Recombinant Human Interleukin 11
|Product Overview :||Recombinant HumanIL11 is a single, non-glycosylated polypeptide chain containing 178 aminoacids. IL11 is expressed in E. coli, MW 19.1 kDa.|
- Gene Information
- Related Products
|Cat. No. :||IL11-551H|
|Description :||Interleukin 11 (IL11)is a protein that in humans is encoded by the IL11 gene. IL11 is amultifunctional cytokine first isolated in 1990 from bone marrow-derivedstromal cells. It is a key regulator of multiple events in hematopoiesis,most notably the stimulation of megakaryocyte maturation.It is also knownunder the names adipogenesis.|
|Host :||E. coli|
|Form :||Lyophilizedfrom a 0.2μm filtered concentrated solution in PBS, pH 7.4.|
|Purity :||>97% asdetermined by HPLC and SDS-PAGE analyses.|
|Sequence :||PGPPPGPPR VSPDPRAELDSTVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQWLRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGGLHLTLDWAVR GLLLLKTRL|
|Molecular Weight :||19.1 kDa|
|Biological Activity :||The ED50as determined by the dose-dependant stimulation of the proliferation ofmurineB9-11 was found to be less than 1 ng/ml, corresponding to a specificactivity of 1 x 10⁷ IU/mg.|
|Endotoxin Level :||Less than0.1 ng/µg (1 EU/µg) of recombinant human IL11.|
|Reconstitution :||Centrifugevial prior to opening. Add sterile distilled water or aqueous buffer to a concentrationof 0.1-1.0 mg/mL. Further dilutions should be made in appropriate bufferedsolutions.|
|Storage :||Stableat 2-8°C, but best kept desiccated -20°C. Upon reconstitution, stable for upto 1 week at 2-8°C. For longer term, store in working aliquots below -20°C.Avoid repeated freeze/thaw cycles.|
|Gene Name :||IL11 interleukin 11 [ Homosapiens ]|
|Synonyms :||IL11; interleukin 11; AGIF; IL-11; interleukin-11; Oprelvekin;oprelvekin; adipogenesis inhibitory factor; Adipogenesis inhibitory factor|
|Gene ID :||3589|
|mRNA Refseq :||NM_000641|
|Protein Refseq :||NP_000632|
|UniProt ID :||P20809|
|Chromosome Location :||19q13.3-q13.4|
|Pathway :||Cytokine-cytokinereceptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway;Rheumatoid arthritis|
|Function :||cytokineactivity; growth factor activity; interleukin-11 receptor binding|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
Transgenic mice and knockdown models explore IL11's impact on tissue regeneration.
Site-directed mutagenesis identifies key residues in IL11's interaction with IL11RA.
Chromatin immunoprecipitation and DNA methylation analysis decipher IL11's regulatory mechanisms.
Proteomics identifies IL11-interacting proteins and potential cross-talk partners.
Cell-based and luciferase reporter assays elucidate IL11's JAK-STAT signaling activation.
RNA sequencing uncovers IL11-induced gene expression changes across different cell types.
X-ray crystallography and NMR spectroscopy reveal structural details of the IL11-IL11RA complex.
Confocal and super-resolution microscopy visualize IL11 localization in tissues.
Techniques like surface plasmon resonance measure IL11-IL11RA binding affinity and kinetics.
CRISPR screening unveils genes and pathways influenced by IL11 signaling.
Customer Reviews (3)Write a review
Potent in bone regeneration models. -
Suitable for cell culture. -
High yield in expression. -
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