Recombinant Human IL2RB Protein, C-His-tagged
Cat.No. : | IL2RB-066H |
Product Overview : | Recombinant Human IL2RB Protein with C-His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Interleukin-2 (IL-2) is a T cell stimulatory cytokine best known for inducing T cell proliferation and NK cell proliferation and activation. IL-2 also promotes peripheral development of regulatory T cells (Tregs) . Conversely, IL-2 is involved in the activation-induced cell death (AICD) that is observed post T cell expansion by increasing levels of Fas on CD4+ T cells. The effects of IL-2 are mediated through a trimeric receptor complex consisting of IL-2Rα, IL-2Rβ, and the common gamma chain, γc. IL-2Rα binds exclusively to IL-2 with low affinity and increases the binding affinity of the whole receptor complex including IL-2Rβ and γc subunits. IL-15 also binds to IL-2Rβ. γc is used by other cytokines including IL-4, IL-7, IL-9, IL-15, and IL-21. Binding of IL-2 initiates signaling cascades involving Jak1, Jak3, Stat5, and the PI3K/Akt pathways. IL-2Rβ, also known as CD122, is a type I transmembrane protein that is expressed by natural killer cells and certain subsets of T cells in the periphery. IL-2Rβ surface expression is upregulated following antigen-induced activation. A heteromeric complex composed of IL-2Rβ and γc forms the intermediate affinity IL-2 receptor whereas a complex comprised of all three chains forms the high affinity receptor. Signaling through IL-2Rβ is mediated by Jak1, which phosphorylates numerous tyrosine residues in the cytoplasmic tail to promote the recruitment of the adaptor Shc to IL-2Rβ and enhance IL-2 receptor signaling. |
Source : | E. coli |
Species : | Human |
Tag : | C-His |
Molecular Mass : | ~24 kDa |
AA Sequence : | AVNGTSQFTCFYNSRANISCVWSQD GALQDTSCQVHAWPDRRRWNQTCEL LPVSQASWACNLILGAPDSQKLTTV DIVTLRVLCREGVRWRVMAIQDFKP FENLRLMAPISLQVVHVETHRCNIS WEISQASHYFERHLEFEARTLSPGH TWEEAPLLTLKQKQEWICLETLTPD TQYEFQVRVKPLQGEFTTWSPWSQP LAFRTKPAALGKDT |
Purity : | Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). |
Notes : | For research use only, not for use in diagnostic procedure. |
Storage : | Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. |
Concentration : | ≥0.5 mg/mL |
Storage Buffer : | PBS, 4M Urea, pH7.4 |
Gene Name : | IL2RB interleukin 2 receptor, beta [ Homo sapiens (human) ] |
Official Symbol : | IL2RB |
Synonyms : | IL2RB; interleukin 2 receptor, beta; IL15RB, interleukin 15 receptor, beta; interleukin-2 receptor subunit beta; CD122; p75; IL-2RB; CD122 antigen; IL-2R subunit beta; IL-2 receptor subunit beta; interleukin 15 receptor, beta; high affinity IL-2 receptor beta subunit; high affinity IL-2 receptor subunit beta; IL15RB; P70-75; |
Gene ID : | 3560 |
mRNA Refseq : | NM_000878 |
Protein Refseq : | NP_000869 |
MIM : | 146710 |
UniProt ID : | P14784 |
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IL2RB-2069R | Recombinant Rhesus Macaque IL2RB Protein, His (Fc)-Avi-tagged | +Inquiry |
IL2RB-453C | Recombinant Canine IL2RB Protein, His-tagged | +Inquiry |
IL2RB-5196H | Recombinant Human IL2RB Protein | +Inquiry |
◆ Lysates | ||
IL2RB-2906HCL | Recombinant Human IL2RB cell lysate | +Inquiry |
IL2RB-741CCL | Recombinant Canine IL2RB cell lysate | +Inquiry |
IL2RB-744MCL | Recombinant Mouse IL2RB cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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