Recombinant Human Interleukin 2 Receptor, Beta

• Cat.No.: IL2RB-1643H

Specification

• Cat. No.: IL2RB-1643H
• Description: Interleukin 2 receptor beta, also known as IL2RB, is a novel glycoprotein that has the ability to bind IL-2 alone and to associate with Tac antigen (IL-2R alpha) to form high-affinity IL-2 receptors. IL-2R beta is expressed on both circulating T lymphocytes and large granular lymphocytes. IL-2R beta mediates the initial phase of induction of lymphokine activated killer (LAK), natural killer (NK), and proliferative activities.
• Source: Sf 21 Insect Cells.
• State Of Matter: Lyophilized.
• Purity: >97% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Molecular Weight: The predicted molecular weight of Recombinant Human IL-2 sRβ is Mr 25 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 29-31 kDa.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Gene Information

• Gene Name: IL2RB interleukin 2 receptor, beta [ Homo sapiens ]
• Synonyms: IL2RB; interleukin 2 receptor, beta; CD122; P70-75; interleukin 2 receptor beta; CD122 antigen; high affinity IL-2 receptor beta subunit; OTTHUMP00000028799; IL-2 receptor
• Gene ID: 3560
• mRNA Refseq: NM_000878
• Protein Refseq: NP_000869
• MIM: 146710
• UniProt ID: P14784
• Chromosome Location: 22q13
• Pathway: Cytokine-cytokine receptor interaction; Endocytosis; Jak-STAT signaling pathway
• Function: interleukin-2 receptor activity; receptor activity