Recombinant Human Interleukin 11

Cat.No. : IL11-551H
Product Overview : Recombinant HumanIL11 is a single, non-glycosylated polypeptide chain containing 178 aminoacids. IL11 is expressed in E. coli, MW 19.1 kDa.
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Cat. No. : IL11-551H
Description : Interleukin 11 (IL11)is a protein that in humans is encoded by the IL11 gene. IL11 is amultifunctional cytokine first isolated in 1990 from bone marrow-derivedstromal cells. It is a key regulator of multiple events in hematopoiesis,most notably the stimulation of megakaryocyte maturation.It is also knownunder the names adipogenesis.
Source : Human
Host : E. coli
Form : Lyophilizedfrom a 0.2μm filtered concentrated solution in PBS, pH 7.4.
Purity : >97% asdetermined by HPLC and SDS-PAGE analyses.
Molecular Weight : 19.1 kDa
Biological Activity : The ED50as determined by the dose-dependant stimulation of the proliferation ofmurineB9-11 was found to be less than 1 ng/ml, corresponding to a specificactivity of 1 x 10⁷ IU/mg.
Endotoxin Level : Less than0.1 ng/µg (1 EU/µg) of recombinant human IL11.
Reconstitution : Centrifugevial prior to opening. Add sterile distilled water or aqueous buffer to a concentrationof 0.1-1.0 mg/mL. Further dilutions should be made in appropriate bufferedsolutions.
Storage : Stableat 2-8°C, but best kept desiccated -20°C. Upon reconstitution, stable for upto 1 week at 2-8°C. For longer term, store in working aliquots below -20°C.Avoid repeated freeze/thaw cycles.
OfficialSymbol : IL11
Gene Name : IL11 interleukin 11 [ Homosapiens ]
Synonyms : IL11; interleukin 11; AGIF; IL-11; interleukin-11; Oprelvekin;oprelvekin; adipogenesis inhibitory factor; Adipogenesis inhibitory factor
Gene ID : 3589
mRNA Refseq : NM_000641
Protein Refseq : NP_000632
MIM : 147681
UniProt ID : P20809
Chromosome Location : 19q13.3-q13.4
Pathway : Cytokine-cytokinereceptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway;Rheumatoid arthritis
Function : cytokineactivity; growth factor activity; interleukin-11 receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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Q&As (10)

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How are in vivo models, including transgenic mice and knockdown strategies, utilized to study IL11's effects on tissue regeneration and homeostasis? 11/05/2022

Transgenic mice and knockdown models explore IL11's impact on tissue regeneration.

Could you explain the experimental approaches, such as site-directed mutagenesis, employed to identify key residues in IL11's interaction with IL11RA? 07/14/2021

Site-directed mutagenesis identifies key residues in IL11's interaction with IL11RA.

What techniques like chromatin immunoprecipitation and DNA methylation analysis contribute to deciphering IL11's regulatory mechanisms? 05/27/2021

Chromatin immunoprecipitation and DNA methylation analysis decipher IL11's regulatory mechanisms.

Can you elaborate on the role of proteomics in identifying IL11-interacting proteins and potential cross-talk with other signaling pathways? 09/28/2020

Proteomics identifies IL11-interacting proteins and potential cross-talk partners.

How do cell-based assays and luciferase reporter assays help investigate IL11's downstream signaling pathways through JAK-STAT activation? 05/19/2020

Cell-based and luciferase reporter assays elucidate IL11's JAK-STAT signaling activation.

What role does RNA sequencing play in understanding IL11-induced gene expression changes in various cell types? 02/24/2019

RNA sequencing uncovers IL11-induced gene expression changes across different cell types.

What structural insights have X-ray crystallography and nuclear magnetic resonance spectroscopy provided about the IL11-IL11RA complex? 01/13/2019

X-ray crystallography and NMR spectroscopy reveal structural details of the IL11-IL11RA complex.

How do advanced imaging techniques like confocal microscopy and super-resolution microscopy visualize IL11 localization and distribution in tissues? 11/08/2018

Confocal and super-resolution microscopy visualize IL11 localization in tissues.

How are techniques like surface plasmon resonance used to study IL11's binding kinetics to its receptor IL11RA? 04/17/2017

Techniques like surface plasmon resonance measure IL11-IL11RA binding affinity and kinetics.

What insights have CRISPR screening approaches provided regarding genes and pathways influenced by IL11 signaling? 02/06/2017

CRISPR screening unveils genes and pathways influenced by IL11 signaling.

Customer Reviews (3)

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    Potent in bone regeneration models. -


      Suitable for cell culture. -


        High yield in expression. -

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