Recombinant Human Interleukin 4 Receptor
| Cat.No. : | IL4R-1238H |
| Product Overview : | Recombinant human IL4Ris a 23.7 kDa protein containing 207 amino acid residues consisting of onlythe extracellular domain of the IL4R. |
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- Gene Information
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| Cat. No. : | IL4R-1238H |
| Description : | HumanIL-4 exerts its biological effects via signaling through its receptor system,IL4R. There are two types of the IL4R complexes, the type I receptorconsisting of the IL4R alpha and the common gamma chain, yc and the type IIreceptor consisting of IL4R and the IL-13R alpha. The IL4R chain contains anextracellular domain of 207 amino acids, a transmembrane domain of 24 aminoacids, and an intracellular domain of 569 amino acids. |
| Source : | A293 cells |
| Species : | Human |
| Form : | Lyophilized |
| Purity : | Greater than 97% bySDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per ug(1EU/ug). |
| Biological Activity : | The ED50was determined by its ability to inhibit the IL-4 dependent proliferation ofhuman TF-1 cells is < 5.0 ng/ml (in the presence of 0.5 ng/ml of IL-4),corresponding to a specific activity of > 2 x 105 units/mg. |
| Reconstitution : | Werecommend a quick spin followed by reconstitution in water to a concentrationof 0.1-1.0 mg/ml. This solution can then be diluted into other aqueousbuffers and stored at 40°C for 1 week or -200°C forfuture use. |
| storage : | Thelyophilized protein is stable for a few weeks at room temperature, but beststored at -200°C. Reconstituted IL4R alpha should be storedin working aliquots at -200°C. |
| OfficialSymbol : | IL4R |
| Gene Name : | IL4R interleukin 4 receptor [ Homosapiens ] |
| Synonyms : | IL4R; interleukin 4 receptor;CD124; IL4RA; OTTHUMP00000122506; interleukin 4 receptor alpha chain;interleukin-4 receptor alpha chain; IL-4R-alpha; CD124 antigen |
| Gene ID : | 3566 |
| mRNA Refseq : | NM_000418 |
| Protein Refseq : | NP_000409 |
| MIM : | 147781 |
| UniProt ID : | P24394 |
| Chromosome Location : | 16p12.1-p11.2 |
| Pathway : | Cytokine-cytokine receptorinteraction; Jak-STAT signaling pathway; Hematopoietic cell lineage |
| Function : | interleukin-4 receptoractivity; receptor activity; protein binding; receptor signaling proteinactivity |
Products Types
| ◆ Recombinant Protein | ||
| IL4R-177I | Active Recombinant Human IL4R Protein | +Inquiry |
| IL4R-2437P | Recombinant Pig IL4R Protein (33-240 aa), His-sumostar-tagged | +Inquiry |
| IL4R-331H | Recombinant Human IL4R Protein, His-tagged | +Inquiry |
| IL4R-330C | Recombinant Cynomolgus monkey IL4R Protein, Fc-tagged | +Inquiry |
| IL4R-2388P | Recombinant Pig IL4R Protein (33-240 aa), His-tagged | +Inquiry |
| ◆ Lysates | ||
| IL4R-2719HCL | Recombinant Human IL4R cell lysate | +Inquiry |
| IL4R-1051RCL | Recombinant Rat IL4R cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionIL4R is a synthetic protein that mimics the IL-4 signaling pathway in nature and binds to the IL-4 receptor in cells, which can be used to study the IL-4 signaling pathway and related diseases.
Common IL4R production technologies include prokaryotic expression systems and mammalian cell expression systems.
This protein is used in tumor immunotherapy, which can promote anti-tumor immune response and enhance the anti-tumor effect of cytotoxic T lymphocytes.
It is mainly used in immunology, drug research and other fields. It is also widely used in vaccines, biotechnology, cancer treatment and so on.
IL4R is used to treat severe pheochromocytome-induced aerodoritis and was approved by the FDA as the first drug to treat this disease.
IL4R cannot generally be administered orally, and needs to be administered by injection or intravenous drip.
Customer Reviews (3)
Write a reviewEasy to attach to the surface of cells or materials. -
It has growth factor activity to promote cell growth and proliferation. -
In animals or humans caused by the prone production of antibodies. -
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