most of the proteins on our site.

Function Related Protein
ATP bindingLMTK2;ROCK2;SRX1;DYNC1LI1;LONP1;EIF2AK1;NUBPL;PTK2;CDK19
GTP bindingRHOV;TUBA8L3;TUBG1;MXA;AK4;SEPT2;RAB5C;DNM3A;ARL15
PTB domain bindingINSR;NUP62;APP;INPP5D
insulin bindingINSR;C2CD2L;HSPD1;IDE;PIK3R1;IGF1R
insulin receptor substrate bindingIGF1R;PIK3R1;IGF1RA;PRKCD;INSR;GRB2;PRKCZ;PIK3CA;IGF1RB
insulin-activated receptor activity
insulin-like growth factor I bindingINSR;IGFBP5B;IGFBP6A;IGF1R;IGFBP5A;IGFBP6B;IGFBP1B;IGFBP5;IGFBP2B
insulin-like growth factor II bindingIGFBP2;IGFBP2B;INSR;IGFBP5;IGFBP5B;IGFBP6A;IGFBP3;IGFBP1B;IGFBP6
insulin-like growth factor receptor bindingRen1;INS2;GNAS;YWHAG;IRS1;INS;SHC1;INSR;IGF3
phosphatidylinositol 3-kinase bindingCORO1A;CALM3;PDGFRB;DAB1;INSRR;TYRO3;LCK;INSRA;INSR
protein bindingSELENBP1;ANKHD1;NPEPL1;MED19;TSN;ECSIT;FERD3L;DNAJC19;DNAJA2
protein tyrosine kinase activityERBB3B;YES1;SHC1;DYRK4;FYNB;ROS1;MET;BAZ1B;JAK2
receptor signaling protein tyrosine kinase activityLYN;TYRO3;SYK;ERBB3B;KITB;INSR;ERBB4A;KIT;EGFR

INSR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INSR here. Most of them are supplied by our site. Hope this information will be useful for your research of INSR.

PTPN1

Research Area

Related articles

Besic, V; Shi, HJ; et al. Aberrant Liver Insulin Receptor Isoform A Expression Normalises with Remission of Type 2 Diabetes after Gastric Bypass Surgery. PLOS ONE 10:-(2015).
McAllister, JM; Legro, RS; et al. Functional genomics of PCOS: from GWAS to molecular mechanisms. TRENDS IN ENDOCRINOLOGY AND METABOLISM 26:118-124(2015).
  • Q&As
  • Reviews

Q&As (7)

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What impact does malfunction or dysregulation of the insulin receptor (INSR) have on metabolic health? 10/31/2020

Malfunction or dysregulation of the insulin receptor (INSR) can lead to disturbances in metabolic health, contributing to conditions like diabetes.

How does the insulin receptor (INSR) function in regulating glucose metabolism in cells? 04/08/2020

INSR regulates glucose metabolism by facilitating the cellular uptake of glucose in response to insulin.

What are the key tissues or cell types where the insulin receptor (INSR) is prominently expressed? 08/29/2019

The insulin receptor (INSR) is prominently expressed in tissues such as the liver, muscle, and adipose tissue.

Are there known genetic variations or mutations in the insulin receptor (INSR) associated with metabolic disorders or insulin resistance? 02/27/2019

Genetic variations or mutations in the insulin receptor (INSR) are associated with certain metabolic disorders and insulin resistance.

In the context of diabetes, what role does the insulin receptor (INSR) play in the development of insulin resistance? 06/16/2018

In diabetes, the insulin receptor (INSR) contributes to the development of insulin resistance, impairing its normal signaling functions.

What is the primary role of the insulin receptor (INSR) protein in cellular processes? 04/29/2017

The insulin receptor (INSR) protein plays a crucial role in cellular processes, particularly in mediating the effects of insulin.

How does the insulin receptor (INSR) activate downstream signaling pathways in response to insulin binding? 09/14/2016

Upon insulin binding, the insulin receptor (INSR) activates downstream signaling pathways, including the PI3K-AKT pathway.

Customer Reviews (3)

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Reviews
02/25/2020

    The compatibility with a range of lab equipment streamlined experimental procedures, saving both time and effort.

    04/26/2016

      The product's support in the form of educational resources positively impacted the learning curve for our researchers.

      04/18/2016

        The proactive engagement with customer insights contributed to the product's ongoing relevance in the scientific community.

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