Recombinant Human IL22 Protein, His-tagged
|Product Overview :||Biotinylated Recombinant Human Interleukin-22 is produced by Human 293 Cells. The target gene encoding A34-I179 is expressed with a 6His tag at the C terminus.|
- Gene Information
- Related Products
|Description :||Interleukin-22 (IL22) is a cytokine that belongs to the IL-10 family or IL-10 superfamily, a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 initiated its biological activity by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein IL-22BP. IL-22 can contribute to immune disease through the stimulation of inflammatory responses, S1s and defensins. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut.|
|Form :||Lyophilized frum a 0.2 um filtered solution of PBS, pH7.2.|
|Molecular Mass :||Predicted Molecular Weight: 20.8kDa
Apparent Molecular Weight: Biotinylated IL-22 protein appeared as a smear between 25-40kDa in a reducing SDS-PAGE gel due to glycosylation.
|AA Sequence :||A34-I179|
|Endotoxin :||Less than 0.1 EU/ug.|
|Storage :||Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7 centigrade for 2-7 days. Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months.
Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
|Reconstitution :||It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
|Quality Statement :||Purity: greater than 95% as determined by reducing SDS-PAGE|
|Shipping :||The product is shipped on dry ice pack.
Upon receipt, store it immediately at the temperature listed below.
|Gene Name :||IL22 interleukin 22 [ Homo sapiens (human) ]|
|Official Symbol :||IL22|
|Synonyms :||Interleukin-22; IL-22; Cytokine Zcyto18; IL-10-related T-cell-derived-inducible factor; IL22; ZCYTO18; TIFa; IL-21; IL-22; ILTIF; IL-TIF; IL-D110; zcyto18; TIFIL-23|
|Gene ID :||50616|
|mRNA Refseq :||NM_020525.5|
|Protein Refseq :||NP_065386.1|
|UniProt ID :||Q9GZX6|
|◆ Recombinant Protein|
|IL22-178I||Active Recombinant Human IL22 Protein||+Inquiry|
|IL22-002H||Active Recombinant Human IL22 Protein, His-tagged||+Inquiry|
|IL22-164M||Active Recombinant Mouse IL22 Protein||+Inquiry|
|Il22-178M||Recombinant Active Mouse IL22 Protein, His-tagged(C-ter)||+Inquiry|
|IL22-098I||Active Recombinant Human IL22 Protein (146 aa)||+Inquiry|
|IL22-5232HCL||Recombinant Human IL22 293 Cell Lysate||+Inquiry|
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
IL22 enhances gut epithelial repair mechanisms.
IL22 activates STAT3 to modulate downstream targets.
IL22 interacts synergistically with IL-17 during inflammation.
IL22 is involved in the pathogenesis of autoimmune diseases like Crohn's.
IL22 is implicated in metabolic syndrome by affecting insulin sensitivity.
IL22 expression is upregulated in psoriasis.
IL22 expression is upregulated during viral infections like Hepatitis C.
IL22 contributes to anti-tumor immunity by activating NK cells.
IL22 promotes Th22 cell differentiation.
IL22 polymorphisms affect its binding affinity and signaling.
Customer Reviews (3)Write a review
High specificity. -
Good for Th17 differentiation. -
Effective in gut repair assays. -
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