Recombinant Human IL4R Protein, C-His-tagged

• Cat.No.: IL4R-068H
• Product Overview: Recombinant Human IL4R Protein with C-His tag was expressed in E. coli.

Specification

• Description: The IL-2 receptor is a multicomponent complex consisting of three subunits, α, β and γ, each of which is required for high affinity binding of IL-2. The α chain functions primarily in binding IL-2, whereas the β and γ chains contribute to IL-2 binding and are essential to IL-2-induced activation of signaling pathways leading to T cell growth. Both IL-4R and IL-7R were initially described as single chain, high-affinity ligand-binding cytokine receptors. However, it is now well established that the IL-2Rγ chain functions as a second subunit of the high affinity IL-4R and IL-7R receptors. Consequently, the originally described subunits of these latter receptors are now referred to as IL-4Rα and IL-7Rα, respectively, while the common subunit is referred to as γc. Although the common γ chain enhances ligand binding in these three cytokine receptors, it has no capacity to bind these ligands on its own. There is evidence that the γc chain is also a subunit of IL-13R.
• Source: E. coli
• Species: Human
• Tag: C-His
• Molecular Mass: ~23 kDa
• AA Sequence: KVLQEPTCVSDYMSISTCEWKMNGP TNCSTELRLLYQLVFLLSEAHTCIP ENNGGAGCVCHLLMDDVVSADNYTL DLWAGQQLLWKGSFKPSEHVKPRAP GNLTVHTNVSDTLLLTWSNPYPPDN YLYNHLTYAVNIWSENDPADFRIYN VTYLEPSLRIAASTLKSGISYRARV RAWAQCYNTTWSEWSPSTKWHNSYR EPFEQH
• Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).
• Notes: For research use only, not for use in diagnostic procedure.
• Storage: Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles.
• Concentration: ≥0.5 mg/mL
• Storage Buffer: PBS, 4M Urea, pH7.4

Gene Information

• Gene Name: IL4R interleukin 4 receptor [ Homo sapiens (human) ]
• Official Symbol: IL4R
• Synonyms: IL4R; interleukin 4 receptor; interleukin-4 receptor subunit alpha; CD124; IL-4 receptor subunit alpha; interleukin-4 receptor alpha chain; IL4RA; IL-4RA
• Gene ID: 3566
• mRNA Refseq: NM_000418
• Protein Refseq: NP_000409
• MIM: 147781
• UniProt ID: P24394