Recombinant Human IRAK4 Protein, MYC/DDK-tagged, C13 and N15-labeled

• Cat.No.: IRAK4-058H
• Product Overview: IRAK4 MS Standard C13 and N15-labeled recombinant protein (NP_057207) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 51.5 kDa
• AA Sequence: MNKPITPSTYVRCLNVGLIRKLSDF IDPQEGWKKLAVAIKKPSGDDRYNQ FHIRRFEALLQTGKSPTSELLFDWG TTNCTVGDLVDLLIQNEFFAPASLL LPDAVPKTANTLPSKEAITVQQKQM PFCDKDRTLMTPVQNLEQSYMPPDS SSPENKSLEVSDTRFHSFSFYELKN VTNNFDERPISVGGNKMGEGGFGVV YKGYVNNTTVAVKKLAAMVDITTEE LKQQFDQEIKVMAKCQHENLVELLG FSSDGDDLCLVYVYMPNGSLLDRLS CLDGTPPLSWHMRCKIAQGAANGIN FLHENHHIHRDIKSANILLDEAFTA KISDFGLARASEKFAQTVMTSRIVG TTAYMAPEALRGEITPKSDIYSFGV VLLEIITGLPAVDEHREPQLLLDIK EEIEDEEKTIEDYIDKKMNDADSTS VEAMYSVASQCLHEKKNKRPDIKKV QQLLQEMTASTRTRPLEQKLISEED LAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: IRAK4 interleukin 1 receptor associated kinase 4 [ Homo sapiens (human) ]
• Official Symbol: IRAK4
• Synonyms: IRAK4; interleukin 1 receptor associated kinase 4; IPD1; IRAK-4; NY-REN-64; REN64; interleukin-1 receptor-associated kinase 4; renal carcinoma antigen NY-REN-64; EC 2.7.11.1
• Gene ID: 51135
• mRNA Refseq: NM_016123
• Protein Refseq: NP_057207
• MIM: 606883
• UniProt ID: Q9NWZ3