INSR
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Official Full Name
Insulin Receptor -
Overview
This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. Mediates the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). Can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. -
Synonyms
CD220;CD220 antigen;HHF 5;INSR;INSR_HUMAN;Insulin receptor subunit beta;IR;Insulin Receptor
Recombinant Proteins
- Human
- Rhesus macaque
- Monkey
- Mouse
- Rat
- Crab-eating macaque
- Mus musculus
- HEK293
- Sf9 Cells
- Insect Cells
- Mammalian Cells
- E.coli
- Human Cells
- Wheat Germ
- His
- GST
- SUMO
- Non
- Fc
- hIgG4
- Flag
- Avi
Involved Pathway
INSR involved in several pathways and played different roles in them. We selected most pathways INSR participated on our site, such as Ras signaling pathway,Rap signaling pathway,cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with INSR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of lipolysis in adipocytes | PRKG2,TSHB,TSHR,GNAI2,PLIN1,NPR1,NPY,IRS2,INS1,PRKACG |
| FoxO signaling pathway | PRKAB1B,MAPK12,IL7R,PRMT1,MAPK1,BRAF,PDPK1,SGK1,BCL6A,CCND2A |
| cGMP-PKG signaling pathway | ATP1B1,AGTR1A,NFATC2,RAF1,SRF,ATP1A4,ROCK1,SLC25A31,MEF2C,GUCY1B3 |
| Adherens junction | NLK2,RAC3B,SMAD3A,CTNNB1,TGFBR1A,CSNK2B,TCF7L2,PVRL1,ERBB2,CTNNA1 |
| Ovarian steroidogenesis | HSD3B4,LDLR,AKR1C3,INS,SCARB1,PRKACG,BMP15,PLA2G4D,Adcy4,ACOT2 |
| Type II diabetes mellitus | MAFA,INS2,HKDC1,IRS4,MAPK3,ADIPOQ,INS-IGF2,PKM,PIK3R2,SOCS1 |
| Rap signaling pathway | LPAR3,KITLG,GNAI3,Pdgfa&Pdgfb,MAP2K2,ARAP3,PRKD1,GNAQ,VASP,VEGFC |
| Insulin signaling pathway | PIK3R3B,PPP1R3CA,INSRB,RAF1A,EIF4E2,PPP1R3A,IRS4,PPP1CAB,EXOC7,PYGL |
| Ras signaling pathway | SHC1,PLA2G4C,PRKACA,KSR2,FGF16,PLA2G2E,FOXO4,SOS1,MAPK3,CALM3 |
Protein Function
INSR has several biochemical functions, for example, ATP binding,GTP binding,PTB domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INSR itself. We selected most functions INSR had, and list some proteins which have the same functions with INSR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| insulin receptor substrate binding | INSRB,PTPN11,IGF1R,INSRA,PIK3R1,PRKCZ,INSRR,PRKCD,IGF1RB,IGF1RA |
| receptor signaling protein tyrosine kinase activity | KITA,ERBB4,EGFR,SYK,TYRO3,KITB,KIT,EGFRA,ERBB3B,LYN |
| protein tyrosine kinase activity | EPHA4B,TTK,MUSK,FGFR4,BTK,SRMS,MATK,PTK2AB,EPHB3A,IGF1RB |
| insulin-like growth factor II binding | IGFBP6,IGFBP1B,IGFBP6B,IGFBP6A,IGFBP2B,IGFBP5B,IGFBP1A,IGFBP3,IGFBP5A,IGFBP4 |
| protein binding | SCYL1,TUBB2B,CDK16,CRIPT,GP1BB,CBFA2T2,VPS25,MT1H,CYTH3,DR1 |
| PTB domain binding | APP,NUP62,INPP5D |
| ATP binding | ITPKC,CASK,SUCLA2,DDX5,CDK15,CKMT2B,SCYL3,TWF2,DHX35,MYO3A |
| insulin-like growth factor I binding | IGFBP5B,IGFBP2B,IGFBP3,IGFBP5A,IGFBP2,IGF1R,IGFBP6B,IGFBP6A,IGFBP6,IGFBP1A |
| phosphatidylinositol 3-kinase binding | INSRA,IRS2,BECN1,ATP1A1,CORO1A,INSRB,PDGFRB,IGF1RA,IRS4,CALM3 |
Interacting Protein
INSR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INSR here. Most of them are supplied by our site. Hope this information will be useful for your research of INSR.
PTPN1
Resources
Research Area
- Endocrine Regulation of Lipid Metabolism
- Cytokine and Growth Factor Receptors on VSMC
- Peptide Receptors on VSMC
- Other CD Antigen
- Receptor Tyrosine Kinases (RTKs)
- Receptor Tyrosine Kinases (RTKs) in the Akt Pathway
- Growth Hormone/IGF-I Axis
- Negative Regulators of the Jak/STAT Pathway
- Receptors in the Jak/STAT Pathway
- IGF Receptor
Related Services
Related Products
References
- Besic, V; Shi, HJ; et al. Aberrant Liver Insulin Receptor Isoform A Expression Normalises with Remission of Type 2 Diabetes after Gastric Bypass Surgery. PLOS ONE 10:-(2015).
- McAllister, JM; Legro, RS; et al. Functional genomics of PCOS: from GWAS to molecular mechanisms. TRENDS IN ENDOCRINOLOGY AND METABOLISM 26:118-124(2015).
