INSR
-
Official Full Name
Insulin Receptor
-
Overview
This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. Mediates the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). Can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. -
Synonyms
CD220; CD220 antigen; HHF 5; INSR; INSR_HUMAN; Insulin receptor subunit beta; IR; Insulin Receptor;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Crab-eating macaque
- Homo sapiens (Human)
- Human
- Human
- Monkey
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Rhesus monkey
- E.coli
- E.coli expression system
- HEK293
- Human Cell
- Insect Cell
- Mammalian cell
- Mammalian Cell
- Mammalian cells
- Sf21
- Sf9 Insect Cell
- Wheat Germ
- C
- hFc
- His
- Fc
- GST
- hIgG4
- Avi
- Flag
- StrepII
- EGFP
- SUMO
- Non
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
INSR involved in several pathways and played different roles in them. We selected most pathways INSR participated on our site, such as Ras signaling pathway, Rap signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with INSR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | GNG13;GNG12;AKT2;IGF1R;FGF19;PAK7;GNB2;PLA2G4F;ETS2 |
| Rap signaling pathway | PRKCB;CALML3;PDGFRB;LAT;PLCB1;TLN1;PGF;PDGFRA;PRKCI |
| cGMP-PKG signaling pathway | NFATC2;PLCB4;PIK3CD;ATP1B1;PIK3CA;GTF2IRD1;MAP2K2;CREB5;PIK3R2 |
| HIF- signaling pathway | VHL;GM5506;NOS2;EIF4E1B;NOS3;RBX1;ENO3;EGLN1;PDHA1 |
| FoxO signaling pathway | MAPK14A;ARAF;PIK3R3A;FOXO1;IGF1RB;GRB2;MAPK8B;MAP2K1;HRASA |
| Phospholipase D signaling pathway | DGKE;CXCR1;PDGFD;AKT2;PLCG1;INS1;MAP2K1;GRM8;PLCB2 |
| PIK-Akt signaling pathway | IFNA4;GH1;ITGB4;FGF16;ITGA3;LAMA2;THBS4;PPP2R5D;FGFR2 |
| AMPK signaling pathway | CAB39L;PIK3R1;CREB3L4;CREB3L1;PIK3CB;RAB10;PIK3R3;EEF2K;PPP2R1A |
| Adherens junction | WASF1;MAP3K7;PVRL3B;FYN;MLLT4;IGF1R;ACTN3;PVRL1B;PTBP3 |
| Insulin signaling pathway | MKNK1;PHKB;INPP5K;MAPK1;PRKACG;FLOT1;FBP1;MKNK2B;TSC1A |
| Ovarian steroidogenesis | SCARB1;BMP6;HSD3B1;HSD3B6;AKR1C3;FSHB;BMP15;HSD3B5;HSD3B4 |
| Regulation of lipolysis in adipocytes | AQP7;Adcy4;PTGS1;PDE3B;TSHR;IRS2;INS;PIK3R2;PIK3CD |
| Type II diabetes mellitus | IKBKB;SOCS1;PIK3R5;ADIPOQ;PIK3CB;CACNA1G;PIK3CD;INS2;MAPK3 |
| Insulin resistance | PIK3CB;RPS6KB1;PTPRFB;PPP1R3A;PTENB;RPS6KA6;G6PC;IKBKB;PIK3R3 |
| Non-alcoholic fatty liver disease (NAFLD) | SDHB;NDUFA4;SREBF1;ERN1;NDUFA4L2;NDUFA7;INSR;CDC42;NDUFA1 |
| Aldosterone-regulated sodium reabsorption | PRKCB;SGK1;MAPK3;FXYD2;PIK3R2;KCNJ1;KRAS;PIK3CA;PRKCG |
INSR has several biochemical functions, for example, ATP binding, GTP binding, PTB domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INSR itself. We selected most functions INSR had, and list some proteins which have the same functions with INSR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | SGK2A;NLRC3;CKMT1;SUCLG2;NME1;MCM8;ROCK2;EPHB2;MAPK1 |
| GTP binding | RAB25B;RTKN;ARF4;SEPT1;GIMAP3;RNGTT;SEPT8A;RALBB;REM2 |
| PTB domain binding | APP;INPP5D;NUP62;INSR |
| insulin binding | HSPD1;PIK3R1;C2CD2L;IDE;INSR;IGF1R |
| insulin receptor substrate binding | INSRR;PRKCD;IGF1RB;PIK3CB;IGF1R;INSRA;INSRB;PIK3CA;GRB2 |
| insulin-activated receptor activity | |
| insulin-like growth factor I binding | IGFBP2B;IGFBP6A;IGF1R;IGFBP5B;IGFBP4;IGFBP2;IGFBP5A;IGFBP5;IGFBP1B |
| insulin-like growth factor II binding | IGFBP5B;IGFBP4;IGFBP2;INSR;IGFBP2B;IGFBP6A;IGFBP5;IGFBP6B;IGFBP1B |
| insulin-like growth factor receptor binding | INS2;Ren1;YWHAH;SHC1;IGF3;YWHAG;PIK3R1;IRS1;SOCS2 |
| phosphatidylinositol 3-kinase binding | HCST;FLT3;ATP1A1;IRS2;CALM2;BECN1;PDGFRB;DAB1;IRS4 |
| protein binding | DYDC1;KIF6;ANGPT1;SLC25A6;KRTAP13-3;PRCC;MIB1;ERCC6;TLR6 |
| protein tyrosine kinase activity | JAK3;AXL;TNK2;MUSK;CLK4;PTK7;MAP2K6;DYRK1B;EPHB4A |
| receptor signaling protein tyrosine kinase activity | TYRO3;SYK;ERBB4;KITB;ERBB3B;ERBB4A;EGFR;ERBB2;INSR |
INSR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INSR here. Most of them are supplied by our site. Hope this information will be useful for your research of INSR.
PTPN1
Research Area
Related articles
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewThe compatibility with a range of lab equipment streamlined experimental procedures, saving both time and effort.
The product's support in the form of educational resources positively impacted the learning curve for our researchers.
The proactive engagement with customer insights contributed to the product's ongoing relevance in the scientific community.
Q&As (7)
Ask a questionMalfunction or dysregulation of the insulin receptor (INSR) can lead to disturbances in metabolic health, contributing to conditions like diabetes.
INSR regulates glucose metabolism by facilitating the cellular uptake of glucose in response to insulin.
The insulin receptor (INSR) is prominently expressed in tissues such as the liver, muscle, and adipose tissue.
Genetic variations or mutations in the insulin receptor (INSR) are associated with certain metabolic disorders and insulin resistance.
In diabetes, the insulin receptor (INSR) contributes to the development of insulin resistance, impairing its normal signaling functions.
The insulin receptor (INSR) protein plays a crucial role in cellular processes, particularly in mediating the effects of insulin.
Upon insulin binding, the insulin receptor (INSR) activates downstream signaling pathways, including the PI3K-AKT pathway.
Ask a Question for All INSR Products
Required fields are marked with *
My Review for All INSR Products
Required fields are marked with *
